Core B: Administrative Core

核心 B：行政核心

• 批准号: 10332338
• 负责人: MARGARET A. GOODELL
• 金额: $ 10.68万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-08 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10332338
• 关键词: Animals; Annual Reports; Bioinformatics; Budgets; Cancer Center; Cells; Communication; Communities; Data; Ensure; Ethics; Evaluation; Experimental Designs; Feedback; Funding; Goals; Hematologic Neoplasms; Hematopoiesis; Human; Human Resources; Institution; Institutional Review Boards; Leadership; Malignant - descriptor; Manuscripts; Medicine; Monitor; Mus; Participant; Patients; Productivity; Program Evaluation; Program Reviews; Protocols documentation; Public Health Schools; Publications; Reporting; Reproducibility; Research; Research Personnel; Rice; Running; Suggestion; Texas; Time; Training; Universities; Videoconferencing; Work; cohesion; college; good laboratory practice; high standard; meetings; member; multidisciplinary; programs; sound; stressor

Project Summary This Program brings together a multidisciplinary team from Baylor College of Medicine, MD Anderson Cancer Center, Johns Hopkins Bloomberg School of Public Health, Texas A&M University, and Rice University to examine factors influencing the progression of clonal hematopoiesis to hematologic malignancy in mice and humans. To facilitate this bold undertaking, Core B (the Administrative Core) will coordinate the activities of the Program. This Core will (1) facilitate communication within and outside the Program by organizing monthly scientific meetings including all Program participants and quarterly meetings of Program leadership. The Core will facilitate an annual meeting including all participants and internal and external advisory board members to discuss progress and generate feedback. In addition, the Core will ensure that work is communicated to the scientific community in a timely fashion through presentations, publications, and data release. (2) The Core will be responsible for sound fiscal management including budgeting and distribution of funds. (3) The Core will coordinate ongoing evaluation of the Program through internal and external advisory boards and will use the advisory feedback to adjust the Program plans as needed. (4) The Core will be responsible for ensuring compliance with ethical considerations with regard to animal and IRB protocol approvals and good laboratory practices. The Core will ensure that all participating investigators have appropriate and current ethics training. The Core will also oversee research rigor by ensuring training of all Program personnel and rigorous review. This Core will also be responsible for statistical evaluation of plans in the Projects. Overall, Core B will facilitate the highest level of productivity throughout the Program, allowing each Project and Core to work together to achieve our overall goal of understanding how modifiable stressors cause expansion and malignant transformation in patients with clonal hematopoiesis.

项目摘要 该计划汇集了来自马里兰州贝勒医学院的多学科团队 中心，约翰·霍普金斯彭博公共卫生学院，德克萨斯农工大学和赖斯大学 检查影响小鼠和小鼠血液学恶性肿瘤进展的因素 人类。为了促进这项大胆的事业，核心B（行政核心）将协调 程序。该核心将（1）通过组织每月通过 科学会议，包括所有计划参与者和计划领导的季度会议。核心 将促进包括所有参与者以及内部和外部咨询委员会成员在内的年度会议 讨论进度并产生反馈。此外，核心将确保将工作传达给 科学界通过演讲，出版物和数据发布及时进行。 （2）核心将 负责合理的财政管理，包括预算和资金分配。 （3）核心将 通过内部和外部咨询委员会协调对计划的持续评估，并将使用 咨询反馈根据需要调整计划计划。 （4）核心将负责确保 符合关于动物和IRB协议批准和良好实验室的道德考虑因素 实践。核心将确保所有参与的调查人员都有适当和当前的道德培训。 核心还将通过确保对所有计划人员进行培训和严格的审查来监督研究严格。 该核心还将负责项目中计划的统计评估。总体而言，核心B将有助于 整个计划中的最高生产率水平，使每个项目和核心都可以共同努力 实现我们了解可修改压力源如何引起扩展和恶性的总体目标 克隆造血的患者转化。