Shared Resource 05: Clinical Treatment Unit/ Clinical Trials Processing Lab (CTU/CTPL-SR)

共享资源 05：临床治疗室/临床试验处理实验室 (CTU/CTPL-SR)

• 批准号: 10333293
• 负责人: GREGORY A OTTERSON
• 金额: $ 17.94万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-12 至 2025-11-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10333293
• 关键词: Abbreviations; Address; Air; Ambulatory Care; Appointment; Basic Science; Biological; Biomedical Research; Biometry; Brain; Budgets; Cancer Biology; Cancer Center; Cancer Center Support Grant; Cancer Control; Cancer Hospital; Chemoprevention; Chest; Clinical; Clinical Research; Clinical Treatment; Clinical Trials; Clinical Trials Network; Clinical Trials Unit; Collection; Comparative Pathology; Complex; Comprehensive Cancer Center; Consultations; Dangerousness; Development; Disease; Drug Kinetics; Enrollment; Floor; Flow Cytometry; Funding; Genomics; Grant; Growth; Gynecologic Oncology; Hematology; Hospitals; Human; Immunologic Monitoring; Immunooncology; Institutes; International; Intervention; Intramural Research Program; Investigational Therapies; Laboratories; Location; Malignant Neoplasms; Medical Oncology; Microscopy; Mission; Molecular Carcinogenesis; Monitor; NCI Center for Cancer Research; Nutrient; Ohio; Patients; Pediatric Hospitals; Pharmaceutical Chemistry; Pharmacodynamics; Pharmacogenomics; Phase; Phytochemical; Play; Proteomics; Protocols documentation; Publications; Research; Research Institute; Research Personnel; Resource Sharing; Retirement; Role; Sampling; Services; Shipping; Site; Specimen; Specimen Handling; Surveys; System; Translational Research; Transportation; United States Food and Drug Administration; Universities; Validation; Vertebral column; Visit; animal imaging; biomedical informatics; cancer therapy; cost effective; design; digital imaging; drug development; early phase clinical trial; expectation; first-in-human; improved; investigator-initiated trial; leukemia; leukemia tissue bank; malignant breast neoplasm; meetings; member; oncology service; pathology imaging; programs; recruit; sample collection; translational clinical trial; translational genomics; translational therapeutics

PROJECT SUMMARY – CLINICAL TREATMENT UNIT (CTU) AND CLINICAL TRIALS PROCESSING LABORATORY (CTPL) SHARED RESOURCE (CTU/CTPL-SR) An important scientific mission of the OSUCCC is to conduct high quality, cutting edge clinical research for the improved understanding and advancement in treatments of human malignancies. The CTU/CTPL-SR is composed of two different, but intimately related units, namely the Clinical Treatment Unit (CTU) and the Clinical Trials Processing Laboratory (CTPL). The CCSG will only support the CTPL component of the shared resource; support of the CTU component will be entirely from OSUCCC institutional funding, as has been the case for the last two CCSG cycles. The CTU/STPL-SR manages all clinical trial biospecimen collection and processing for samples that are sent externally, and for most clinical trials where samples are being sent to OSUCCC investigator laboratories or shared resources. Key services, in support of all clinical trials needing biospecimen collection, processing and shipping for the CTU/CTPL-SR include consultation on protocol design with regard to correlative specimens, procurement and processing of correlative specimens per protocol specifications developing protocol in-service materials, participating in site initiation visits and protocol implementation meetings, assisting in monitoring visits and audits and shipping specimens internal or external to OSU for analysis. The CTU/CTPL-SR coordinates with other shared resources and departments to address the wide array of biological specimens required for current clinical trials. The Specific Aims are to: 1) provide a stable, reliable, and cost-effective, state-of-the art unit for conducting early phase clinical trials requiring intense monitoring and/or complex correlative specimen collection; and, 2) provide high-quality, high-volume specimen processing, short-term storage and distribution of biospecimens collected as correlative components of phase I, II and III translational clinical trials. During the current grant period, the CTU/CTP-SR has supported 129 investigators (60% OSUCCC members) from all five OSUCCC research programs, and procured a total of 104,831 specimens from patients enrolled in 729 clinical trials. Also, the CTU/CTPL-SR contributed to 102 publications (36 > 10 impact factor). The CTU/CTPL-SR will continue to be an essential shared resource to facilitate high-quality translational research within the OSUCCC, especially given the current growth plans that include: a) recruitment for both immuno-oncology (Pelotonia Institute of Immuno-Oncology) and translational genomics; and b) commitments to medical oncology, hematology and gynecologic oncology for recruitments and corresponding expectations for increased INDs and trial accruals. The annual budget of the CTU-CTPL-SR is $1,104,344, yet the CCSG request is $126,251. As such, the CTU/CTPL-SR leverages extensive institutional support and seeks only 11.4% support from CCSG funds.

项目总结-临床治疗单元（ctu）和临床试验处理