Animal Models & Histology Core

项目摘要 氧化还原生物学和心血管疾病中心的目标是改善青少年的基础设施 和高级调查人员，并为初级教员提供指导，使他们变得更 竞争独立的国立卫生研究院的资金。由Karen Stokes博士领导的动物模型和组织学核心B将 为Cobre成员和我们研究所以及附近我们的研究所的其他人提供服务 心血管研究人员也有合作。休·普莱斯博士将领导组织学和基因分型 子核。这将建立在现有服务的基础上，以提供与心血管相关的病理分析和 新增一项基因分型服务。由沈布言博士领导的心血管表型分型亚核心将 提供描述疾病模型的能力。具体地说，Perimed PSI系统将提供 Visualsonics Vevo 3100超高频非侵入性成像和测量血流的能力 超声波将允许研究心脏功能，TSE遥测系统将被用来连续记录 血压、活跃度、体温和生物量。专职研究技术人员将提供服务 或培训实验室人员使用现有技术进行实验。这个核心将会有帮助 动物模型的生成，并提供尖端的表型和病理分析，以最大限度地提高 我们初级教员在心血管氧化还原调节领域未来资金方面的竞争力 疾病。

Project Abstract The goal of the Center for Redox Biology and Cardiovascular Disease is to improve the infrastructure for junior and senior investigators and to provide mentoring for the junior faculty members so that they become more competitive for independent NIH funding. The Animal Models & Histology Core B, led by Dr Karen Stokes, will provide services to both the COBRE members and others at our institute and nearby institutes at which our cardiovascular researchers have collaborations. Dr Hugh Price will lead the Histology and Genotyping Subcore. This will build upon current existing services to provide cardiovascular-related pathology analysis and add a new genotyping service. The Cardiovascular Phenotyping Subcore, led by Dr Shenu Bhuiyan, will provide capabilities to characterize the disease models. Specifically, a Peri-med PSI system will provide the ability to non-invasively image and measure blood flow, a VisualSonics Vevo 3100 Ultra High Frequency Ultrasound will allow study of cardiac function, and a TSE telemetry system will be used to continuously record blood pressure, activity, temperature, and biopotentials. Full-time research technicians will provide the services or train the lab personnel to perform their experiments using the available technologies. This core will help animal models generation, and provide cutting edge phenotypic and pathological analysis to maximize the competitiveness of our junior faculty for future funding in the area of redox regulation of cardiovascular disease.