Mentoring translational scientists in international infectious disease research

指导国际传染病研究中的转化科学家

• 批准号: 10534671
• 负责人: Bryan R Greenhouse
• 金额: $ 19.16万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-01-22 至 2023-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10534671
• 关键词: Acceleration; Adult; African; Antibodies; Antibody Response; Antigenic Diversity; Antigenic Variation; Antigens; Area; Award; Bacteriophages; Bioinformatics; Biological Assay; Biological Specimen Banks; Biometry; Career Choice; Caring; Child; Clinic; Clinical; Clinical Data; Communicable Diseases; Communication; Complex; Culicidae; Data; Data Analyses; Dedications; Development; Disease; Environment; Epidemiology; Evaluation; Exposure to; Focal Infection; Funding; Genetic Variation; Genotype; Geography; Goals; Human; Immune; Immunity; Individual; Infection; Infectious Disease Epidemiology; Infectious Diseases Research; Infrastructure; Internal Medicine; International; Intervention; Kinetics; Laboratories; Learning; Link; Malaria; Measures; Mediating; Medical; Mentors; Mentorship; Methods; Mid-Career Clinical Scientist Award (K24); Midcareer Investigator Award in Patient-Oriented Research; Molecular; Outcome; Parasites; Participant; Patients; Physicians; Plasmodium falciparum; Play; Population Genetics; Positioning Attribute; Productivity; Proteome; Publications; Qualifying; Questionnaires; Research; Research Personnel; Research Support; Resource-limited setting; Risk Factors; Role; Sampling; Scientist; Serology test; Shapes; Specimen; Structure; Talents; Techniques; Technology; Time; Training; Translational Research; Travel; Uganda; United States National Institutes of Health; Vaccines; Variant; Visit; Work; acquired immunity; burden of illness; career; career development; cohort; cost; experience; field study; genetic epidemiology; genetic makeup; global health; improved; interest; international center; malaria transmission; new technology; next generation; novel; novel strategies; patient oriented research; programs; recruit; research study; response; skills; success; translational scientist; transmission process

Abstract Dr. Greenhouse is a physician scientist trained in internal medicine, infectious diseases, and biostatistics. His research goals are to advance the understanding of malaria epidemiology, in particular transmission dynamics and host immunity. To study the complex interplay between malaria parasites, human and mosquito hosts, and the environment, Dr. Greenhouse's work combines field, laboratory, and advanced data analysis techniques, including development of novel technological and analytical approaches. There is a large and growing interest in translational global health research among trainees, particularly clinicians. However, success in this field requires obtaining a broad skill set and lacks an established training path or the sufficient availability of appropriate mentors. Dr. Greenhouse has been highly productive in this area of patient oriented research (POR), as evidenced by his publication record and portfolio of funded research. He is dedicated to mentoring the next generation of scientists, but lacks dedicated time for mentoring or career development. In this application, Dr. Greenhouse outlines his qualifications in performing high quality POR and track record in mentoring successful trainees. He presents a plan for improving the quality and quantity of his mentoring, including formal training in mentorship, developing a structured mentorship plan, and recruiting talented trainees from a large pool of candidates, including infectious diseases fellows and clinicians from resource limited settings. He will also use protected time to build advanced skills in sequencing, bioinformatics, and population genetics. Dr. Greenhouse ultimately plans to develop a center of excellence (with the support of his division) in molecular and computational infectious disease epidemiology in order to advance interdisciplinary training and accelerate research in this area. Dr. Greenhouse's existing research portfolio provides a wealth of opportunities for trainees in 3 related areas of translational malaria research: genetic epidemiology to track malaria transmission and geographical spread, novel serologic assays of P. falciparum exposure for improved surveillance in control and elimination, and the epidemiology of P. falciparum infection and immunity. In addition, Dr. Greenhouse proposes to augment his POR with 3 novel aims to be supported by this K24 award, leveraging the highly successful East African International Center of Excellence in Malaria Research (ICEMR) study, funded by the NIH for another 6 years: 1) to develop sequencing-based platforms for comprehensive characterization of P. falciparum antigenic variation and the host antibody response; 2) to determine how antibody responses develop in response to natural P. falciparum infection, and how pre-existing and evolving responses are associated with clinical outcomes of these infections; and 3) to determine whether P. falciparum infections acquired during travel are different in terms of genetic makeup and clinical outcomes than locally acquired infections. These aims will support his career development and mentoring objectives, and generate preliminary data for new lines of POR.

抽象的 Greenhouse 博士是一位接受过内科、传染病和其他领域培训的医师科学家 生物统计学。他的研究目标是增进对疟疾流行病学的理解，特别是 传播动力学和宿主免疫力。研究疟疾寄生虫、人类之间复杂的相互作用 和蚊子宿主以及环境，Gre​​enhouse 博士的工作结合了现场、实验室和先进的技术 数据分析技术，包括开发新颖的技术和分析方法。有一个 受训者，尤其是临床医生，对全球健康转化研究产生了浓厚的兴趣，而且兴趣日益浓厚。 然而，该领域的成功需要获得广泛的技能，并且缺乏既定的培训路径或 足够的合适导师。 Greenhouse 博士在这一领域的患者方面卓有成效 定向研究（POR），他的发表记录和资助研究组合证明了这一点。他是 致力于指导下一代科学家，但缺乏专门的指导或职业时间 发展。在此申请中，Greenhouse 博士概述了他执行高质量 POR 和 指导成功学员的记录。他提出了一个提高其质量和数量的计划。 指导，包括正式的指导培训、制定结构化的指导计划以及招聘 来自大量候选人的才华横溢的学员，包括来自以下国家的传染病研究员和临床医生 资源有限的设置。他还将利用受保护的时间来培养测序、生物信息学、 和群体遗传学。格林豪斯博士最终计划建立一个卓越中心（在 他的部门）在分子和计算传染病流行病学领域，以推进 跨学科培训并加速该领域的研究。 Greenhouse 博士现有的研究成果为 3 个相关领域的学员提供了丰富的机会 转化疟疾研究领域：追踪疟疾传播的遗传流行病学和地理 传播，恶性疟原虫暴露的新型血清学测定，以改进控制和消除监测， 以及恶性疟原虫感染和免疫的流行病学。此外，格林豪斯博士建议 通过 3 部小说来扩大他的 POR，旨在获得 K24 奖项的支持，利用非常成功的东方 非洲国际疟疾研究卓越中心 (ICEMR) 研究由 NIH 资助另外 6 年：1) 开发基于测序的平台，以全面表征恶性疟原虫抗原 变异和宿主抗体反应； 2) 确定抗体反应如何发展以响应 自然恶性疟原虫感染，以及先前存在和不断发展的反应如何与临床相关 这些感染的结果； 3) 确定旅行期间获得的恶性疟原虫感染是否是 在基因组成和临床结果方面与局部获得性感染不同。这些目标将 支持他的职业发展和指导目标，并为新的 POR 线生成初步数据。