Core B: Physics-Dosimetry Core

摘要 P01的中心主题是研究质子/电子/碳辐射剂量的作用 正常组织损伤率和肿瘤杀伤率。提供精确剂量的辐射 在动物模型系统中，实验肿瘤和正常组织的不同剂量率是一种 每个项目的关键任务。该核心将提供剂量测量基础设施，以确保 每个参与机构和辐射方式(电子、质子和碳)将 稳定可靠的闪光剂量。该提案包括一个由多学科组成的小组， 放射肿瘤学家和生物学家，他们将与物理学家密切合作，确保 闪光辐射的程序一致性。可靠和一致的照射和 确定剂量和剂量率是核心的主要功能。具体的 为实现这一成果而加强能力的目标是： 具体目标1：开发和维护剂量测量基础设施 吸收物理剂量、束流发射顺序、剂量的测定和校准 整个实验系统的速率和剂量-时间结构。 具体目标2：开发动物特定治疗技术和剂量学支持 系统。 具体目标3：开发联锁和辐射测井系统，以确保安全和 所有项目的可重复性实验。

Summary The central theme of this P01 is to investigate the role of proton/electron/carbon radiation dose rate in normal tissue damage and tumor killing. Delivery of precise doses of radiation with varying dose rates to experimental tumors and normal tissue in animal model systems is a critical task of each project. This Core will provide the dosimetric infrastructure to ensure that each participating institution and radiation modality (electron, proton, and carbon) will have consistent and robust FLASH doses. The proposal includes a multi-disciplinary group with radiation oncologists and biologists who will work very closely with physicists to ensure procedural consistency for FLASH radiation. Reliable and consistent irradiations and determination of dose and dose rate are the primary functions of the Core. The specific aims to enhance capabilities towards this outcome are: Specific Aim 1: Develop and maintain a dosimetry infrastructure for accurate determination and calibration of absorbed physical dose, beam delivery sequence, dose rate and dose-time structure across experimental systems. Specific Aim 2: Develop animal specific treatment techniques and dosimetric support systems. Specific Aim 3: Develop interlock and irradiation logging systems for safe and reproducible experiments across all projects.