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Cognitive Control Functions of the Human Thalamus

人类丘脑的认知控制功能

基本信息

批准号：
10326859
负责人：
Kai Hwang
金额：
$ 44.25万
依托单位：
UNIVERSITY OF IOWA
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-03-10 至 2024-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10326859
关键词：
Affect Anatomy Animal Model Anterior Attention deficit hyperactivity disorder Behavior Behavioral Brain Cell Nucleus Clinical Treatment Cognitive Corpus striatum structure Data Diagnosis Disease Exhibits Functional Magnetic Resonance Imaging Functional disorder Goals Human Image Impairment Individual Lead Lesion Maintenance Maps Mental disorders Mission Morphology Motor Neurocognitive Neurons Neuropsychology Neurosciences Pathway Analysis Patients Pattern Play Process Property Public Health Publishing Pulvinar structure Records Research Resolution Role Schizophrenia Short-Term Memory Specific qualifier value Stroke Structure System Task Performances Testing Thalamic Nuclei Thalamic structure To specify Traumatic Brain Injury United States National Institutes of Health base cognitive control cognitive function cognitive rigidity cognitive system cognitive task comparison group distraction experimental study functional magnetic resonance imaging/electroencephalography individual patient innovation insight member multimodal neuroimaging nervous system disorder novel strategies recruit relating to nervous system response translational neuroscience

项目摘要

PROJECT SUMMARY Cognitive control is an umbrella term that describes processes that regulate cognitive, perceptual, and motor functions needed to perform adaptive, goal-directed behaviors. Patients with neurological and psychiatric disorders, for example schizophrenia, attention-deficit hyperactivity disorder (ADHD), traumatic brain injury and stroke, suffer from impairments in cognitive control. Although the function of frontoparietal and striatal circuits in cognitive control have been extensively studied, increasing evidence suggests a role for the thalamus. Thalamic nuclei have reciprocal and non-reciprocal connections with multiple cortical regions, integrate modulatory inputs from other subcortical structures, and innervate both excitatory and inhibitory cortical neurons. Despite this prominent connectivity profile, the role of the human thalamus in cognitive control and effects of its dysfunction are not well understood. The objective of the proposed research is to determine the cognitive control functions of the human thalamus. Our central hypothesis, based on our extensive preliminary data and anatomical properties of thalamocortical circuits in animal models, is that thalamic nuclei support cognitive control by modulating cortical activities that include evoked responses, cortical network interactions, and neural oscillations. These cortical activities instantiate neurocognitive processes that select or maintain task-relevant information, and they can be selectively amplified through targeted increases in thalamocortical interactions. Consequently, thalamocortical dysfunction can lead to cognitive rigidity, increased distraction, and poor planning. To test our hypothesis, we propose a novel approach that integrates cognitive behavioral tasks that specifically manipulate processes that select and maintain task-relevant information (for example, working memory and set switching), multimodal neuroimaging (fMRI and EEG), and human thalamic lesions studies. We will first determine the functional organization (topography) of thalamocortical functional connectivity for cognitive control (Aim 1), which has not yet been systematically mapped in humans. We will then determine how thalamocortical interactions select and maintain task-relevant information by examining its relationship with, and modulatory effects on, task- related cortical activities (Aims 2 and 3). For all studies, we will recruit healthy individuals, patients with focal thalamic lesions, and control patients from a lesion comparison group. By collecting multimodal neuroimaging data from patients with focal thalamic lesions, we will determine how the disruption of thalamocortical interactions affects task-related cortical neural activities and behavior. Results from our proposed research will establish how the distribution of thalamocortical connectivity enables thalamic nuclei to participate in multiple cognitive control functions, and specify the cognitive and neural repercussions of thalamocortical dysfunction observed in patients with thalamic stroke, as well as other disorders such as ADHD and schizophrenia.

项目总结