Interdisciplinary Program in Microbe-Host Biology

项目摘要/摘要 今天的现实包括来自新出现的微生物疾病的威胁，不断上升的机会性感染，发展 多药耐药微生物的存在，以及现有疫苗因微生物进化而失效。这些威胁 人类健康需要为下一代科学家提供全面的跨学科培训计划 在微生物-宿主界面和新兴方法学的研究中。该培训计划的中心将是 俄亥俄州立大学传染病研究所(IDI)专注于宿主病原体研究， 教育和外展。IDI带来了一个充满活力和活力的社区，促进了 解决传染病关键问题的方法。培训计划的所有指导者都是 IDI的成员，代表了宿主-病原体相互作用方面的大量专业知识。两个PD(MPD 机构)拥有强大的研究计划和致力于培训和教育的职业。因此，PDS 代表一个优秀、成熟和协作的团队来监督这一广泛的创新计划 强调：1)高度互动的科学社区，2)多学科的科学方法，3)沉浸其中 在大型学术健康科学中心的生物医学研究社区的学员，4)整合 临床和基础科学，5)接触有经验和有才华的科学家教育者和导师，以及 6)为学员增加了几个优势，包括充满活力的外部培训计划。主要的主题领域是 1)病毒病原体，2)宿主防御，3)微生物群落。这些主题领域代表了五个领域中的三个 IDI跨学科方案领域，我们从每个领域挑选了最敬业的成员 作为这台T32的教官。该计划将包括一个遴选和监督委员会，一个杰出的 并聘请外部咨询委员会，IDI内部必要的行政结构，以执行 计划，以及一支高素质的实习生队伍。重点是在受训人员中招募多样性，并在 对负责任的研究行为的正式指导。我们要求3名博士后和2名博士后学者 每年的老虎机。拟议的培训体验包括最先进的课程、敬业的教职员工、 卓越的资源，接触到多样化的职业道路，以及导师和网络与持续的 机构支持将使受训人员为不断变化的生物医学劳动力格局做好准备

PROJECT SUMMARY/ABSTRACT Today's reality includes threats from emergent microbial diseases, rising opportunistic infections, development of multi-drug resistant microbes, and inefficacy of existing vaccines due to microbial evolution. These threats to human health necessitate comprehensive interdisciplinary training programs for the next generation of scientists in studies of the microbe-host interface and emerging methodologies. The hub for this training program will be The Ohio State University Infectious Disease Institute (IDI), which is focused on Host-Pathogen Research, Education, and Outreach. IDI brings together a vibrant and dynamic community that fosters a collaborative approach to address critical problems in infectious disease. All the preceptors for the training program are members of IDI and represent a vast array of expertise in host-pathogen interactions. Both PDs (MPD mechanism) have strong research programs and careers dedicated to training and education. Thus the PDs represent an outstanding, established and collaborative team to oversee this broad innovative program which emphasizes: 1) a highly interactive scientific community, 2) a multidisciplinary approach to science, 3) immersion of trainees in the biomedical research community of a large academic health sciences center, 4) integration of the clinical and basic sciences, 5) exposure to experienced and talented scientist educators and mentors, and 6) several added advantages to trainees, including a vibrant externship program. The major thematic areas are 1) Viral pathogens, 2) Host defense, and 3) Microbial communities. These thematic areas represent three of five IDI interdisciplinary programmatic areas and we have selected the most dedicated members from each area to serve as preceptors for this T32. The program will include a Selection and Oversight Committee, an outstanding and engaged External Advisory Committee, the necessary administrative structure within IDI to execute the program, and a high-quality trainee pool. Emphasis is placed on the recruitment of diversity in trainees and on formal instruction for the responsible conduct of research. We request 3 pre-doctoral, and 2 post-doctoral scholar slots per year. The proposed training experience includes a state-of-the-art curriculum, dedicated faculty, exceptional resources, exposure to diverse career paths, and mentors and networking combined with sustained institutional support that will prepare the trainees for the evolving landscape of our biomedical workforce