Next-Generation Phylodynamics-targeted Partner Service Models for Combined HIV Prevention
Next-Generation Phylodynamics-targeted Partner Service Models for Combined HIV Prevention
批准号:
10329898
负责人:
Nanette Dior Benbow
金额:
$78.62万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2018
资助国家:
美国
项目状态:
已结题
起止时间:
2018-02-06 至 2024-01-31
关键词:
AIDS preventionAddressAttentionCaringCategoriesCenters for Disease Control and Prevention (U.S.)ChicagoClinicalCollaborationsContinuity of Patient CareDataDisease OutbreaksEffectivenessEnvironmentEpidemicFutureGeneticGenotypeGoalsGrowthHIVHIV SeronegativityHIV SeropositivityHIV diagnosisHIV resistanceHIV-1HealthHealth ResourcesIndividualInjecting drug userInterventionInvestigationModelingMolecularMolecular AnalysisOutcomePersonsPhylogenetic AnalysisPopulationPreventionProceduresProcessPublic HealthRecommendationResearchRiskSeriesService delivery modelServicesSocial NetworkSourceTestingTimeUnited StatesViral Load resultacute infectionbasecohortcostimprovedinnovationlongitudinal analysismembernext generationpre-exposure prophylaxispreventpreventive interventionpublic health interventionrandomized trialrecruitrelative effectivenessresponsestandard of caretransmission processtreatment as preventionworking groupyoung men who have sex with men
中文摘要
以系统动力学为目标的合作伙伴服务模型(P2M)项目旨在指导和快速转变
英文摘要
The Phylodynamics-targeted Partner service Models (P2M) project aims to guide and transform the rapidly
evolving public health implementation of molecular HIV surveillance (MHS) based prevention interventions as a
critical step towards HIV elimination. P2M seeks to study and optimize emerging new national guidance: The
CDC's March 2017 recommendations of the HIV Cluster Guidance Working Group on health department
implementation of MHS with clinical HIV resistance genotypes, now recommended at entry to care. These HIV-1
pol sequences can be used to identify “molecular clusters” of persons with genetically similar HIV. The
overarching goal of MHS is to identify persons within the risk environment. These persons are potential sources,
or recipients, of new HIV transmissions, and defined as: 1) new HIV seropositives (including recent/acute
infections); 2) previously known HIV seropositives with detectable viral load (in care or not); and 3) at-risk HIV
seronegatives. The yield of these persons in the risk environment is an important metric of the usefulness of
MHS-based partner services or other network recruitment procedures (ie 2-step) that will be examined in P2M.
Thus, P2M aims to rigorously test the hypotheses that: (a) analyzing molecular cluster data closer to time of HIV
diagnosis will increase the yield of risk environment members; and (b) targeted prevention using advanced
partner and network service approaches our team has innovated will also increase yield and improve
effectiveness of public health combination interventions. It is not feasible, however, to conduct a series of
randomized trials to test these hypotheses. Modeling approaches, however, are best suited for providing
guidance when multiple approaches and conceivable conditions exist, the contexts do not lend themselves to
research trials, and where multiple downstream outcomes are possible. For P2M, members of this multi-
institutional investigative team (from Houston and Chicago) will build upon existing HIV TRACE collaborations,
observational cohorts of populations most impacted by HIV and an existing Agent-Based HIV transmission
model (ABM) to guide and prioritize interventions. Accordingly, we aim to: Aim 1) Determine the relative
effectiveness of partner services targeted to HIV TRACE derived molecular clusters compared to partner
services as currently delivered without molecular cluster targeting (standard of care) to yield persons in the risk
environment. Aim 2) Optimize several cluster size and time thresholds by parameterizing an agent-based
model with existing cohort data that best yield categories of individuals in the risk environment based upon: 1)
time-to-molecular cluster identification; 2) molecular cluster number and size; and 3) real-time versus delayed
partner services response to cluster growth. Aim 3a) Model relative effectiveness of combined molecular
surveillance and next-generation partner services – 2-step, 3-step and social network referral – that best yield
persons in the risk environment; Aim 3b) Explore simulated HIV prevention interventions (ie. PrEP) and their
cost as they are modeled within real-world molecular cluster and partner/network service strategies.
