Risk Factors and Outcomes Associated with Late-Life Diabetic Peripheral Neuropathy

项目摘要/摘要 凯特琳·希克斯，医学博士，约翰·霍普金斯大学外科助理教授 医学院。她寻求K23导师以患者为导向的研究职业发展奖 获得作为内科科学家的独立职业生涯所需的基本技能和指导研究经验 糖尿病和腿部疾病领域。她的研究提案详细说明了一项旨在 一大批黑人中糖尿病周围神经病变的流行病学特征和危险因素 以及患有2型糖尿病的白人老年人。研究议程的具体目标是：1)严格 评估与老年糖尿病周围神经病变相关的危险因素；2)量化前瞻性 糖尿病周围神经病变与心血管事件、认知功能障碍、 和老年人7-8年随访期间的死亡；以及3)确定新的血浆蛋白生物标志物 使用高通量蛋白质组技术与老年糖尿病周围神经病变相关。本研究 将全面评估糖尿病周围神经病变与死亡率、心血管疾病之间的联系 社区环境中的事件、认知衰退和痴呆症，并确定新的生物标志物 与糖尿病周围神经病变相关，可能为病理生理提供信息并作为潜在靶点 在未来的研究中进行干预。作为她指导的职业发展的一部分，希克斯博士将接受深入的 在伊丽莎白博士的指导下进行先进流行病学方法和蛋白质组学研究的培训 塞尔文，博士，最高时速。希克斯博士近期的职业目标包括发展队列研究方面的专业知识， 生物统计分析和先进的流行病学方法，在设计和分析 生物标记物和蛋白质组学研究，并与临床建立地方、国家和国际合作 在相似和互补的研究/专长领域的研究人员。从长远来看，希克斯博士的目标是改善 我们对老年人糖尿病周围神经病变的流行病学和病理生理学的了解， 并在这一领域制定独立的研究计划。

PROJECT SUMMARY/ABSTRACT Caitlin Hicks MD, MS is an Assistant Professor in the Department of Surgery at the Johns Hopkins University School of Medicine. She seeks a K23 Mentored Patient-Oriented Research Career Development Award to obtain essential skills and mentored research experience for an independent career as a physician scientist in the field of diabetes and lower extremity disease. Her research proposal details a five-year plan aimed characterizing the epidemiology and risk factors for diabetic peripheral neuropathy in a large cohort of black and white older adults with type 2 diabetes. The specific aims of the research agenda are to: 1) Rigorously evaluate risk factors associated with late-life diabetic peripheral neuropathy; 2) Quantify the prospective associations of diabetic peripheral neuropathy with risk of incident cardiovascular events, cognitive impairment, and death during 7-8 years of follow-up in older adults; and 3) Identify novel plasma protein biomarkers associated with late-life diabetic peripheral neuropathy using high-throughput proteomic technology. This study will comprehensively evaluate the link between diabetic peripheral neuropathy and mortality, cardiovascular events, cognitive decline, and dementia in a community-based setting, and identify novel biomarkers associated with diabetic peripheral neuropathy that may inform pathophysiology and serve as potential targets for interventions in future studies. As part of her mentored career development, Dr. Hicks will receive in-depth training in advanced epidemiologic methods and proteomics research under the mentorship of Dr. Elizabeth Selvin, PhD, MPH. Dr. Hicks’ immediate career goals include developing expertise in cohort studies, biostatistical analysis, and advanced epidemiologic methods, gaining experience in the design and analysis of biomarker and proteomics research, and building local, national, and international collaborations with clinical researchers in similar and complementary areas of research/expertise. Long-term, Dr. Hicks aims to improve our understanding of the epidemiology and pathophysiology of diabetic peripheral neuropathy in older adults, and develop an independent research program in this area.