Oklahoma Center of Medical Imaging for Translational Cancer Research

俄克拉荷马州转化癌症研究医学影像中心

• 批准号: 10334981
• 负责人: Bin Zheng
• 金额: $ 228.64万
• 依托单位: UNIVERSITY OF OKLAHOMA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-02-15 至 2026-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10334981
• 关键词: Address; Advanced Malignant Neoplasm; Advisory Committees; American Cancer Society; American Indians; Area; Biomedical Engineering; Cancer Burden; Cancer Center; Cancer Patient; Cancer Research Project; Centers of Research Excellence; Clinical; Clinical Data; Clinical Research; Collaborations; Communities; Data; Databases; Development; Diagnosis; Early Diagnosis; Economic Burden; Education; Engineering; Ensure; Environment; Equipment; Faculty; Fostering; Funding; Future; Goals; Health; Health Sciences; Healthcare; Image; Imaging Techniques; Imaging technology; Infrastructure; Interdisciplinary Study; Investments; Joints; Lead; Leadership; Machine Learning; Malignant Neoplasms; Medical Imaging; Medical center; Mentors; Methods; Molecular; Morphology; National Cancer Institute; Oklahoma; Physicians; Physiology; Pilot Projects; Play; Positioning Attribute; Prognosis; Public Health; Publishing; Regulation; Research; Research Activity; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Research Training; Resource Sharing; Resources; Role; Scientist; Screening for cancer; Security; Seeds; Services; Societies; Software Tools; Statistical Data Interpretation; Strategic Planning; Translational Research; Universities; Vertebrates; Water; base; biomedical imaging; cancer imaging; cancer risk; cancer therapy; career; clinical imaging; clinically relevant; cohort; college; data resource; experience; human subject; image processing; imaging biomarker; imaging facilities; imaging informatics; improved; in vivo; individual patient; innovation; mortality; multidisciplinary; novel; overtreatment; personalized medicine; precision medicine; predictive marker; programs; quantitative imaging; research study; risk prediction; screening; social; success; synergism; technology development; tool; translational cancer research; tumor diagnosis

Oklahoma Center of Medical Imaging for Translational Cancer Research Abstract – Overall Component In order to highly align with the Strategic Plan of the University of Oklahoma (OU) to create the multidisciplinary Research Centers of Excellent in one of the primary research themes namely, the future of health, the overarching objective of this COBRE application is to establish a new medical imaging center for conducting the translational cancer research by leveraging the established research supporting resource and collaboration network between the biomedical engineering and clinical research in OU. This COBRE will provide research infrastructure along with the multidisciplinary leadership and mentoring teams to support the promising research project leaders (RPLs) of the junior investigators as they establish independent research careers. An essential component will be providing support for innovative research projects that develop and apply novel medical imaging technology and quantitative imaging predictive markers to translational cancer research. The success of these research projects will make impact and contribution to the future of health including the advance of the precision medicine to significantly improve efficacy of the personalized cancer risk prediction, screening, diagnosis and treatment. Since 2012, OU has developed and established a collaborative network and diverse portfolio of research projects that bridge the biomedical imaging engineering faculty in the Gallogly College of Engineering (GCoE) with the physician scientists or clinical researchers in the Stephenson Cancer Center (SCC). Building on our experience in conducting joint translational cancer research using medical imaging technology, this COBRE aims to support and further develop this collaborative research infrastructure between the GCoE and SCC to enhance the research capability and progress of the RPLs as they further develop the team-based and translational research projects. In order to promote the translational research projects with potentially high clinical impact and significance, this COBRE will include the RPLs with both biomedical imaging engineering and clinical research training backgrounds. Each RPL will also have two senior mentors with expertise in biomedical engineering and clinical research, respectively, to further enhance the collaborative research approach. In summary, in order to enhance the medical imaging related translational cancer research capacity in OU and ensure RPLs to establish independent research careers, we propose the following three Specific Aims in this COBRE: (1) to implement a dedicated program for mentoring RPLs in their proposed research projects and enabling them to become independent researchers with non-IDeA external research support; (2) to strengthen and develop new research infrastructure and shared resources to support current and future medical imaging related translational cancer research projects; and (3) to foster and enhance the multidisciplinary collaborative research activities between the biomedical engineering faculty and physician scientists or clinical researchers to facilitate the outstanding translational medical imaging related cancer research projects.

俄克拉荷马州转化癌症研究医学影像中心 摘要-整体组件 为了与俄克拉荷马州大学（University of Oklahoma）的战略计划高度一致， 优秀的多学科研究中心的主要研究主题之一，即未来的 在健康方面，COBRE应用的首要目标是建立一个新的医学成像中心， 利用现有的研究支持资源开展转化型癌症研究， 生物医学工程和临床研究之间的合作网络。眼镜蛇将提供 研究基础设施沿着多学科的领导和指导团队，以支持有前途的 初级研究人员的研究项目负责人（RPL），因为他们建立了独立的研究生涯。一个 一个重要的组成部分将是为创新研究项目提供支持，开发和应用新的 医学成像技术和定量成像预测标记物转化为癌症研究。的 这些研究项目的成功将对未来的健康产生影响和贡献，包括促进 精准医学的应用，显著提高个性化癌症风险预测、筛查， 诊断和治疗。自2012年以来，我们开发并建立了一个合作网络， 研究项目的组合，桥梁的生物医学成像工程学院在加洛格利学院， 与斯蒂芬森癌症中心（SCC）的医生科学家或临床研究人员一起进行工程学（GCoE）。 基于我们在利用医学成像技术进行联合转化癌症研究方面的经验， 该COBRE旨在支持和进一步发展全球卓越中心之间的合作研究基础设施 和SCC，以提高研究能力和进步的RPL，因为他们进一步发展以团队为基础的 和翻译研究项目。为了促进具有潜在高价值的转化研究项目， 临床影响和意义，这个COBRE将包括具有生物医学成像工程和 临床研究培训背景。每个RPL还将有两名具有生物医学专业知识的高级导师 工程和临床研究，以进一步加强合作研究的方法。在 为了提高中国医学影像学相关转化肿瘤研究能力， 为确保研究授权书建立独立的研究事业，我们提出以下三个具体目标， COBRE：（1）实施一个专门的计划，在他们提出的研究项目中指导RPL， 使他们能够在非IDEA外部研究支持下成为独立研究人员;（2）加强 开发新的研究基础设施和共享资源，以支持当前和未来的医学成像 相关的转化癌症研究项目;以及（3）促进和加强多学科合作 生物医学工程学院和医生科学家或临床研究人员之间的研究活动， 促进优秀的转化医学影像相关的癌症研究项目。