Laser Treatment Modality for Strengthening Osteoarthritic Cartilage
强化骨关节炎软骨的激光治疗方式
基本信息
- 批准号:10321592
- 负责人:
- 金额:$ 27.72万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-01-10 至 2023-12-31
- 项目状态:已结题
- 来源:
- 关键词:AblationActivities of Daily LivingAgeAmericanAnimalsBackBiologicalBiomechanicsBiomedical EngineeringBovine CartilageCartilageCartilage DiseasesCattleCell SurvivalChemical AgentsChondrocytesClinicalCollagenDataDebridementDefectDegenerative DisorderDegenerative polyarthritisDevelopmentDiseaseDisease ProgressionEffectivenessEnsureExhibitsExtracellular MatrixFemaleFiber OpticsFrictionFutureHealthHip OsteoarthritisHomeostasisHourHumanHydration statusImplantIn SituIn VitroIndividualJointsKnee OsteoarthritisLasersLongevityMainstreamingMethodologyModalityModificationModulusMorphologyNational Institute of Arthritis and Musculoskeletal and Skin DiseasesNude MiceOperative Surgical ProceduresOpticsOrganPainPathologicPatient-Focused OutcomesPlasmaPropertyProteinsProtocols documentationReactive Oxygen SpeciesReplacement ArthroplastyResearchResearch Project GrantsResistanceSafetyShockSideSurfaceSynovial FluidSystemTechnologyTestingThermal Ablation TherapyThickTissue ViabilityTissuesTranslatingVisualWaterWeight-Bearing stateWorkarticular cartilagebaseboneclinically relevantcrosslinkdensitydesigneffectiveness evaluationhuman maleimprovedin vivoionizationirradiationjoint functionmalemechanical propertiesnovelpre-clinicalprogramsrepairedresponsesafety assessmentsubchondral bonetool
项目摘要
Project Summary
Osteoarthritis (OA) is a debilitating degenerative disease that afflicts an estimated 27 million Americans age 25
and older. This disease leads to the progressive degradation of the articular layers of diarthrodial joints,
significantly compromising the main function of cartilage as a load bearing material, leading to pain and limiting
activities of daily living. To this day, there are very limited treatment options for slowing down the progression
of OA in its early stages. Most therapies, such as highly invasive partial and total joint replacement surgeries
are performed at the late stage of the disease. Introducing treatment options to earlier stages of OA presents
the potential to retard or slow down disease progression and thus significantly improve patient outcomes. The
primary function of articular cartilage is to transmit loads across the joint surfaces while simultaneously
minimizing friction and wear. This application describes the development of an ultrafast laser-based treatment
tool which has the ability to induce crosslinks into the cartilage collagen network without the addition of a
chemical agent, while simultaneously avoiding damaging effects of optical breakdown and ablation. Preliminary
data show that laser-induced crosslinks increase compressive stiffness and wear resistance, without
compromising cell viability, which may be expected to slow down progression of OA. The overall aim of this
application is to develop a range of effective and safe laser operating parameters that enhance cartilage
mechanical properties and wear resistance, enabling us to produce a clinically relevant protocol. We also aim
to assess the influence of laser-induced short-lived bursts of reactive oxygen species onto the long-term
response of cartilage during in vitro and in vivo culture. To translate this technology to future animal and
human studies, we will develop and test a laser-based clinical tool for arthroscopic treatment of cartilage in
situ. In specific aim 1, we will optimize a framework for structural, morphological and functional modification of
the cartilage extracellular matrix subject to femtosecond laser irradiation, using devitalized bovine and human
OA cartilage explants. In specific aim 2, we will narrow this range of operating parameters by testing short-term
and long-term viability of laser-treated live bovine and human OA (male & female) cartilage explants against
untreated controls, using in vitro culture up to 4 weeks. In specific aim 3, we will verify that laser-treated live
human OA cartilage explants exhibit comparable viability and health as untreated controls when implanted for
up to 8 weeks in the back of nude mice. We will also fabricate a fiber optic-based laser system and validate its
effectiveness in simulated in situ arthroscopic applications in OA knee joints. Upon completion of these
studies, we will have established effective and safe operating parameters for this novel laser treatment
modality, and created a practical tool to test this methodology in situ, first in large animals, then in humans.
项目总结
项目成果
期刊论文数量(0)
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会议论文数量(0)
专利数量(0)
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GERARD A. ATESHIAN其他文献
GERARD A. ATESHIAN的其他文献
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{{ truncateString('GERARD A. ATESHIAN', 18)}}的其他基金
Laser Treatment Modality for Strengthening Osteoarthritic Cartilage
强化骨关节炎软骨的激光治疗方式
- 批准号:
10321817 - 财政年份:2021
- 资助金额:
$ 27.72万 - 项目类别:
Laser Treatment Modality for Strengthening Osteoarthritic Cartilage
强化骨关节炎软骨的激光治疗方式
- 批准号:
10616042 - 财政年份:2019
- 资助金额:
$ 27.72万 - 项目类别:
Multidisciplinary Engineering Training in Musculoskeletal Research
肌肉骨骼研究的多学科工程培训
- 批准号:
8324567 - 财政年份:2011
- 资助金额:
$ 27.72万 - 项目类别:
Multidisciplinary Engineering Training in Musculoskeletal Research
肌肉骨骼研究的多学科工程培训
- 批准号:
8711285 - 财政年份:2011
- 资助金额:
$ 27.72万 - 项目类别:
Multidisciplinary Engineering Training in Musculoskeletal Research
肌肉骨骼研究的多学科工程培训
- 批准号:
8520182 - 财政年份:2011
- 资助金额:
$ 27.72万 - 项目类别:
Multidisciplinary Engineering Training in Musculoskeletal Research
肌肉骨骼研究的多学科工程培训
- 批准号:
8079260 - 财政年份:2011
- 资助金额:
$ 27.72万 - 项目类别:
Optimizing Nutrient Supply in Large Engineered Cartilage Tissue Constructs
优化大型工程软骨组织结构中的营养供应
- 批准号:
8025654 - 财政年份:2010
- 资助金额:
$ 27.72万 - 项目类别:
Optimizing Nutrient Supply in Large Engineered Cartilage Tissue Constructs
优化大型工程软骨组织结构中的营养供应
- 批准号:
8312731 - 财政年份:2010
- 资助金额:
$ 27.72万 - 项目类别:
Optimizing Nutrient Supply in Large Engineered Cartilage Tissue Constructs
优化大型工程软骨组织结构中的营养供应
- 批准号:
8145587 - 财政年份:2010
- 资助金额:
$ 27.72万 - 项目类别:
Optimizing Nutrient Supply in Large Engineered Cartilage Tissue Constructs
优化大型工程软骨组织结构中的营养供应
- 批准号:
8721343 - 财政年份:2010
- 资助金额:
$ 27.72万 - 项目类别:
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