Core B: Physics-Dosimetry Core

核心 B：物理剂量测定核心

• 批准号: 10573307
• 负责人: Eric Stanton Diffenderfer
• 金额: $ 23.05万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-02-15 至 2027-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10573307
• 关键词: 3D Print; Abdomen; Aftercare; Animal Model; Animals; Area; Biological Models; Calibration; Canis familiaris; Carbon; Cell Survival; Collimator; Consult; Custom; Dose; Dose Rate; Electrons; Ensure; Equipment; Experimental Neoplasms; Goals; Infrastructure; Institution; International; Leg; Linear Energy Transfer; Measurement; Measures; Methods; Modality; Modeling; Monte Carlo Method; Mus; Normal tissue morphology; Outcome; Pelvis; Physics; Procedures; Protocols documentation; Proton Radiation; Protons; Quality Control; Radiation; Radiation Dose Unit; Radiation Oncologist; Radiation therapy; Records; Relative Biological Effectiveness; Reporting; Reproducibility; Research Personnel; Role; Safety; Sampling; Site; Standardization; Structure; Support System; System; Techniques; Technology; Time; Tumor Tissue; Validation; Visualization; Work; X-Ray Computed Tomography; absorption; animal imaging; biodosimetry; canine model; dosimetry; electron radiation; experimental study; file format; image guided; innovation; ionization; irradiation; manufacture; millisecond; mouse model; multidisciplinary; novel; operation; particle; quality assurance; restraint; success; tool; translational study; tumor

Summary The central theme of this P01 is to investigate the role of proton/electron/carbon radiation dose rate in normal tissue damage and tumor killing. Delivery of precise doses of radiation with varying dose rates to experimental tumors and normal tissue in animal model systems is a critical task of each project. This Core will provide the dosimetric infrastructure to ensure that each participating institution and radiation modality (electron, proton, and carbon) will have consistent and robust FLASH doses. The proposal includes a multi-disciplinary group with radiation oncologists and biologists who will work very closely with physicists to ensure procedural consistency for FLASH radiation. Reliable and consistent irradiations and determination of dose and dose rate are the primary functions of the Core. The specific aims to enhance capabilities towards this outcome are: Specific Aim 1: Develop and maintain a dosimetry infrastructure for accurate determination and calibration of absorbed physical dose, beam delivery sequence, dose rate and dose-time structure across experimental systems. Specific Aim 2: Develop animal specific treatment techniques and dosimetric support systems. Specific Aim 3: Develop interlock and irradiation logging systems for safe and reproducible experiments across all projects.

总结