Translational Core

项目摘要/摘要-翻译核心 我们建议成立生物医学卓越研究中心(COBRE)进行药物研究 肯塔基大学(英国)的创新与研究。CPRI将作为一个综合性的多学科中心 侧重于翻译化学生物学[化学生物学的纽带(化学生物学的应用 开发有效的探针/模型以促进我们对生物学的理解的原则)和药学 科学(将药学原理应用于解决未满足的问题的先进引线/材料/装置 临床需求)]。科布雷将利用和开发独特的翻译化学生物学研究支持 基础设施/专业知识，以促进初级教师指导和职业发展，创新的生物医学 研究探索/工具/模型/材料的开发和验证，以及潜力的早期进展 “可转换”资产。在此背景下，CPRI翻译核心将提供关键的基础设施和专业知识 支持以探测/铅/材料发现为中心的实验研究。在马科斯博士的共同指导下 Leggas和Jon Thorson，核心将支持化验设计、开发、验证和实施；试点 筛选活动；一套体外吸收、分布、代谢、排泄和毒性(ADMET) 首先是在动物肾上腺素/药代动力学(PK)研究中。核心支持将针对以下目标量身定做 具体的Cobre项目/试点需求和筛选服务也将利用CPRI独有的化合物 收藏品(包括天然产品和合成产品)。核心的服务经过战略设计，旨在 整合和补充CPRI计算核心和附属于CPRI的支持 分子医学有机合成核心科布雷。总体而言，CPRI相应的完全整合 研究支持能力和专业知识将加速创新的、可翻译的跨学科研究 并促进初级调查员的职业发展。

PROJECT SUMMARY/ABSTRACT – TRANSLATIONAL CORE We propose to establish a Center of Biomedical Research Excellence (COBRE) in Pharmaceutical Research and Innovation at the University of Kentucky (UK). CPRI will serve as a comprehensive multidisciplinary center focused on translational chemical biology [the nexus of chemical biology (the application of chemical biology principles to develop validated probe/models to advance our understanding of biology) and pharmaceutical science (the application of pharmaceutical principles to advance leads/materials/devices that address unmet clinical needs)]. The COBRE will leverage and develop unique translational chemical biology research support infrastructure/expertise to facilitate junior faculty mentorship and career development, innovative biomedical research probe/tool/model/materials development and validation, and the early advancement of potential ‘translatable’ assets. Within this context, the CPRI Translational Core will provide key infrastructure and expertise to support experimental studies central to probe/lead/materials discovery. Under the co-direction of Drs. Markos Leggas and Jon Thorson, the Core will support assay design, development, validation and implementation; pilot screening campaigns; a suite of in vitro absorption, distribution, metabolism, excretion and toxicity (ADMET) assays; and first in animal ADMET/pharmacokinetics (PK) studies. Support in the Core will be tailored toward specific COBRE project/pilot needs and screening services will also leverage CPRI-exclusive compound collections (both natural products and synthetics). The Core’s services have been strategically designed to integrate with, and complement, the support provided by the CPRI Computational Core and the CPRI-affiliated COBRE for Molecular Medicine Organic Synthesis Core. Together, CPRI’s corresponding fully integrated research support capabilities and expertise will accelerate innovative, ‘translatable’ transdisciplinary research and facilitate junior investigator career development.