AI Design for Personalised Digital Therapy for early dementia

痴呆症是一个日益严重的问题，因为人们受益于更长的寿命，但随着年龄的增长失去认知感觉和身体协调。由于药物只能缓解症状，医疗保健系统和家庭支持网络的负担迅速增加。目前全球有4700万人患有痴呆症，到2030年，这一数字将达到7500万。每3秒钟就有一名患者患上痴呆症，地球仪每年有1000万新病例。早期干预市场目前为8180亿美元，预计到2030年将上升至2万亿美元，因为目前没有任何类型的痴呆症的治愈方法，这是一个尚未开发的市场，因为该行业专注于痴呆症的诊断和药物输送。目前的痴呆症治疗包括仅使用抗痴呆症药物治疗阿尔茨海默病，并且患有早期痴呆症（包括临床前痴呆症和轻度认知障碍（MCI））的人的治疗需求仍然高度未得到满足。由于没有特别针对痴呆症的治疗，因此对症状前和早期痴呆症患者的认知改善系统的需求尚未得到满足。所提出的神经反馈系统是一种自我管理解决方案，但也是一种治疗系统，其为所玩的每个游戏提供认知地图响应，包括（1）认知评分和（2）大脑轮廓响应。认知图可帮助使用者、照顾者和临床医生了解病人的认知能力增强情况，以及大脑目前适应和预防痴呆症症状的能力，作为辅助工具。这项技术的好处是：（1）非侵入性;（2）提高痴呆症患者的心理能力;（3）可以提供早期痴呆症治疗;（4）确保病人更长时间的独立性;（5）确保病人的健康。（5）减少对NHS的依赖，改善英国经济;（6）将加强英国作为痴呆症研究领导者的地位。

Dementia is an increasing problem as people benefit from longer lifespans but lose cognitive senses and physical coordination with age. With medication only able to alleviate symptoms, the burden on the healthcare system and family support networks has grown rapidly.There are presently 47m people worldwide living with dementia and by 2030 this number will be 75m. Every 3 seconds, a patient develops dementia, and there are 10 million new cases every year around the globe. The early intervention market is currently $818bn which is expected to rise to $2 trillion by 2030, because there is no cure of any types of dementia currently and it is an untapped market since the industry focuses on diagnosis & drug delivery for dementia.The current treatment of dementia comprises the use of anti-dementia drugs for Alzheimer's disease only, and the therapeutic needs of people with early dementia including preclinical dementia and mild cognitive impairment (MCI) remain highly unmet. The need for a cognitive improvement system for pre-symptoms & early dementia patients is unmet since no treatment is available especially for dementia.The proposed neurofeedback system is a self-management solution but also a therapeutic system that provides a cognitive map response for each game played which includes (1) cognitive scores and (2) brain profile responses. The cognitive map produced will help the user, carer and the clinician to understand the patients' cognitive enhancement and the brains' current capacity to adapt and prevent the dementia symptoms as a secondary tool.The benefits of the technology are: (1) non-invasive; (2) improved mental ability for dementia patients; (3) can provide early dementia treatment; (4) ensures patient's longer independence; (5) reduced reliance upon NHS and improves UK economy; and (6) will strengthen the UK as a leader in dementia research.