The role of depression in cognitive decline of oldest-old African Americans

抑郁症在最年长的非裔美国人认知能力下降中的作用

• 批准号: 10334333
• 负责人: Elizabeth Guerrero-Berroa
• 金额: $ 10.49万
• 依托单位: HERBERT H. LEHMAN COLLEGE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-05-15 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10334333
• 关键词: Address; Affect; African American population; Age; Age-Years; Alzheimer' s Disease; American; Awareness; Biological; Biological Markers; Chronic; Cognition; Communities; Data; Dementia; Depressed mood; Development; Diagnosis; Elderly; Enrollment; Equipment and supply inventories; Ethnic group; Etiology; Health Personnel; Hispanic Populations; Impaired cognition; Individual; Inflammation; Inflammatory; Investigation; Knowledge; Lead; Measures; Mediator of activation protein; Mental Depression; Minority Groups; Neuropsychology; Population; Predisposition; Prevalence; Process; Questionnaires; Research; Risk; Risk Factors; Role; Sampling; Serum; Target Populations; Testing; Time; Vulnerable Populations; base; clinical practice; cognitive function; cytokine; dementia risk; depressive symptoms; diabetic; effective therapy; geriatric depression; high risk; high risk population; improved; inflammatory marker; insight; neuropsychiatry; non-demented; normal aging; prevent; racial and ethnic; social stigma; targeted treatment

PROJECT SUMMARY/ABSTRACT Older adults (85 and older), the fastest growing segment of the population, are at very high risk of dementia. Some minority groups, such as African Americans, are at higher risk of dementia compared to Whites. However, little is known about the risk factors that might be involved in their high susceptibility to dementia. Depression, one of the most frequent and debilitating psychiatric conditions in older adults, has been consistently associated with cognitive decline in Whites. Although depression in African Americans is more chronic and untreated, compared with Whites, only a handful of studies have investigated the relationship between depression and cognitive decline in this racial/ethnic group. To our knowledge, this relationship has not been examined in oldest-old (≥80) African Americans. Chronic inflammation is also associated with both depression and cognitive decline. Because depression and inflammation are treatable conditions, better understanding of their role in cognition may lead to reduced dementia risk in this very high risk, growing, and understudied population. This study will examine the inter-relationships of depression and inflammation with change in cognition over time in 192 non-demented community-dwelling oldest-old African Americans. We will examine the following three Specific Aims: Aim 1: To examine the association between depression measures and cognitive decline over time. We hypothesize that: a) Depression is related to a greater rate of cognitive decline. b) Based on compelling preliminary data, apathy is the depression measure hypothesized to be most strongly related to a greater rate of cognitive decline. Aim 2: To examine the association between baseline inflammation and cognitive decline. We hypothesize that higher levels of inflammatory cytokines at baseline are related to a greater rate of cognitive decline. Aim 3: To examine the inter-relationships of depression, inflammation and cognitive decline. a) We hypothesize that inflammation serves as a moderator in the relationship between depression and cognitive decline in oldest-old African Americans. If significant results are generated, they can lead to increasing public awareness about the importance of timely depression diagnosis and development of mechanism-based effective and well-targeted treatment for the oldest-old community of African Americans, who are at particularly high-risk for dementia.

项目总结/摘要 老年人（85岁及以上）是人口中增长最快的部分，患痴呆症的风险非常高。 一些少数群体，如非洲裔美国人，与白人相比，患痴呆症的风险更高。 然而，很少有人知道的风险因素，可能涉及他们对痴呆症的高易感性。 抑郁症是老年人中最常见和最令人衰弱的精神疾病之一， 与白人认知能力下降有关尽管非裔美国人的抑郁症 与白人相比，慢性和未经治疗的，只有少数研究调查了这种关系 抑郁症和认知能力下降之间的联系据我们所知，这种关系 未在年龄最大（≥80岁）的非裔美国人中进行检查。慢性炎症也与两者有关 抑郁症和认知能力下降。因为抑郁症和炎症是可以治疗的， 了解他们在认知中的作用可能会导致降低痴呆症的风险，在这个非常高的风险，增长， 被忽视的人群 这项研究将探讨抑郁症和炎症与认知变化的相互关系， 192名非痴呆社区居住的最年长的非洲裔美国人的时间。我们将检查以下内容 三个具体目标：目标1：检查抑郁测量和认知能力下降之间的关联 随着时间我们假设：a）抑郁症与认知能力下降的速度更快有关。B）基于 令人信服的初步数据，冷漠是抑郁的措施，假设是最密切相关的， 认知能力下降的速度更快。目的2：检查基线炎症与 认知能力下降我们假设基线时较高水平的炎性细胞因子与 认知能力下降的速度更快。目的3：研究抑郁症、炎症和 认知能力下降a）我们假设炎症在以下关系中起调节作用： 抑郁症和认知能力下降。如果产生了显著的结果， 提高公众对及时诊断抑郁症的重要性的认识， 为非洲裔美国人中最年长的社区提供基于机制的有效和有针对性的治疗， 他们患痴呆症的风险特别高。