Development of broad nanovaccines targeting diverse coronavirus receptor-binding sites
开发针对不同冠状病毒受体结合位点的广泛纳米疫苗
基本信息
- 批准号:10328140
- 负责人:
- 金额:$ 124.45万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-09-22 至 2025-08-31
- 项目状态:未结题
- 来源:
- 关键词:2019-nCoVAddressAdjuvantAntibodiesAntibody RepertoireAntibody ResponseAntigensAutomobile DrivingB-LymphocytesBindingBinding SitesCD8-Positive T-LymphocytesCOVID-19 therapeuticsCOVID-19 vaccinationCOVID-19 vaccineCoronavirusCoronavirus InfectionsCryoelectron MicroscopyDNADNA VaccinesDevelopmentDevicesDisease OutbreaksDoseElectroporationEpitopesEscape MutantFDA Emergency Use AuthorizationFrequenciesGenerationsGeneticGenetic RecombinationHumanImmune SeraImmune responseImmunityImmunizationImmunization ProgramsInvestigationLibrariesMiddle East Respiratory Syndrome CoronavirusModelingMolecularMutagenesisMutateMutationNucleic AcidsPhenotypePreclinical TestingPublishingRegimenResearch Project GrantsSARS coronavirusSARS-CoV-2 spike proteinSiteTechnologyTransgenic AnimalsVaccine Clinical TrialVaccinesVariantVirusWidespread Diseaseanimal databasebetacoronavirusclinical translationcombatcoronavirus receptorcoronavirus vaccinecross reactivitydesignexperimental studyhuman coronavirusimmunogenicityinterestlead candidatemutantnanoparticlenanoparticle deliverynanovaccineneutralizing antibodynovelnovel coronavirusnucleic acid deliverypandemic diseasepathogenic virusplasmid DNApre-clinicalprogramsreceptorreceptor bindingsynergismuniversal coronavirus vaccinevaccine candidatevaccine developmentvaccinology
项目摘要
Project Summary
The first project of our pan-CoV proposal is titled ‘Development of broad nanovaccines targeting diverse
coronavirus receptor-binding sites’. Our team’s expertise will culminate in structurally guided coronavirus
nanoparticle vaccines to broaden CoV vaccine protection. This proposal utilizes our novel platform to
develop potent, RBS-focused nanoparticle vaccines to induce broad protection across CoV lineages,
escape mutations and potential pandemic CoVs that are of concern. The project aims are: (1) Create a
library of mutants that escape coronavirus immunity (2) Develop RBS-focused nanoparticle vaccines to induce
broadly neutralizing antibodies to conserved sites using nucleic acid delivery and (3) Develop vaccine regimens
to induce broad immunity and protection across diverse CoVs.
项目摘要
我们泛冠状病毒提案的第一个项目名为“开发针对多种疾病的广泛纳米疫苗”。
冠状病毒受体结合位点。我们团队的专业知识将在结构引导的冠状病毒
纳米颗粒疫苗扩大CoV疫苗保护。该提案利用我们的新平台,
开发有效的、以RBS为焦点的纳米颗粒疫苗,以诱导跨CoV谱系的广泛保护,
逃逸突变和潜在的大流行性冠状病毒。项目的目标是:(1)创建一个
逃避冠状病毒免疫的突变体库(2)开发RBS聚焦的纳米颗粒疫苗,
使用核酸递送针对保守位点的广泛中和抗体和(3)开发疫苗方案
以在不同的CoV中诱导广泛的免疫和保护。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Daniel Kulp其他文献
Daniel Kulp的其他文献
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{{ truncateString('Daniel Kulp', 18)}}的其他基金
Investigation into the activation of multiple bnAb precursors using structure-designed immunogens and Ig knock-in mice
使用结构设计的免疫原和 Ig 敲入小鼠研究多种 bnAb 前体的激活
- 批准号:
10619836 - 财政年份:2022
- 资助金额:
$ 124.45万 - 项目类别:
Structural vaccinology guided development of a universal CoV vaccine utilizing nucleic acid delivered nanoparticles
结构疫苗学指导利用核酸递送纳米粒子开发通用 CoV 疫苗
- 批准号:
10328138 - 财政年份:2022
- 资助金额:
$ 124.45万 - 项目类别:
Refinement of DNA-Launched NanoParticles decorated with Apex and CD4bs B cell lineage targeting Envs (DLNP-ACEs)
用 Apex 和 CD4bs B 细胞谱系靶向 Envs (DLNP-ACE) 修饰的 DNA 启动纳米粒子的精制
- 批准号:
10589588 - 财政年份:2022
- 资助金额:
$ 124.45万 - 项目类别:
Development of Broad Coronavirus Immunity Targeting the Fusion Peptide
针对融合肽的广泛冠状病毒免疫的开发
- 批准号:
10424573 - 财政年份:2021
- 资助金额:
$ 124.45万 - 项目类别:
Development of Broad Coronavirus Immunity Targeting the Fusion Peptide
针对融合肽的广泛冠状病毒免疫的开发
- 批准号:
10303447 - 财政年份:2021
- 资助金额:
$ 124.45万 - 项目类别:
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