Mentoring translational scientists in international infectious disease research

指导国际传染病研究中的转化科学家

• 批准号: 10534671
• 负责人: Bryan R Greenhouse
• 金额: $ 19.16万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-01-22 至 2023-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10534671
• 关键词: Acceleration; Adult; African; Antibodies; Antibody Response; Antigenic Diversity; Antigenic Variation; Antigens; Area; Award; Bacteriophages; Bioinformatics; Biological Assay; Biological Specimen Banks; Biometry; Career Choice; Caring; Child; Clinic; Clinical; Clinical Data; Communicable Diseases; Communication; Complex; Culicidae; Data; Data Analyses; Dedications; Development; Disease; Environment; Epidemiology; Evaluation; Exposure to; Focal Infection; Funding; Genetic Variation; Genotype; Geography; Goals; Human; Immune; Immunity; Individual; Infection; Infectious Disease Epidemiology; Infectious Diseases Research; Infrastructure; Internal Medicine; International; Intervention; Kinetics; Laboratories; Learning; Link; Malaria; Measures; Mediating; Medical; Mentors; Mentorship; Methods; Mid-Career Clinical Scientist Award (K24); Midcareer Investigator Award in Patient-Oriented Research; Molecular; Outcome; Parasites; Participant; Patients; Physicians; Plasmodium falciparum; Play; Population Genetics; Positioning Attribute; Productivity; Proteome; Publications; Qualifying; Questionnaires; Research; Research Personnel; Research Support; Resource-limited setting; Risk Factors; Role; Sampling; Scientist; Serology test; Shapes; Specimen; Structure; Talents; Techniques; Technology; Time; Training; Translational Research; Travel; Uganda; United States National Institutes of Health; Vaccines; Variant; Visit; Work; acquired immunity; burden of illness; career; career development; cohort; cost; experience; field study; genetic epidemiology; genetic makeup; global health; improved; interest; international center; malaria transmission; new technology; next generation; novel; novel strategies; patient oriented research; programs; recruit; research study; response; skills; success; translational scientist; transmission process

Abstract Dr. Greenhouse is a physician scientist trained in internal medicine, infectious diseases, and biostatistics. His research goals are to advance the understanding of malaria epidemiology, in particular transmission dynamics and host immunity. To study the complex interplay between malaria parasites, human and mosquito hosts, and the environment, Dr. Greenhouse's work combines field, laboratory, and advanced data analysis techniques, including development of novel technological and analytical approaches. There is a large and growing interest in translational global health research among trainees, particularly clinicians. However, success in this field requires obtaining a broad skill set and lacks an established training path or the sufficient availability of appropriate mentors. Dr. Greenhouse has been highly productive in this area of patient oriented research (POR), as evidenced by his publication record and portfolio of funded research. He is dedicated to mentoring the next generation of scientists, but lacks dedicated time for mentoring or career development. In this application, Dr. Greenhouse outlines his qualifications in performing high quality POR and track record in mentoring successful trainees. He presents a plan for improving the quality and quantity of his mentoring, including formal training in mentorship, developing a structured mentorship plan, and recruiting talented trainees from a large pool of candidates, including infectious diseases fellows and clinicians from resource limited settings. He will also use protected time to build advanced skills in sequencing, bioinformatics, and population genetics. Dr. Greenhouse ultimately plans to develop a center of excellence (with the support of his division) in molecular and computational infectious disease epidemiology in order to advance interdisciplinary training and accelerate research in this area. Dr. Greenhouse's existing research portfolio provides a wealth of opportunities for trainees in 3 related areas of translational malaria research: genetic epidemiology to track malaria transmission and geographical spread, novel serologic assays of P. falciparum exposure for improved surveillance in control and elimination, and the epidemiology of P. falciparum infection and immunity. In addition, Dr. Greenhouse proposes to augment his POR with 3 novel aims to be supported by this K24 award, leveraging the highly successful East African International Center of Excellence in Malaria Research (ICEMR) study, funded by the NIH for another 6 years: 1) to develop sequencing-based platforms for comprehensive characterization of P. falciparum antigenic variation and the host antibody response; 2) to determine how antibody responses develop in response to natural P. falciparum infection, and how pre-existing and evolving responses are associated with clinical outcomes of these infections; and 3) to determine whether P. falciparum infections acquired during travel are different in terms of genetic makeup and clinical outcomes than locally acquired infections. These aims will support his career development and mentoring objectives, and generate preliminary data for new lines of POR.

摘要 格林博士是一名内科科学家，受过内科、传染病和 生物统计学。他的研究目标是促进对疟疾流行病学的了解，特别是 传播动力学和宿主免疫力。为了研究疟疾寄生虫之间复杂的相互作用，人类 和蚊子宿主，以及环境，格林博士的工作结合了野外、实验室和高级 数据分析技术，包括开发新的技术和分析方法。有一个 学员，尤其是临床医生对翻译型全球卫生研究的兴趣日益浓厚。 然而，在这一领域的成功需要获得广泛的技能集，并且缺乏既定的培训途径或 有足够的合适的导师。格林医生在这一领域的患者中一直很有成效 定向研究(POR)，他的出版记录和资助研究组合证明了这一点。他是 致力于指导下一代科学家，但缺乏专门的时间指导或职业生涯 发展。在这份申请中，格罗姆博士概述了他在执行高质量POR和 在指导成功的学员方面有良好的记录。他提出了一个计划，以提高他的产品的质量和数量 辅导，包括正规的辅导培训，制定结构化的辅导计划，以及招聘 来自大量候选人的有才华的实习生，包括传染病研究员和来自 资源受限设置。他还将利用受保护的时间建立测序、生物信息学、 和种群遗传学。格林博士最终计划发展一个卓越的中心(在 他的部门)在分子和计算传染病流行病学方面取得进展 开展跨学科培训，加快这一领域的研究。 格雷厄姆博士现有的研究组合为学员提供了丰富的机会，涉及3个相关领域 疟疾翻译研究领域：追踪疟疾传播和地理分布的遗传流行病学 传播的，新的恶性疟原虫暴露的血清学分析，以改进控制和消除的监测， 恶性疟原虫感染和免疫的流行病学。此外，格林博士还建议 用3部小说来增强他的POR，以获得这个K24奖的支持，利用非常成功的东部 非洲国际疟疾研究英才中心(ICEMR)研究，由美国国立卫生研究院资助 年：1)开发基于测序的恶性疟原虫抗原综合鉴定平台 变异和宿主抗体反应；2)确定抗体反应是如何发展的 自然恶性疟原虫感染，以及先前存在的和不断演变的反应如何与临床相关 这些感染的结果；以及3)确定在旅行期间获得的恶性疟原虫感染是否 在基因构成和临床结果方面不同于当地获得的感染。这些目标将 支持他的职业发展和指导目标，并为新的POR系列生成初步数据。