Screening, Prevention, Etiology, and Cancer Survivorship

筛查、预防、病因学和癌症生存计划摘要 SPECS计划的目标是解决癌症控制的广泛领域，包括病因学， 预防、早期发现、治疗和生存。SPECS计划的具体目标是1) 通过确定风险因素和开发新产品和公共政策来预防癌症 暴露，2)早期发现癌症，了解诊断和治疗的风险和好处 选项，以及3)确定影响癌症幸存者预后和生活质量的因素。规格说明 该项目由安妮·约瑟夫，医学硕士，公共卫生硕士，希瑟·纳尔逊，公共卫生硕士，博士和凯伦·昆茨，SCD领导，拥有49 成员，代表18个系、8所学校或学院和4个外部组织。最后一次 预算年度，这些成员得到了国家统计局230万美元的直接研究资金的支持 癌症研究所；所有赞助来源的资助总额为800万美元的直接研究资金。自.以来 2013年，计划成员发表了1564篇论文(6%发表在影响较大的期刊上)，其中20%的结果是 来自计划内协作，12%来自计划间协作，85%来自外部 合作。自2013年以来，所有临床研究类别的185项临床试验都是在这一框架下开始的 在方案领域，已经积累了13,122个主题。共济会癌症中心提供了大量的 对该计划的价值，包括获得共享资源、投资招聘新教师 成员，资助21个试点项目，总额超过500,000美元，以及5个研究务虚会。SPECS计划 研究范围涵盖癌症的各个领域，包括病因学、预防、早期发现、 诊断、治疗和生存。交叉主题包括沟通、健康差距、健康 推广、生物标志物、流行病学、决策建模和成本效益分析以及公共政策。 SPECS研究针对明尼苏达州不同人群的癌症负担，包括 新移民、美洲原住民和其他弱势群体的需求。SPECS研究人员有特殊的 重点关注宫颈癌、结肠癌、肺癌和前列腺癌，反映我们人口的发病率。 SPECS调查人员出色地利用共济会癌症中心的共享资源，特别是Analytical 生物化学、生物统计学和临床信息学。有一个活跃的培训部分，包括T32 癌症与健康差异、儿科癌症流行病学和卫生服务研究。直接指定规格 解决了几个科学增长优先事项(SPG)，包括SPG4-使用生物标记物进行个性化 癌症预防，SPG5--建立一个新的明尼苏达州队列，SPG6--开发有效的方法 提高弱势人群对循证癌症预防行为的接受程度 明尼苏达州不成比例的癌症负担。

Screening, Prevention, Etiology, and Cancer Survivorship Program Summary The goal of the SPECS Program is to address the broad spectrum of cancer control, including etiology, prevention, early detection, treatment, and survivorship. The specific aims of the SPECS Program are to 1) prevent cancer by identifying risk factors and developing novel products and public policies to reduce exposure, 2) detect cancer at an early stage and understand the risks and benefits of diagnosis and treatment options, and 3) identify factors that impact prognosis and quality of life among cancer survivors. The SPECS Program is led by Anne Joseph, MD, MPH; Heather Nelson, MPH, PhD; and Karen Kuntz, ScD and has 49 members, representing 18 departments, 8 schools or colleges, and 4 external organizations. For the last budget year, these members were supported by $2.3 million in direct research funding from the National Cancer Institute; support from all sponsored sources totaled $8.0 million in direct research funding. Since 2013, Program members have published 1564 papers (6% in high-impact journals), 20% of which resulted from intraprogrammatic collaborations, 12% from interprogrammatic collaborations, and 85% from external collaborations. Since 2013, 185 clinical trials in all clinical research categories have opened under this programmatic area and have accrued 13,122 subjects. The Masonic Cancer Center has provided substantial value to the program, including access to shared resources, investment in the recruitment of a new faculty member, funding of 21 pilot projects totaling over $500,000, and 5 research retreats. The SPECS Program research portfolio spans the cancer continuum, including the study of etiology, prevention, early detection, diagnosis, treatment, and survivorship. Crosscutting themes include communication, health disparities, health promotion, biomarkers, epidemiology, decision modeling and cost-effectiveness analysis, and public policy. SPECS research is directed at the cancer burdens of the diverse populations of Minnesota, including the needs of new immigrant, Native American, and other vulnerable populations. SPECS researcher has particular focus on cervical, colon, lung, and prostate cancers, mirroring the disease incidences of our populations. SPECS investigators make excellent use of Masonic Cancer Center Shared Resources, especially Analytical Biochemistry, Biostatistics, and Clinical Informatics. There is an active training component, including T32s on cancer and health disparities, pediatric cancer epidemiology, and health services research. SPECS directly addresses several Scientific Priorities for Growth (SPG) including, SPG4 – use biomarkers to individualize cancer prevention, SPG5 – Establish a new Minnesota-based cohort, and SPG6 – Develop effective methods to increase adoption of evidence-based cancer prevention behaviors by vulnerable populations with disproportionate cancer burden in Minnesota.