DREAM: Discovering cancer Risks from Environmental contaminants And Maternal/child health

项目概要/摘要 UCSF发现环境污染物和母婴健康的癌症风险 （梦想）队列将提高我们对环境化学品多重暴露的理解， 不同人群中的孕妇及其后代的污染物与癌症风险有关。我们将 招募并跟踪一个经济上、地理上、种族上和种族上多样化的孕妇参与者库， 在旧金山弗朗西斯科湾区和加州的中央谷的妇女和他们的孩子。因为怀孕 诱导多种母体激素和生理变化，可增加癌症易感性， 环境化学品暴露，我们将重点放在怀孕作为一个时期，特别容易受到有毒 剂.我们将从2009年第二季度开始收集问卷数据和生物标本样本。 怀孕直到孩子满四岁。我们还将建立一个队列大使计划， 邀请我们三个网站的参与者提供持续的反馈，我们将把这些反馈整合到我们的研究中 优先事项我们的具体目标旨在解决暴露于环境化学品的假设， 在这一重要生命阶段扰乱内分泌系统和其他系统， 癌症，如通过中等癌症风险生物标志物鉴定的。我们的环境曝光将集中在两个方面 主要成分：消费品相关化学品（包括全氟烷基和多氟烷基物质[PFAS]， 邻苯二甲酸酯和增塑剂、酚类化合物、杀虫剂和芳香胺） 根据广泛的公众接触情况确定优先次序;以及空气和水中的环境污染物， 通过地理信息系统分析参与者的居住历史。我们的成果将侧重于 未来癌症发病风险的生物标志物，包括：短期结果，重点关注与关键 作为中等癌症风险生物标志物的特征（免疫应答和慢性炎症， 氧化应激和DNA损伤、激素破坏/受体介导的效应和细胞永生化）。为 长期的结果，我们将把队列参与者与加州全州范围内基于人口的癌症登记处联系起来， 医院出院数据、生命记录和Medi-Cal文件，以确定 癌症及相关疾病。我们的多学科合作建立在我们广泛的知识和 关于怀孕期间环境接触和环境影响的大规模研究经验 癌症的危险因素。我们提出的队列发展和研究计划将促进我们对 地理位置和人口结构多样化的年轻群体中存在多种污染物暴露，因此， 提高我们对致癌物敏感性的认识，这些敏感性与特定结果有关。 关键和未充分研究的时期，再加上一个平台，将允许灵活性和未来的合作， 随着新科学的出现，加强我们的研究。

Project Summary/Abstract The UCSF Discovering cancer Risks from Environmental contaminants And Maternal/child health (DREAM) cohort will enhance our understanding of how multiple exposures to environmental chemicals and pollutants across a diverse population of pregnant women and their offspring are linked to cancer risks. We will enroll and follow an economically, geographically, ethnically, and racially diverse participant pool of pregnant women and their children in the San Francisco Bay Area and California’s Central Valley. Because pregnancy induces multiple maternal hormonal and physiological changes that can increase cancer susceptibility to environmental chemical exposures, we will focus on pregnancy as a period of particular vulnerability to toxic agents. We will collect questionnaire data and biospecimen samples starting at the second trimester of pregnancy up until the child reaches four years of age. We will also establish a Cohort Ambassador Program to invite participants across our three sites to provide continuous feedback which we will integrate into our research priorities. Our specific aims are designed to address the hypothesis that exposures to environmental chemicals that disrupt endocrine and other systems during this important life phase predispose women and children to cancer, as identified via intermediate cancer risk biomarkers. Our environmental exposures will focus on two major components: Consumer product related chemicals (including per- and polyfluoroalkyl substances [PFAS], phthalates and plasticizers, phenolic compounds, pesticides, and aromatic amines) measured via biomonitoring and prioritized based on widespread public exposure; and environmental pollutants in air and water, evaluated via geographic information system analyses of participants’ residential histories. Our outcomes will focus on biomarkers of risk for future cancer incidence including: short-term outcomes focusing on associations with key characteristics that are intermediate cancer risk biomarkers (immune response and chronic inflammation, oxidative stress and DNA damage, hormone disruption/receptor mediated effects, and cell immortalization). For longer term outcomes we will link cohort participants to California’s statewide population-based cancer registry, hospital discharge data, vital records, and Medi-Cal files in later years of the project to identify diagnoses of cancer and related conditions. Our multidisciplinary collaboration is built on our extensive knowledge and experience conducting large-scale research on environmental exposures during pregnancy and environmental risk factors for cancer. Our proposed cohort development and research plan will advance our understanding of multiple pollutant exposures in a young geographically and demographically diverse cohort, thus substantially advancing our knowledge on enhanced susceptibility to carcinogens linked to specific outcomes during these critical and understudied periods, combined with a platform that will allow flexibility and future collaboration to enhance our study as new science emerges.