Mentoring translational scientists in international infectious disease research

指导国际传染病研究中的转化科学家

基本信息

批准号：
10320014
负责人：
Bryan R Greenhouse
金额：
$ 19.16万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-01-22 至 2023-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10320014
关键词：
Adult African Antibodies Antibody Response Antigenic Diversity Antigenic Variation Antigens Area Award Bacteriophages Bioinformatics Biological Assay Biological Specimen Banks Biometry Career Choice Caring Child Clinic Clinical Clinical Data Communicable Diseases Complex Culicidae Data Data Analyses Development Disease Environment Epidemiology Evaluation Exposure to Focal Infection Funding Genetic Research Genetic Variation Genotype Geography Goals Human Immune Immunity Individual Infection Infectious Disease Epidemiology Infectious Diseases Research Infrastructure Internal Medicine International Intervention Kinetics Laboratories Learning Link Malaria Measures Mediating Medical Mentors Mentorship Methods Mid-Career Clinical Scientist Award (K24)Midcareer Investigator Award in Patient-Oriented Research Molecular Computations Outcome Parasites Participant Patients Physicians Plasmodium falciparum Play Population Genetics Positioning Attribute Proteome Publications Questionnaires Research Research Personnel Research Support Resource-limited setting Risk Factors Role Sampling Scientist Serology test Shapes Specimen Structure Talents Techniques Technology Time Training Translational Research Travel Uganda United States National Institutes of Health Vaccines Variant Visit Work acquired immunity base burden of illness career development cohort cost experience field study genetic epidemiology genetic makeup global health improved interest international center malaria transmission next generation novel novel strategies patient oriented research programs recruit research study response skills success translational scientist transmission process

项目摘要

Abstract Dr. Greenhouse is a physician scientist trained in internal medicine, infectious diseases, and biostatistics. His research goals are to advance the understanding of malaria epidemiology, in particular transmission dynamics and host immunity. To study the complex interplay between malaria parasites, human and mosquito hosts, and the environment, Dr. Greenhouse's work combines field, laboratory, and advanced data analysis techniques, including development of novel technological and analytical approaches. There is a large and growing interest in translational global health research among trainees, particularly clinicians. However, success in this field requires obtaining a broad skill set and lacks an established training path or the sufficient availability of appropriate mentors. Dr. Greenhouse has been highly productive in this area of patient oriented research (POR), as evidenced by his publication record and portfolio of funded research. He is dedicated to mentoring the next generation of scientists, but lacks dedicated time for mentoring or career development. In this application, Dr. Greenhouse outlines his qualifications in performing high quality POR and track record in mentoring successful trainees. He presents a plan for improving the quality and quantity of his mentoring, including formal training in mentorship, developing a structured mentorship plan, and recruiting talented trainees from a large pool of candidates, including infectious diseases fellows and clinicians from resource limited settings. He will also use protected time to build advanced skills in sequencing, bioinformatics, and population genetics. Dr. Greenhouse ultimately plans to develop a center of excellence (with the support of his division) in molecular and computational infectious disease epidemiology in order to advance interdisciplinary training and accelerate research in this area. Dr. Greenhouse's existing research portfolio provides a wealth of opportunities for trainees in 3 related areas of translational malaria research: genetic epidemiology to track malaria transmission and geographical spread, novel serologic assays of P. falciparum exposure for improved surveillance in control and elimination, and the epidemiology of P. falciparum infection and immunity. In addition, Dr. Greenhouse proposes to augment his POR with 3 novel aims to be supported by this K24 award, leveraging the highly successful East African International Center of Excellence in Malaria Research (ICEMR) study, funded by the NIH for another 6 years: 1) to develop sequencing-based platforms for comprehensive characterization of P. falciparum antigenic variation and the host antibody response; 2) to determine how antibody responses develop in response to natural P. falciparum infection, and how pre-existing and evolving responses are associated with clinical outcomes of these infections; and 3) to determine whether P. falciparum infections acquired during travel are different in terms of genetic makeup and clinical outcomes than locally acquired infections. These aims will support his career development and mentoring objectives, and generate preliminary data for new lines of POR.

抽象的 Greenhouse博士是一位受过内科，传染病和的医师科学家生物统计学。他的研究目标是提高对疟疾流行病学的理解，特别是传输动力学和宿主免疫。研究疟疾寄生虫之间的复杂相互作用，人类以及蚊子主持人，以及环境，Greenhouse博士的工作结合了田野，实验室和高级数据分析技术，包括开发新型技术和分析方法。有一个对学员，特别是临床医生之间的转化全球健康研究的兴趣越来越大。但是，该领域的成功需要获得广泛的技能，并且缺乏既定的培训路径或足够的适当导师的可用性。 Greenhouse博士在这一患者领域的生产力很高定向研究（POR），他的出版记录和资助研究的投资组合证明了这一点。他是致力于指导下一代科学家，但缺乏专门的指导时间或职业的时间发展。在此应用程序中，温室博士概述了他在执行高质量POR和指导成功的学员的记录。他提出了提高他的质量和数量的计划指导，包括指导的正式培训，制定结构化指导计划和招聘来自大量候选人的才华横溢的学员，包括传染病研究员和临床医生资源有限的设置。他还将利用受保护的时间来建立测序，生物信息学的高级技能，和人口遗传学。 Greenhouse博士最终计划建立一个卓越中心（在他在分子和计算传染病流行病学方面的分裂）跨学科的培训和加速该领域的研究。 Greenhouse博士现有的研究组合为受训者提供了大量相关学员的机会转化疟疾研究领域：追踪疟疾传播和地理的遗传流行病学扩散，新型的恶性疟原虫暴露的血清学测定，以改善控制和消除的监视，恶性疟原虫感染和免疫力的流行病学。此外，Greenhouse博士建议增强了他的POR 3小说的目标，以获得这个K24奖的支持，利用了非常成功的东方非洲国际疟疾研究卓越中心（ICEMR）研究，由NIH资助另外6 年：1）开发基于测序的平台，以全面表征恶性疟原虫抗原变异和宿主抗体反应； 2）确定抗体反应如何响应天然恶性疟原虫感染，以及临床的预先存在和不断发展的反应如何这些感染的结果； 3）确定旅行期间获得的恶性疟原虫感染是否是在遗传组成和临床结果方面，不同于本地获得的感染。这些目标会支持他的职业发展和指导目标，并为新产品线生成初步数据。