HIGH FIELD MRI AND THE LABYRINTH: VESTIBULAR STIMULATION AND NEW IMAGING TECHNIQUES

高场 MRI 和迷路：前庭刺激和新成像技术

• 批准号: 10321281
• 负责人: Bryan Kevin Ward
• 金额: $ 19.9万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-01-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10321281
• 关键词: Address; Anatomy; Animals; Asphyxia; Aspiration Pneumonia; Atelectasis; Award; Biomedical Engineering; Chinchilla (genus); Clinical; Conscious; Curiosities; Data; Development; Diagnosis; Disease; Dizziness; Edema; Endolymph; Environment; Ethics; Functional disorder; Funding; Future; Goals; Grant; Hair Cells; Head; Head and Neck Surgery; Head and neck structure; Health; Human; Image; Imaging Techniques; Interdisciplinary Study; K-Series Research Career Programs; Knowledge; Labyrinth; Lead; Liquid substance; MRI Scans; Magnetic Resonance Imaging; Magnetism; Mammals; Meniere' s Disease; Mentors; Methods; Movement; Nausea; Nausea and Vomiting; Neurology; Noise; North America; Otolaryngology; Otology; Participant; Pathologic Nystagmus; Pathology; Patients; Pattern; Performance; Phase; Physics; Physiological; Positional Vertigo; Positioning Attribute; Problem Solving; Prospective Studies; Protocols documentation; Publishing; Radiology Specialty; Research; Research Personnel; Resolution; Safety; Scanning; Signal Transduction; Structure; Supination; Surface; System; Target Populations; Techniques; Technology; Testing; Time; Training; Universities; Vertigo; Vestibular Labyrinth; Vestibule; Work; anatomic imaging; career; cellular transduction; clinical practice; cost; cost effective; experience; fluid flow; high resolution imaging; human imaging; imaging modality; improved; in vivo; inner ear diseases; magnetic field; medical schools; membranous labyrinth; nervous system disorder; novel; professor; programs; recruit; responsible research conduct; risk minimization; skills; temporal measurement; vector; ward

ABSTRACT Dr. Bryan Ward is an assistant professor in the department of Otolaryngology-Head & Neck Surgery at the Johns Hopkins School of Medicine, where he is dedicating his clinical practice to vestibular disorders, otology and neurotology. He is seeking a mentored career development award in order to fill knowledge gaps in imaging of the inner ear using MRI. His long-term goal is establishing an independent research program that is devoted to using imaging to improve the diagnosis and treatment of patients with dizziness and imbalance. The candidate proposes expanding on his prior work studying the physiologic effects of strong magnetic fields on the inner ear vestibular system to imaging the fluid flow in the labyrinth of healthy chinchillas and humans. The training plan immerses Dr. Ward in the multidisciplinary research and clinical environments in the departments of radiology, neurology, biomedical engineering and otolaryngology at the Johns Hopkins University School of Medicine. Specific training goals include: (1) receive training in the physics of MRI and how images are acquired, (2) complete training in MRI safety and performing prospective studies using imaging modalities, (3) pursue additional training in the ethical and responsible conduct of research, and (4) integrate his clinical training in vestibular disorders with this knowledge as he develops into an independent investigator. High magnetic field MRIs can increase spatial and temporal resolution of images as a result of increased signal-to-noise ratio; however, these MRI machines also cause dizziness and vertigo in humans. We previously showed that all healthy humans have nystagmus in an MRI and hypothesized that this is due to a Lorentz force occurring in the labyrinth. The specific aims of the proposed research are to: (1) test the hypothesis that a Lorentz force causes fluid flow that can be observed in vivo using phase contrast/flow imaging in MRI, (2) to develop and implement a cost-effective countermeasure that minimizes the risk of vertigo in high-strength MRI fields, and (3) to image the human labyrinth in 7T and 3T MRI combining anatomic and flow imaging sequences. The study will involve chinchillas in aim 1 and the recruitment of healthy human participants in aims 2 and 3. Completion of the proposed research plan will provide evidence for the cause of dizziness in strong MRI, a low-cost method to mitigate the effects of dizziness in an MRI regardless of the magnetic field strength, and support that improved MRI can provide higher resolution images of the labyrinth. At the conclusion of this award, the candidate will be well-positioned to compete successfully for funding, having acquired relevant knowledge and skills to become a leader in using high-strength MRI to identify new vestibular pathophysiology and improve diagnosis of common conditions that cause dizziness and vertigo.

摘要 博士布赖恩沃德是耳鼻咽喉头颈外科系的助理教授， 约翰霍普金斯医学院，在那里他致力于前庭疾病，耳科， 和神经耳科。他正在寻求一个指导职业发展奖，以填补知识空白， 使用MRI对内耳进行成像。他的长期目标是建立一个独立的研究计划， 致力于利用影像学来改善头晕和失衡患者的诊断和治疗。的 候选人建议扩大他以前的工作，研究强磁场的生理效应， 内耳前庭系统，以成像健康龙猫和人类迷路中的流体流动。的 培训计划使沃德博士沉浸在多学科研究和临床环境中 约翰霍普金斯大学医学院的放射学、神经学、生物医学工程学和耳鼻喉科 药具体培训目标包括：（1）接受MRI物理学和图像如何 获得，（2）完成MRI安全性培训并使用成像模式进行前瞻性研究，（3） 在研究的道德和负责任的行为方面进行额外的培训，以及（4）将他的临床 在他发展成为一名独立调查员的过程中，他接受了前庭疾病方面的培训。 高磁场MRI可以提高图像的空间和时间分辨率，因为增加了 信噪比;然而，这些MRI机器也会导致人类头晕和眩晕。我们 先前的研究表明，所有健康的人在MRI中都有眼球震颤，并假设这是由于 迷宫中的洛伦兹力。本研究的具体目的是：（1）检验 洛伦兹力引起流体流动的假设，可以使用相位对比/流动在体内观察到 MRI成像，（2）开发和实施一种具有成本效益的对策，最大限度地减少眩晕的风险 （3）在7 T和3 T MRI中结合解剖结构对人体迷路进行成像， 和流动成像序列。这项研究将涉及灰鼠在目标1和招募健康的人 目标2和3的参与者。完成拟议的研究计划将提供证据的原因 强MRI中的头晕，一种低成本的方法，以减轻头晕的影响，在MRI中，无论 磁场强度，并支持改进的MRI可以提供更高分辨率的迷路图像。 在这个奖项结束时，候选人将处于有利地位，成功地竞争资金， 获得相关知识和技能，成为使用高强度MRI识别新的 前庭病理生理学和提高诊断的常见条件，导致头晕和眩晕。