期刊论文(3)
专著(0)
科研奖励(0)
会议论文
DOI:
10.1007/s10461-021-03525-0
发表时间:
2022-06
期刊:
AIDS AND BEHAVIOR
影响因子:
4.4
作者:
[Gore, Daniel J., Schueler, Kellie, Ramani, Santhoshini, Uvin, Arno, Phillips, Gregory, McNulty, Moira, Fujimoto, Kayo, Schneider, John]
通讯作者:
Schneider, John
DOI:
10.1016/j.socnet.2021.05.003
发表时间:
2022-01
期刊:
Social networks
影响因子:
3.1
作者:
[Fujimoto K, Paraskevis D, Kuo JC, Hallmark CJ, Zhao J, Hochi A, Kuhns LM, Hwang LY, Hatzakis A, Schneider JA]
通讯作者:
Schneider JA
The Sociostructural Implementation Science Coordination Initiative
-
批准号:10744378
-
项目类别:
-
资助金额:$120.09万
-
财政年份:2023
-
负责人:Nanette Dior Benbow
-
依托单位:
Promoting Sustained Viral Suppression Through Implementation of an Adapted Evidence-Informed Low-Barrier Care Model in a System of HIV Primary Care Clinics
-
批准号:10462394
-
项目类别:
-
资助金额:$89.86万
-
财政年份:2022
-
负责人:Nanette Dior Benbow
-
依托单位:
Promoting Sustained Viral Suppression Through Implementation of an Adapted Evidence-Informed Low-Barrier Care Model in a System of HIV Primary Care Clinics
-
批准号:10675620
-
项目类别:
-
资助金额:$79.14万
-
财政年份:2022
-
负责人:Nanette Dior Benbow
-
依托单位:
Disease Programs through Assessment, Assurance, Policy Development, and Prevention Strategies (STD AAPPS)
-
批准号:8788240
-
项目类别:
-
资助金额:$211.81万
-
财政年份:2014
-
负责人:Nanette Dior Benbow
-
依托单位:
SEXUALLY TRANSMITTED DISEASE PREVENTION
-
批准号:8734002
-
项目类别:
-
资助金额:$215.79万
-
财政年份:2014
-
负责人:Nanette Dior Benbow
-
依托单位:
HUMAN IMMUNODEFICIENCY VIRUS (HIV) ACQUIRED IMMUNODEFICIENCY VIRUS SYNDROME AIDS)
-
批准号:8599397
-
项目类别:
-
资助金额:$138.51万
-
财政年份:2013
-
负责人:Nanette Dior Benbow
-
依托单位:
HUMAN IMMUNODEFICIENCY VIRUS (HIV) ACQUIRED IMMUNODEFICIENCY VIRUS SYNDROME AIDS)
-
批准号:8521773
-
项目类别:
-
资助金额:$138.51万
-
财政年份:2013
-
负责人:Nanette Dior Benbow
-
依托单位:
HIv Behavioral Surveillance
-
批准号:8410921
-
项目类别:
-
资助金额:$59.36万
-
财政年份:2011
-
负责人:Nanette Dior Benbow
-
依托单位:
Minority AIDS Initiative Targeted Capacity Enhancement ECHPP
-
批准号:8485432
-
项目类别:
-
资助金额:$0.0万
-
财政年份:2011
-
负责人:Nanette Dior Benbow
-
依托单位:
HIV BEHAVIORAL SURVEILLANCE
-
批准号:8401844
-
项目类别:
-
资助金额:$42.61万
-
财政年份:2011
-
负责人:Nanette Dior Benbow
-
依托单位:
HIV BEHAVIORAL SURVEILLANCE
-
批准号:8597974
-
项目类别:
-
资助金额:$50.77万
-
财政年份:2011
-
负责人:Nanette Dior Benbow
-
依托单位:
HIV BEHAVIORAL SURVEILLANCE
-
批准号:8129286
-
项目类别:
-
资助金额:$59.79万
-
财政年份:2011
-
负责人:Nanette Dior Benbow
-
依托单位:
HIV BEHAVIORAL SURVEILLANCE
-
批准号:8207311
-
项目类别:
-
资助金额:$47.48万
-
财政年份:2011
-
负责人:Nanette Dior Benbow
-
依托单位:
MEDICAL MONITORING PROJECT (MMP)
-
批准号:8080491
-
项目类别:
-
资助金额:$46.11万
-
财政年份:2009
-
负责人:Nanette Dior Benbow
-
依托单位:
MEDICAL MONITORING PROJECT (MMP)
-
批准号:8473710
-
项目类别:
-
资助金额:$45.61万
-
财政年份:2009
-
负责人:Nanette Dior Benbow
-
依托单位:
MEDICAL MONITORING PROJECT (MMP)
-
批准号:8271237
-
项目类别:
-
资助金额:$49.43万
-
财政年份:2009
-
负责人:Nanette Dior Benbow
-
依托单位:
PS09-902 COMPREHENSIVE STD PREVENTION SYSTEMS (CSPS)
-
批准号:8208435
-
项目类别:
-
资助金额:$228.52万
-
财政年份:2009
-
负责人:Nanette Dior Benbow
-
依托单位:
MEDICAL MONITORING PROJECT (MMP)
-
批准号:7847582
-
项目类别:
-
资助金额:$48.76万
-
财政年份:2009
-
负责人:Nanette Dior Benbow
-
依托单位:
MEDICAL MONITORING PROJECT (MMP)
-
批准号:7787209
-
项目类别:
-
资助金额:$48.76万
-
财政年份:2009
-
负责人:Nanette Dior Benbow
-
依托单位:
MEDICAL MONITORING PROJECT (MMP)
-
批准号:8815142
-
项目类别:
-
资助金额:$45.61万
-
财政年份:2009
-
负责人:Nanette Dior Benbow
-
依托单位:
海外基金