权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Development of broad nanovaccines targeting diverse coronavirus receptor-binding sites

开发针对不同冠状病毒受体结合位点的广泛纳米疫苗

基本信息

批准号：
10328140
负责人：
Daniel Kulp
金额：
$ 124.45万
依托单位：
WISTAR INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-22 至 2025-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10328140
关键词：
2019-nCoV Address Adjuvant Antibodies Antibody Repertoire Antibody Response Antigens Automobile Driving B-Lymphocytes Binding Binding Sites CD8-Positive T-Lymphocytes COVID-19 therapeutics COVID-19 vaccination COVID-19 vaccine Coronavirus Coronavirus Infections Cryoelectron Microscopy DNA DNA Vaccines Development Devices Disease Outbreaks Dose Electroporation Epitopes Escape Mutant FDA Emergency Use Authorization Frequencies Generations Genetic Genetic Recombination Human Immune Sera Immune response Immunity Immunization Immunization Programs Investigation Libraries Middle East Respiratory Syndrome Coronavirus Modeling Molecular Mutagenesis Mutate Mutation Nucleic Acids Phenotype Preclinical Testing Publishing Regimen Research Project Grants SARS coronavirus SARS-CoV-2 spike protein Site Technology Transgenic Animals Vaccine Clinical Trial Vaccines Variant Virus Widespread Disease animal data base betacoronavirus clinical translation combat coronavirus receptor coronavirus vaccine cross reactivity design experimental study human coronavirus immunogenicity interest lead candidate mutant nanoparticle nanoparticle delivery nanovaccine neutralizing antibody novel novel coronavirus nucleic acid delivery pandemic disease pathogenic virus plasmid DNA pre-clinical programs receptor receptor binding synergism universal coronavirus vaccine vaccine candidate vaccine development vaccinology

项目摘要

Project Summary The first project of our pan-CoV proposal is titled ‘Development of broad nanovaccines targeting diverse coronavirus receptor-binding sites’. Our team’s expertise will culminate in structurally guided coronavirus nanoparticle vaccines to broaden CoV vaccine protection. This proposal utilizes our novel platform to develop potent, RBS-focused nanoparticle vaccines to induce broad protection across CoV lineages, escape mutations and potential pandemic CoVs that are of concern. The project aims are: (1) Create a library of mutants that escape coronavirus immunity (2) Develop RBS-focused nanoparticle vaccines to induce broadly neutralizing antibodies to conserved sites using nucleic acid delivery and (3) Develop vaccine regimens to induce broad immunity and protection across diverse CoVs.

项目摘要我们泛冠状病毒提案的第一个项目名为“开发针对多种疾病的广泛纳米疫苗”。冠状病毒受体结合位点。我们团队的专业知识将在结构引导的冠状病毒纳米颗粒疫苗扩大CoV疫苗保护。该提案利用我们的新平台，开发有效的、以RBS为焦点的纳米颗粒疫苗，以诱导跨CoV谱系的广泛保护，逃逸突变和潜在的大流行性冠状病毒。项目的目标是：（1）创建一个逃避冠状病毒免疫的突变体库（2）开发RBS聚焦的纳米颗粒疫苗，使用核酸递送针对保守位点的广泛中和抗体和（3）开发疫苗方案以在不同的CoV中诱导广泛的免疫和保护。