Core B: Administrative Core

项目摘要 该计划汇集了来自马里兰州贝勒医学院安德森癌症的多学科团队 中心、约翰霍普金斯布隆伯格公共卫生学院、德克萨斯A&M大学和赖斯大学， 检查影响小鼠中克隆造血向血液恶性肿瘤进展的因素， 人类为推动这项大胆的工作，核心B（行政核心）将协调 程序.该核心将（1）通过每月组织一次 科学会议，包括所有计划参与者和计划领导的季度会议。核心 将促成一次包括所有与会者和内部及外部咨询委员会成员的年度会议， 讨论进展并生成反馈。此外，核心将确保将工作传达给 通过演讲、出版物和数据发布，及时向科学界提供信息。(2)芯会 负责健全的财务管理，包括预算和资金分配。(3)芯会 通过内部和外部咨询委员会协调正在进行的计划评估，并将利用 咨询反馈，以根据需要调整计划。(4)核心将负责确保 符合动物和IRB方案批准和药物非临床研究质量管理规范方面的伦理考虑 实践核心委员会将确保所有参与研究的研究者接受适当的最新伦理培训。 核心还将通过确保所有计划人员的培训和严格的审查来监督研究的严格性。 该中心还将负责对项目计划进行统计评估。总体而言，核心B将促进 在整个计划中实现最高水平的生产力，使每个项目和核心能够协同工作， 实现我们的总体目标，了解如何修改压力导致扩张和恶性 克隆性造血患者的转化。

Project Summary This Program brings together a multidisciplinary team from Baylor College of Medicine, MD Anderson Cancer Center, Johns Hopkins Bloomberg School of Public Health, Texas A&M University, and Rice University to examine factors influencing the progression of clonal hematopoiesis to hematologic malignancy in mice and humans. To facilitate this bold undertaking, Core B (the Administrative Core) will coordinate the activities of the Program. This Core will (1) facilitate communication within and outside the Program by organizing monthly scientific meetings including all Program participants and quarterly meetings of Program leadership. The Core will facilitate an annual meeting including all participants and internal and external advisory board members to discuss progress and generate feedback. In addition, the Core will ensure that work is communicated to the scientific community in a timely fashion through presentations, publications, and data release. (2) The Core will be responsible for sound fiscal management including budgeting and distribution of funds. (3) The Core will coordinate ongoing evaluation of the Program through internal and external advisory boards and will use the advisory feedback to adjust the Program plans as needed. (4) The Core will be responsible for ensuring compliance with ethical considerations with regard to animal and IRB protocol approvals and good laboratory practices. The Core will ensure that all participating investigators have appropriate and current ethics training. The Core will also oversee research rigor by ensuring training of all Program personnel and rigorous review. This Core will also be responsible for statistical evaluation of plans in the Projects. Overall, Core B will facilitate the highest level of productivity throughout the Program, allowing each Project and Core to work together to achieve our overall goal of understanding how modifiable stressors cause expansion and malignant transformation in patients with clonal hematopoiesis.