DREAM: Discovering cancer Risks from Environmental contaminants And Maternal/child health

项目摘要/摘要 加州大学旧金山分校发现环境污染物和母婴健康带来的癌症风险 (梦想)队列将增强我们对多次暴露于环境化学品和 不同人群中的孕妇及其后代的污染物与癌症风险有关。我们会 登记并关注经济、地理、民族和种族不同的孕妇参与者池 旧金山湾区和加州中央山谷的妇女和她们的孩子。因为怀孕 引起多种母体激素和生理变化，从而增加癌症的易感性 环境中的化学物质暴露，我们将把重点放在怀孕这段时期，因为它特别容易受到有毒物质的伤害 探员们。我们将从怀孕的第二个月开始收集问卷数据和生物量样本。 怀孕到孩子四岁为止。我们还将建立一个联合大使计划，以 邀请我们三个站点的参与者提供持续反馈，我们将把这些反馈整合到我们的研究中 优先事项。我们的具体目标是解决这样一种假设，即暴露在环境化学品中 在这个重要的生命阶段扰乱内分泌和其他系统，使妇女和儿童容易患上 癌症，通过中等癌症风险生物标记物识别。我们的环境暴露将集中在两个方面 主要成分：消费品相关化学品(包括全氟烷基和多氟烷基物质[PFAS]， 邻苯二甲酸酯和增塑剂、酚类化合物、农药和芳香胺)通过生物监测进行测量 并根据广泛的公众接触情况确定优先顺序；以及评估空气和水中的环境污染物 通过地理信息系统对参与者的居住史进行分析。我们的成果将集中在 未来癌症发病率的生物标记物包括：关注与关键疾病相关的短期结果 属于中等癌症风险生物标志物的特征(免疫反应和慢性炎症， 氧化应激和DNA损伤、激素干扰/受体介导的效应，以及细胞永生化)。为 长期结果我们将把队列参与者与加州全州范围内基于人口的癌症登记联系起来， 项目后期的医院出院数据、生命记录和Medi-Cal档案，以确定诊断 癌症及相关疾病。我们的多学科合作建立在我们广博的知识和 开展孕期环境暴露和环境暴露大规模研究的经验 癌症的风险因素。我们建议的队列开发和研究计划将促进我们对 在年轻的地理和人口结构不同的队列中接触多种污染物，因此基本上 增进我们对致癌物易感性的知识，这些结果与这些 关键时期和未得到充分研究的时期，与一个将允许灵活性和未来协作的平台相结合 随着新科学的出现，加强我们的学习。

Project Summary/Abstract The UCSF Discovering cancer Risks from Environmental contaminants And Maternal/child health (DREAM) cohort will enhance our understanding of how multiple exposures to environmental chemicals and pollutants across a diverse population of pregnant women and their offspring are linked to cancer risks. We will enroll and follow an economically, geographically, ethnically, and racially diverse participant pool of pregnant women and their children in the San Francisco Bay Area and California’s Central Valley. Because pregnancy induces multiple maternal hormonal and physiological changes that can increase cancer susceptibility to environmental chemical exposures, we will focus on pregnancy as a period of particular vulnerability to toxic agents. We will collect questionnaire data and biospecimen samples starting at the second trimester of pregnancy up until the child reaches four years of age. We will also establish a Cohort Ambassador Program to invite participants across our three sites to provide continuous feedback which we will integrate into our research priorities. Our specific aims are designed to address the hypothesis that exposures to environmental chemicals that disrupt endocrine and other systems during this important life phase predispose women and children to cancer, as identified via intermediate cancer risk biomarkers. Our environmental exposures will focus on two major components: Consumer product related chemicals (including per- and polyfluoroalkyl substances [PFAS], phthalates and plasticizers, phenolic compounds, pesticides, and aromatic amines) measured via biomonitoring and prioritized based on widespread public exposure; and environmental pollutants in air and water, evaluated via geographic information system analyses of participants’ residential histories. Our outcomes will focus on biomarkers of risk for future cancer incidence including: short-term outcomes focusing on associations with key characteristics that are intermediate cancer risk biomarkers (immune response and chronic inflammation, oxidative stress and DNA damage, hormone disruption/receptor mediated effects, and cell immortalization). For longer term outcomes we will link cohort participants to California’s statewide population-based cancer registry, hospital discharge data, vital records, and Medi-Cal files in later years of the project to identify diagnoses of cancer and related conditions. Our multidisciplinary collaboration is built on our extensive knowledge and experience conducting large-scale research on environmental exposures during pregnancy and environmental risk factors for cancer. Our proposed cohort development and research plan will advance our understanding of multiple pollutant exposures in a young geographically and demographically diverse cohort, thus substantially advancing our knowledge on enhanced susceptibility to carcinogens linked to specific outcomes during these critical and understudied periods, combined with a platform that will allow flexibility and future collaboration to enhance our study as new science emerges.