A Complete Metal Artifact Reduced MRI Exam for Neuroimaging

用于神经影像学的完整金属制品简化 MRI 检查

• 批准号: 10327334
• 负责人: KEVIN M KOCH
• 金额: $ 19.5万
• 依托单位: MEDICAL COLLEGE OF WISCONSIN
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-02-01 至 2023-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10327334
• 关键词: Address; Aneurysm; Angiography; Attenuated; Brain imaging; Brain region; Cephalic; Childhood; Clinical Trials; Clip; Cochlear Implants; Creation of ventriculo-peritoneal shunt; Data; Dental; Development; Devices; Diagnostic; Diagnostic Imaging; Diffusion; Diffusion Magnetic Resonance Imaging; Fatty acid glycerol esters; Foundations; Future; Goals; Head; Image; Imaging Techniques; Imaging technology; Implant; Intention; Intervention; Ionizing radiation; Ions; Left; Liquid substance; Magnetic Resonance Angiography; Magnetic Resonance Imaging; Metals; Methods; Modality; Morphologic artifacts; Neurologic; Noise; Orthopedics; Participant; Patients; Performance; Predisposition; Proliferating; Protons; Randomized; Reaction; Reader; Recovery; Replacement Arthroplasty; Resolution; Risk; Shunt Device; Signal Transduction; Slice; T2 weighted imaging; Techniques; Technology; Testing; Time; Tissues; Translating; Translations; Ventricular; Weight; Work; X-Ray Computed Tomography; attenuation; base; brain magnetic resonance imaging; brain tissue; clinical examination; cohort; contrast imaging; cranium; density; diagnostic tool; diagnostic value; diffusion weighted; imaging approach; imaging capabilities; imaging modality; implant design; improved; interest; metallicity; musculoskeletal imaging; nervous system disorder; neuroimaging; novel; novel diagnostics; preservation; reconstruction; skull implant; soft tissue; spectrograph; standard of care; tau Proteins

Project Summary Techniques for reducing metal artifacts in magnetic resonance imaging (MRI) of orthopaedic implants have seen tremendous improvement in the last decade. Extensions of these technologies to other applications, including brain imaging, remain under-developed. As a result, MRI contrasts essential for neuroimaging – such as T2-FLAIR weighting, weighting, diffusion weighting, and angiography – have not been actively explored. At the same time, intra-cranial implants or devices which are safe to image have proliferated, and a growing number of neuroimaging exams include metal artifacts which render them non-diagnostic. It is the goal of this work to develop and optimize metal artifact reduced acquisitions for the deployment of a fully-functioning neuroimaging clinical exam. The first aim of the proposed work seeks to develop acquisitions and reconstructions for MRI contrasts which are needed for neuroimaging exams, and are not yet available. Currently available contrasts include T1-weighting, T2-weighting, and in a preliminary format, diffusion-weighting. For application to neuroimaging, similar metal artifact reduction principles will be leveraged to yield T2-FLAIR, -weighted, and angiographic acquisitions. Novel principles necessary for the development of the new proposed acquisitions have recently been demonstrated within the context of projects targeting orthpaedic implants. In this proposal, these new developments will be translated to address neuroimaging-specific applications. The second aim of the proposed study seeks to evaluate existing and new metal artifact reduction acquisi- tions for diagnostic performance in neuroimaging exams. Several quantitative metric comparisons between the conventional and proposed neurological MRI exams will be performed. Compared metrics will include artifact volume, signal to noise, and contrast to noise. Finally, the diagnostic performance of the newly proposed metal artifact mitigated neurological MRI exam will be evaluated in a randomized reader study. Completion of the proposed work could yield foundational technology necessary for a complete metal artifact reduced neurological MRI examination. Within the current study, this technology will be developed and tested to the point of appropriateness for future clinical trials to assess its performance as a primary diagnostic tool. Ultimately, this work will lead to the availability of new diagnostic neurological MRI exams in patients where current technologies yield non-diagnostic MRI data.

项目总结