Core B: Administrative Core

项目摘要 该项目汇集了来自马里兰州安德森癌症贝勒医学院的一个多学科团队 中心、约翰霍普金斯大学布隆伯格公共卫生学院、德克萨斯农工大学和莱斯大学 检测小鼠克隆性造血向恶性血液病发展的影响因素 人类。为促进这项大胆的工作，核心B(行政核心)将协调 程序。该核心将(1)通过每月组织一次，促进计划内外的沟通 包括所有计划参与者的科学会议和计划领导的季度会议。《核心》 将推动召开年度会议，包括所有与会者以及内部和外部咨询委员会成员，以 讨论进度并产生反馈。此外，核心将确保将工作传达给 通过演示、出版物和数据发布，及时向科学界提供信息。(2)核心将 负责健全的财务管理，包括预算和资金分配。(3)核心将 通过内部和外部咨询委员会协调对该计划的持续评估，并将使用 根据需要提供咨询反馈，以调整计划计划。(4)核心将负责确保 遵守关于动物和IRB方案批准和良好实验室的伦理考虑 练习。该核心将确保所有参与调查的调查员都接受了适当和最新的道德操守培训。 该核心还将通过确保对所有计划人员的培训和严格审查来监督研究的严格性。 该核心还将负责项目中计划的统计评估。总体而言，核心B将促进 在整个计划中实现最高水平的工作效率，使每个项目和核心能够协同工作 实现我们的总体目标，即了解可更改的压力源是如何导致扩张和恶性的 克隆性造血患者的转化。

Project Summary This Program brings together a multidisciplinary team from Baylor College of Medicine, MD Anderson Cancer Center, Johns Hopkins Bloomberg School of Public Health, Texas A&M University, and Rice University to examine factors influencing the progression of clonal hematopoiesis to hematologic malignancy in mice and humans. To facilitate this bold undertaking, Core B (the Administrative Core) will coordinate the activities of the Program. This Core will (1) facilitate communication within and outside the Program by organizing monthly scientific meetings including all Program participants and quarterly meetings of Program leadership. The Core will facilitate an annual meeting including all participants and internal and external advisory board members to discuss progress and generate feedback. In addition, the Core will ensure that work is communicated to the scientific community in a timely fashion through presentations, publications, and data release. (2) The Core will be responsible for sound fiscal management including budgeting and distribution of funds. (3) The Core will coordinate ongoing evaluation of the Program through internal and external advisory boards and will use the advisory feedback to adjust the Program plans as needed. (4) The Core will be responsible for ensuring compliance with ethical considerations with regard to animal and IRB protocol approvals and good laboratory practices. The Core will ensure that all participating investigators have appropriate and current ethics training. The Core will also oversee research rigor by ensuring training of all Program personnel and rigorous review. This Core will also be responsible for statistical evaluation of plans in the Projects. Overall, Core B will facilitate the highest level of productivity throughout the Program, allowing each Project and Core to work together to achieve our overall goal of understanding how modifiable stressors cause expansion and malignant transformation in patients with clonal hematopoiesis.