Bioinformatics

生物信息学

• 批准号: 10319512
• 负责人: Nicholas D Socci
• 金额: $ 89.16万
• 依托单位: SLOAN-KETTERING INST CAN RESEARCH
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-01-20 至 2023-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10319512
• 关键词: Bioinformatics; Biological Assay; Cancer Center Support Grant; Clinic; Code; Collaborations; Collection; Communities; Computer software; Computing Methodologies; Custom; Data; Data Analyses; Databases; Educational workshop; Ensure; Evaluation; Goals; High Performance Computing; Infrastructure; Institution; Laboratories; Maintenance; Methods; Mission; Play; Process; Publishing; Quality Control; Reproducibility; Research; Research Personnel; Role; Savings; Services; System; Time; Training; Walking; Work; algorithm development; base; cBioPortal; cost effective; cost effectiveness; data access; experimental study; repository; research and development; tool

ABSTRACT The primary function of the Bioinformatics Core is to provide bioinformatics services and infrastructure for the MSK research community. This can range from providing complete analysis services beginning with raw data and ending with publishable results or it can consist of assisting and supporting the growing number of computational researchers with specific data analyses. A central mission is the creation and maintenance of both a repository of robust, vetted software applications and pipelines that implement the current state-of-the- art data analysis and a collection of well documented methods and best-practices. This ensures that critical analysis steps are done in a reliable, reproducible, and understandable way, freeing the laboratory-based staff to focus on the analysis that is specific to their particular experiment and saving them time and effort in re- inventing well known bioinformatics processes. This also leads to a far more cost-effective process with greater quality control. This consistency enables the institution to provide sharable and consistent results that can be further used for integrative and pan-group analysis. The Core also plays a central role in training staff in both methods and in the use of the institution’s high performance computing infrastructure. Additionally, the Bioinformatics Core provides customized computational and statistical assistance, facilities collaboration and integrative analysis via data and code sharing, enables access to institutional databases and provides applications for the creation and curation of research data. The Core trains computational and bioinformatics staff working in concert with other departments to develop and teach workshops and training seminars. Finally, the Core works on the research and development of algorithmic best practices, evaluates current applications and pipelines, and deploys new tools as new experimental methods and assays are developed.

抽象的 生物信息学核心的主要功能是提供生物信息学服务和基础架构 MSK研究社区。这可以从提供原始数据开始的完整分析服务范围 并以可发布的结果结尾，或者可以包括协助和支持日益增长的数量 具有特定数据分析的计算研究人员。中心任务是创建和维护 既有坚固，审查的软件应用程序和管道的存储库，都可以实现当前的最新最新 艺术数据分析以及有记录良好的方法和最佳实践的集合。这确保了关键 分析步骤是以可靠，可重复和可理解的方式完成的，可以释放基于实验室的员工 专注于特定于其特定实验的分析，并节省他们的时间和精力 发明众所周知的生物信息学过程。这也导致一个更具成本效益的过程，并且更大 质量控制。这种一致使机构能够提供可共享和一致的结果 进一步用于综合和泛组分析。核心在培训人员中也起着核心作用 方法和使用机构的高性能计算基础架构。 此外，生物信息学核心提供定制的计算和统计帮助，设施 通过数据和代码共享协作和集成分析，可以访问机构数据库和 为创建和策划研究数据提供了应用。核心训练计算和 生物信息学人员与其他部门共同开发和教授讲习班和培训 污水。最后，核心致力于研究算法最佳实践的研究和开发，评估 当前的应用程序和管道，并以新的实验方法和测定为部署新工具 发达。