Oklahoma Center of Medical Imaging for Translational Cancer Research

俄克拉荷马州转化性癌症研究医学影像中心 抽象-整体组件 为了与俄克拉荷马大学(OU)的战略计划高度一致，以创建 多学科研究中心优秀的主要研究主题之一，即未来的 Health，这个Cobre应用程序的首要目标是建立一个新的医学成像中心 利用已建立的研究支持资源进行转化型癌症研究 俄亥俄大学生物医学工程与临床研究合作网络。这只科布雷将提供 研究基础设施以及多学科领导和指导团队，以支持有前途的 初级调查人员建立独立研究生涯时的研究项目负责人(RPL)。一个 基本组成部分将为开发和应用创新技术的创新研究项目提供支持 医学成像技术和定量成像预测标记物对转化性癌症的研究。这个 这些研究项目的成功将对未来的健康产生影响和贡献，包括 的精准医学显著提高了个性化癌症风险预测、筛查、 诊断和治疗。自2012年以来，OU开发并建立了协作网络和多样化 在加洛格利学院生物医学成像工程系之间架起桥梁的研究项目组合 与斯蒂芬森癌症中心(SCC)的内科科学家或临床研究人员一起进行工程(GCoE)。 基于我们使用医学成像技术进行联合转译癌症研究的经验， Cobre旨在支持和进一步发展GCoE之间的这种协作研究基础设施 和SCC，以加强研究能力和进展，因为他们进一步发展团队为基础的 和翻译研究项目。为了促进潜在高价值的翻译研究项目 临床影响和意义，这次Cobre将包括具有生物医学成像工程和 临床研究培训背景。每个RPL还将有两名具有生物医学专业知识的高级导师 分别加强工程和临床研究，进一步提升协作研究方式。在……里面 总结，为了提高OU和OU的医学影像相关转译癌症研究能力 确保RPL建立独立的研究生涯，我们在这方面提出了以下三个具体目标 科布雷：(1)在他们提议的研究项目中实施一个专门的计划来指导RPL，并 使他们成为独立的研究人员，得到非创意外部研究的支持；(2)加强 并开发新的研究基础设施和共享资源，以支持当前和未来的医学成像 相关的转化型癌症研究项目；(3)促进和加强多学科合作 生物医学工程学院与内科科学家或临床研究人员之间的研究活动 协助尚未完成的转化医学影像相关癌症研究项目。

Oklahoma Center of Medical Imaging for Translational Cancer Research Abstract – Overall Component In order to highly align with the Strategic Plan of the University of Oklahoma (OU) to create the multidisciplinary Research Centers of Excellent in one of the primary research themes namely, the future of health, the overarching objective of this COBRE application is to establish a new medical imaging center for conducting the translational cancer research by leveraging the established research supporting resource and collaboration network between the biomedical engineering and clinical research in OU. This COBRE will provide research infrastructure along with the multidisciplinary leadership and mentoring teams to support the promising research project leaders (RPLs) of the junior investigators as they establish independent research careers. An essential component will be providing support for innovative research projects that develop and apply novel medical imaging technology and quantitative imaging predictive markers to translational cancer research. The success of these research projects will make impact and contribution to the future of health including the advance of the precision medicine to significantly improve efficacy of the personalized cancer risk prediction, screening, diagnosis and treatment. Since 2012, OU has developed and established a collaborative network and diverse portfolio of research projects that bridge the biomedical imaging engineering faculty in the Gallogly College of Engineering (GCoE) with the physician scientists or clinical researchers in the Stephenson Cancer Center (SCC). Building on our experience in conducting joint translational cancer research using medical imaging technology, this COBRE aims to support and further develop this collaborative research infrastructure between the GCoE and SCC to enhance the research capability and progress of the RPLs as they further develop the team-based and translational research projects. In order to promote the translational research projects with potentially high clinical impact and significance, this COBRE will include the RPLs with both biomedical imaging engineering and clinical research training backgrounds. Each RPL will also have two senior mentors with expertise in biomedical engineering and clinical research, respectively, to further enhance the collaborative research approach. In summary, in order to enhance the medical imaging related translational cancer research capacity in OU and ensure RPLs to establish independent research careers, we propose the following three Specific Aims in this COBRE: (1) to implement a dedicated program for mentoring RPLs in their proposed research projects and enabling them to become independent researchers with non-IDeA external research support; (2) to strengthen and develop new research infrastructure and shared resources to support current and future medical imaging related translational cancer research projects; and (3) to foster and enhance the multidisciplinary collaborative research activities between the biomedical engineering faculty and physician scientists or clinical researchers to facilitate the outstanding translational medical imaging related cancer research projects.