Risk Factors and Outcomes Associated with Late-Life Diabetic Peripheral Neuropathy

项目总结/摘要 Caitlin Hicks医学博士，理学硕士，约翰霍普金斯大学外科系助理教授 医学院。她寻求K23指导的以患者为导向的研究职业发展奖， 获得基本技能和指导的研究经验，作为一名医生科学家的独立职业生涯， 糖尿病和下肢疾病领域。她的研究提案详细说明了一项旨在 在一个大型黑人队列中描述糖尿病周围神经病变的流行病学和危险因素 和患有2型糖尿病的白色老年人。研究议程的具体目标是：1）严格 评估与晚期糖尿病周围神经病变相关的危险因素; 2）量化前瞻性 糖尿病周围神经病变与心血管事件、认知功能障碍 老年人7-8年随访期间的死亡率;和3）鉴定新的血浆蛋白生物标志物 与晚期糖尿病周围神经病变相关的研究。本研究 将全面评估糖尿病周围神经病变与死亡率、心血管疾病、 事件，认知能力下降和痴呆症，并确定新的生物标志物 与糖尿病周围神经病变相关，可能为病理生理学提供信息，并作为潜在靶点 在未来的研究中进行干预。作为她的指导职业发展的一部分，希克斯博士将获得深入的 在伊丽莎白博士的指导下接受先进流行病学方法和蛋白质组学研究的培训 Selvin，PhD，MPH.希克斯博士的近期职业目标包括发展队列研究方面的专业知识， 生物统计学分析，先进的流行病学方法，获得经验的设计和分析， 生物标志物和蛋白质组学研究，并建立地方，国家和国际合作，与临床 研究/专业知识相似和互补领域的研究人员。长期来看，希克斯博士的目标是改善 我们对老年人糖尿病周围神经病变的流行病学和病理生理学的了解， 并在这一领域开展独立的研究项目。

PROJECT SUMMARY/ABSTRACT Caitlin Hicks MD, MS is an Assistant Professor in the Department of Surgery at the Johns Hopkins University School of Medicine. She seeks a K23 Mentored Patient-Oriented Research Career Development Award to obtain essential skills and mentored research experience for an independent career as a physician scientist in the field of diabetes and lower extremity disease. Her research proposal details a five-year plan aimed characterizing the epidemiology and risk factors for diabetic peripheral neuropathy in a large cohort of black and white older adults with type 2 diabetes. The specific aims of the research agenda are to: 1) Rigorously evaluate risk factors associated with late-life diabetic peripheral neuropathy; 2) Quantify the prospective associations of diabetic peripheral neuropathy with risk of incident cardiovascular events, cognitive impairment, and death during 7-8 years of follow-up in older adults; and 3) Identify novel plasma protein biomarkers associated with late-life diabetic peripheral neuropathy using high-throughput proteomic technology. This study will comprehensively evaluate the link between diabetic peripheral neuropathy and mortality, cardiovascular events, cognitive decline, and dementia in a community-based setting, and identify novel biomarkers associated with diabetic peripheral neuropathy that may inform pathophysiology and serve as potential targets for interventions in future studies. As part of her mentored career development, Dr. Hicks will receive in-depth training in advanced epidemiologic methods and proteomics research under the mentorship of Dr. Elizabeth Selvin, PhD, MPH. Dr. Hicks’ immediate career goals include developing expertise in cohort studies, biostatistical analysis, and advanced epidemiologic methods, gaining experience in the design and analysis of biomarker and proteomics research, and building local, national, and international collaborations with clinical researchers in similar and complementary areas of research/expertise. Long-term, Dr. Hicks aims to improve our understanding of the epidemiology and pathophysiology of diabetic peripheral neuropathy in older adults, and develop an independent research program in this area.