Noninvasive transcranial detection of intracranial hemorrhage using a tri-coil handheld portable eddy current damping imaging device

使用三线圈手持式便携式涡流阻尼成像装置对颅内出血进行无创经颅检测

• 批准号: 10329954
• 负责人: Gabriel Zada
• 金额: $ 38.9万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-01-15 至 2025-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10329954
• 关键词: Address; Affect; Alteplase; American; American Heart Association; Anatomic Models; Brain; Brain hemorrhage; Cadaver; Cause of Death; Cerebral hemisphere hemorrhage; Cerebrum; Cessation of life; Characteristics; Clinical; Coma; Confusion; Consumption; Data; Detection; Deterioration; Devices; Diagnosis; Diagnostic; Diagnostic Imaging; Dose; Effectiveness; Frequencies; Gelatin; Goals; Grouping; Guidelines; Health system; Hemorrhage; Hospitals; Hour; Human; Image; Image Analysis; Imaging Device; Injury; Institutional Review Boards; International; Intervention; Intracranial Hemorrhages; Ischemic Stroke; Joints; Journals; Knowledge; Lesion; Life; Location; Magnetic Resonance Imaging; Measures; Medical; Medical Device; Methods; Modeling; Morbidity - disease rate; Nervous System Trauma; Neurologic; Neurological emergencies; Neurosurgeon; Outcome; Output; Participant; Patients; Pharmaceutical Preparations; Physicians; Pre-Clinical Model; Productivity; Property; Protocols documentation; Provider; Publishing; Quality of life; Reporting; Savings; Scanning; Scientist; Shapes; Societies; Stroke; Technology; Testing; Time; Tissues; Translating; Translational Research; Traumatic Brain Injury; Triage; United States National Institutes of Health; Validation; Variant; X-Ray Computed Tomography; acute care; base; brain parenchyma; brain tissue; clinical investigation; cost; cranium; detection platform; diagnostic accuracy; diagnostic value; disability; disorder subtype; experience; experimental study; imaging detection; imaging system; improved; innovation; instrument; ischemic lesion; laboratory experiment; machine learning algorithm; magnetic field; meetings; method development; models and simulation; mortality; multidisciplinary; neuroimaging; non-invasive imaging; novel; portability; predictive modeling; rapid technique; research clinical testing; response; sensor; stroke model; stroke patient; stroke therapy; symposium; temporal measurement

Project Summary: Noninvasive transcranial detection of intracranial hemorrhage using a tri-coil handheld portable eddy current damping imaging device Stroke and traumatic brain injury (TBI) are common causes of death and permanent disability worldwide, costing the U.S. health system more than $71 billion per year in lost productivity and medical expenses. Existing paradigms for stroke/TBI diagnosis require computed tomography (CT) or magnetic resonance (MR) imaging to classify ischemic versus hemorrhagic variants prior to intervention, as treatment for these conditions varies widely. Delays in diagnosis and issues related to transport of unstable patients associated with diagnostic imaging increase the likelihood of neurological injury and death. Translational medical devices that accelerate time-to-treatment in the field or hospital setting may help to reduce morbidity and mortality in stroke/TBI patients on a global level. Our team has developed a portable, rapid and noninvasive imaging and detection device based on eddy current damping (ECD) sensors that can detect brain hemorrhages associated with stroke and TBI, and have demonstrated feasibility in a benchtop, human cadaver and clinical patient setting. This device can potentially diagnose and classify hemorrhagic stroke/TBI subtypes with accurate spatial localization in minutes, rather than hours, thereby guiding early responders and medical providers in making time-sensitive medical decisions for clinical intervention, such as administration of tissue plasminogen activator for ischemic stroke. Our overall goal is to demonstrate the effectiveness of this novel stroke detection device in rapidly triaging stroke/TBI patients and achieving a level of diagnostic accuracy capable of guiding clinical intervention. We hypothesize that: 1) Regional conductivity changes in brain tissue can be imaged and detected using the portable ECD sensor; 2) Hemorrhagic stroke and TBI-related hemorrhages will increase regional conductivity, whereas ischemic stroke will decrease dependent brain conductivity in affected ischemic regions; and 3) Portable stroke imaging may reduce time-to-treatment and diagnosis associated with stroke/TBI. To test these hypotheses, we aim to: 1) Perform benchtop laboratory experiments to further elucidate how direction and magnitude of measured conductivity changes can differentiate stroke subtype and location, 2) Use validated human cadaver stroke simulation models to optimize ECD tri-coil array sensor detection of hemorrhage depth, volume, and location, 3) Utilize machine learning algorithms to quickly classify brain lesions with high accuracy, and 4) Implement early clinical stroke/TBI ECD sensor device testing to gauge effectiveness in live human patients, compared to CT/MR imaging. Development of methods for rapid bedside stroke/TBI diagnosis will provide practitioners with knowledge required to rapidly administer life-saving treatments, thereby improving patient quality of life and survival. Knowledge derived from this will help to reduce time-to-treatment and guide triage and intervention, which is likely to translate to improved morbidity and mortality associated with these common conditions.

项目摘要：使用三线圈手持式无创经颅检测颅内出血 便携式涡流阻尼成像装置 中风和创伤性脑损伤 (TBI) 是全世界死亡和永久性残疾的常见原因， 美国医疗系统每年因生产力损失和医疗费用损失超过 710 亿美元。现存的 中风/TBI 诊断范例需要计算机断层扫描 (CT) 或磁共振 (MR) 成像 在干预前对缺血性变异和出血性变异进行分类，因为这些病症的治疗方法各不相同 广泛。诊断延误以及与诊断相关的不稳定患者的转运相关问题 成像增加神经损伤和死亡的可能性。加速转化的医疗设备 现场或医院环境中的治疗时间可能有助于降低中风/TBI 患者的发病率和死亡率 在全球层面上。我们的团队开发了一种便携式、快速、无创的成像和检测设备 涡流阻尼 (ECD) 传感器可以检测与中风和 TBI 相关的脑出血，以及 已在台式、人体尸体和临床患者环境中证明了可行性。该设备可以 可以在几分钟内通过准确的空间定位对出血性中风/TBI 亚型进行诊断和分类， 而不是几个小时，从而指导早期响应者和医疗提供者做出对时间敏感的医疗 临床干预的决策，例如使用组织纤溶酶原激活剂治疗缺血性中风。我们的 总体目标是证明这种新型中风检测装置在快速分类中风/TBI 方面的有效性 患者并达到能够指导临床干预的诊断准确性水平。我们假设 1) 使用便携式 ECD 可以对脑组织的区域电导率变化进行成像和检测 传感器; 2）出血性中风和TBI相关的出血会增加局部电导率，而 缺血性中风会降低受影响缺血区域的依赖性脑电导率； 3) 便携式行程 成像可以减少与中风/TBI 相关的治疗和诊断时间。为了检验这些假设，我们 目标是： 1) 进行台式实验室实验，以进一步阐明 测量的电导率变化可以区分中风亚型和位置，2) 使用经过验证的人体尸体 中风模拟模型，用于优化 ECD 三线圈阵列传感器对出血深度、体积和出血的检测 定位，3）利用机器学习算法快速高精度地对脑部病变进行分类，4） 实施早期临床中风/TBI ECD 传感器设备测试，以评估活体患者的有效性， 与 CT/MR 成像相比。快速床边卒中/TBI 诊断方法的开发将提供 具有快速实施挽救生命治疗所需知识的从业者，从而改善患者的状况 生活质量和生存。由此获得的知识将有助于缩短治疗时间并指导分诊 和干预，这可能会转化为改善与这些常见问题相关的发病率和死亡率 状况。