Core B: Physics-Dosimetry Core

核心 B：物理剂量测定核心

• 批准号: 10333803
• 负责人: Eric Stanton Diffenderfer
• 金额: $ 23.19万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-02-15 至 2027-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10333803
• 关键词: 3D Print; Abdomen; Aftercare; Animal Model; Animals; Area; Biological Models; Calibration; Canis familiaris; Carbon; Cell Survival; Collimator; Consult; Custom; Dose; Dose-Rate; Electrons; Ensure; Equipment; Experimental Neoplasms; Goals; Infrastructure; Institution; International; Leg; Linear Energy Transfer; Measurement; Measures; Methods; Modality; Modeling; Monte Carlo Method; Mus; Normal tissue morphology; Outcome; Pelvis; Physics; Procedures; Protocols documentation; Proton Radiation; Protons; Quality Control; Radiation; Radiation Dose Unit; Radiation Oncologist; Radiation therapy; Records; Relative Biological Effectiveness; Reporting; Reproducibility; Research Personnel; Role; Safety; Sampling; Site; Standardization; Structure; Support System; System; Techniques; Technology; Time; Tumor Tissue; Validation; Visualization; Work; X-Ray Computed Tomography; animal imaging; biodosimetry; canine model; dosimetry; electron radiation; experimental study; file format; image guided; innovation; ionization; irradiation; millisecond; mouse model; multidisciplinary; novel; operation; particle; procedure safety; quality assurance; restraint; success; tool; translational study; tumor

Summary The central theme of this P01 is to investigate the role of proton/electron/carbon radiation dose rate in normal tissue damage and tumor killing. Delivery of precise doses of radiation with varying dose rates to experimental tumors and normal tissue in animal model systems is a critical task of each project. This Core will provide the dosimetric infrastructure to ensure that each participating institution and radiation modality (electron, proton, and carbon) will have consistent and robust FLASH doses. The proposal includes a multi-disciplinary group with radiation oncologists and biologists who will work very closely with physicists to ensure procedural consistency for FLASH radiation. Reliable and consistent irradiations and determination of dose and dose rate are the primary functions of the Core. The specific aims to enhance capabilities towards this outcome are: Specific Aim 1: Develop and maintain a dosimetry infrastructure for accurate determination and calibration of absorbed physical dose, beam delivery sequence, dose rate and dose-time structure across experimental systems. Specific Aim 2: Develop animal specific treatment techniques and dosimetric support systems. Specific Aim 3: Develop interlock and irradiation logging systems for safe and reproducible experiments across all projects.

总结 本P01的中心主题是研究质子/电子/碳辐射剂量的作用 正常组织损伤和肿瘤杀伤率。提供精确剂量的辐射， 在动物模型系统中，对实验肿瘤和正常组织的不同剂量率是一种 每个项目的关键任务。该核心将提供剂量测定基础设施，以确保 每个参与机构和辐射方式（电子，质子和碳）将有 一致和稳健的FLASH剂量。该提案包括一个多学科小组， 放射肿瘤学家和生物学家，他们将与物理学家密切合作， FLASH辐射的程序一致性。可靠和一致的辐照， 确定剂量和剂量率是核心的主要功能。具体 为实现这一结果而加强能力的目标是： 具体目标1：开发和维护剂量测定基础设施， 吸收物理剂量的测定和校准，射束发射序列，剂量 速率和剂量-时间结构。 具体目标2：开发动物特异性治疗技术和剂量测定支持 系统. 具体目标3：开发互锁和辐射测井系统，以实现安全和 所有项目的可重复实验。