Core B: Physics-Dosimetry Core

核心 B：物理剂量测定核心

• 批准号: 10573307
• 负责人: Eric Stanton Diffenderfer
• 金额: $ 23.05万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-02-15 至 2027-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10573307
• 关键词: 3D Print; Abdomen; Aftercare; Animal Model; Animals; Area; Biological Models; Calibration; Canis familiaris; Carbon; Cell Survival; Collimator; Consult; Custom; Dose; Dose Rate; Electrons; Ensure; Equipment; Experimental Neoplasms; Goals; Infrastructure; Institution; International; Leg; Linear Energy Transfer; Measurement; Measures; Methods; Modality; Modeling; Monte Carlo Method; Mus; Normal tissue morphology; Outcome; Pelvis; Physics; Procedures; Protocols documentation; Proton Radiation; Protons; Quality Control; Radiation; Radiation Dose Unit; Radiation Oncologist; Radiation therapy; Records; Relative Biological Effectiveness; Reporting; Reproducibility; Research Personnel; Role; Safety; Sampling; Site; Standardization; Structure; Support System; System; Techniques; Technology; Time; Tumor Tissue; Validation; Visualization; Work; X-Ray Computed Tomography; absorption; animal imaging; biodosimetry; canine model; dosimetry; electron radiation; experimental study; file format; image guided; innovation; ionization; irradiation; manufacture; millisecond; mouse model; multidisciplinary; novel; operation; particle; quality assurance; restraint; success; tool; translational study; tumor

Summary The central theme of this P01 is to investigate the role of proton/electron/carbon radiation dose rate in normal tissue damage and tumor killing. Delivery of precise doses of radiation with varying dose rates to experimental tumors and normal tissue in animal model systems is a critical task of each project. This Core will provide the dosimetric infrastructure to ensure that each participating institution and radiation modality (electron, proton, and carbon) will have consistent and robust FLASH doses. The proposal includes a multi-disciplinary group with radiation oncologists and biologists who will work very closely with physicists to ensure procedural consistency for FLASH radiation. Reliable and consistent irradiations and determination of dose and dose rate are the primary functions of the Core. The specific aims to enhance capabilities towards this outcome are: Specific Aim 1: Develop and maintain a dosimetry infrastructure for accurate determination and calibration of absorbed physical dose, beam delivery sequence, dose rate and dose-time structure across experimental systems. Specific Aim 2: Develop animal specific treatment techniques and dosimetric support systems. Specific Aim 3: Develop interlock and irradiation logging systems for safe and reproducible experiments across all projects.

概括 该P01的中心主题是研究质子/电子/碳辐射剂量的作用 正常组织损伤和肿瘤杀死的速率。提供精确剂量的辐射 动物模型系统中实验肿瘤和正常组织的剂量率有所不同 每个项目的关键任务。该核心将提供剂量基础架构，以确保 每个参与的机构和辐射方式（电子，质子和碳）将具有 一致且健壮的闪光剂量。该提案包括一个多学科小组 放射肿瘤学家和生物学家将与物理学家紧密合作以确保 闪光辐射的程序一致性。可靠且一致的照射和 剂量和剂量率的确定是核心的主要功能。具体 旨在提高这种结果的能力的目的是： 特定目标1：开发和维护剂量测定基础架构以准确 测定和校准吸收的物理剂量，束输送序列，剂量 跨实验系统的速率和剂量时间结构。 特定目的2：开发特定动物治疗技术和剂量学支持 系统。 特定目标3：开发互锁和辐照记录系统以安全和 在所有项目中可再现的实验。