Administrative Core

为了实现其目标，P01显著影响催产素领域进展的关键障碍， 作为一种治疗受伤后疼痛的疾病缓解剂，它需要强大的组织和凝聚力。的 行政核心将通过以下方式协调3个机构9名研究者的P01活动： 与P01领导结构的互动。行政核心的使命是促进和确保 在整个P01中应用高质量标准，以跟踪进度并为 资源分配，并提供解决问题和确保融合的机制。我们将应用 创新的方法，包括先验实验设计，假设和数据的文件 所有临床前项目的分析，类似于临床领域的试验注册，REDCap的应用 数据库，以便及时、自动地报告进展情况，以及 应用新创建的StatReviewer变体，在提交前扫描手稿， 透明的报告要求。行政核心将服务于以下主要目标 和功能： 目标1：促进日常活动、内部质量控制和进度审查 行政核心将协调资源共享，包括主要设备，畜牧业， 疼痛机制实验室内的外科设施。它将为所有临床前研究建立一个REDCap数据库， 和临床活动，并生成每月自动报告。最后，它将建立相当于审判 临床前研究注册。 目标2：确定和满足改变方针或解决冲突的需要 行政核心将提供资源和结构，以便就两个主要领域作出决策。 路线修正的原因-技术/解释障碍和来自内部的新知识， 在P01之外，通过审查自动报告和定期会议，对新的 出版物以及咨询和科学研讨会。行政核心将协调 预防和解决冲突的领导结构。 目标3：协调传播P01独特发展的概念 行政核心将通过以下方式促进P01提供的协同作用的整合和影响 定期讨论出版和介绍战略，并对这些产品进行内部审查 包括扫描透明报告要求。它还将协调介绍 向外部咨询委员会提供P01研究和进展的信息，并组织年度研讨会。

For this P01 to fulfill its goal to significantly impact critical barriers to progress in the field of oxytocin as a disease-modifying agent for pain after injury, it needs strong organization and cohesiveness. The Administrative Core will coordinate the activities of the P01 among 9 investigators across 3 institutions through interaction with the P01 leadership structure. The mission of the Administrative Core is to facilitate and assure the application of high-quality standards throughout the P01, to track progress and provide a structure for resource allocation, and to provide a mechanism for resolving problems and assuring integration. We will apply innovative approaches, including documentation of a priori experimental design, assumptions, and data analysis for all preclinical Projects, akin to trial registration in the clinical realm, application of REDCap databases to all preclinical and clinical Projects to allow timely, automated reporting of progress, and application of a newly created variant of StatReviewer to scan manuscripts prior to submission for key elements of transparent reporting requirements. The Administrative Core will serve the following primary aims and functions: Aim 1: Facilitate day to day activities, internal quality control, and review of progress The Administrative Core will coordinate resource sharing, including major equipment, animal husbandry, and surgical facilities within the Pain Mechanisms Laboratory. It will establish a REDCap database for all preclinical and clinical activities and generate monthly automated reports. Finally, it will establish the equivalent of trial registration for preclinical studies. Aim 2: Identify and address needs for changes in course or conflict resolution The Administrative Core will provide resources and structure for decision making regarding the two main reasons for course correction – technical / interpretation stumbling blocks and new knowledge from inside or outside the P01, through review of automated reports and regular meetings, an interactive review of new publications, and advisory and scientific symposia. The Administrative Core will coordinate meetings of the P01 leadership structure to prevent and resolve conflicts. Aim 3: Coordinate dissemination of concepts developed uniquely by the P01 The Administrative Core will facilitate integration and impact of the synergy provided by the P01 through regular discussions of publication and presentation strategies and through internal review of these products prior to release, including scanning for transparent reporting requirements. It will also coordinate presentation of P01 research and progress to the External Advisory Committee and organize an annual symposium.