The Extracellular Matrix in Muscle Atrophy

肌肉萎缩中的细胞外基质

• 批准号: 10335223
• 负责人: Erin E Talbert
• 金额: $ 24.65万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-01-15 至 2023-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10335223
• 关键词: Affect; Anticachexia Agent; Area; Automobile Driving; Award; Body Weight decreased; Cachexia; Cancer Etiology; Cancer Survivor; Cause of Death; Cells; Cessation of life; Characteristics; Collagen; Collagen Fibril; Data; Denervation; Diagnosis; Doctor of Philosophy; Environment; Extracellular Matrix; Fatigue; Fibrosis; Future; Gelatinase B; Gene Expression; Generations; Health; Healthcare; Homeostasis; Human; Insulin Resistance; Intervention; Laboratories; Malignant Neoplasms; Malignant neoplasm of pancreas; Measures; Mediating; Mentors; Metabolic; Microscopy; Molecular; Movement; Mus; Muscle; Muscle Fibers; Muscular Atrophy; Muscular Dystrophies; Myoblasts; Natural regeneration; Ohio; Pathologic; Pathology; Patients; Phenotype; Play; Prevention; Principal Investigator; Proteins; Quality of life; Research; Role; Sirius Red F3B; Skeletal Muscle; Source; Stains; Syndrome; Testing; Transgenic Mice; Universities; cancer cachexia; cancer therapy; cancer type; clinically significant; effective therapy; experience; experimental study; improved; injury and repair; macrophage; mouse model; muscle regeneration; pancreatic cancer patients; prevent; progenitor; programs; repaired; satellite cell; skeletal muscle wasting; skills; targeted treatment; tumor

PROJECT SUMMARY Dr. Erin E. Talbert, Ph.D., seeks to become an independent principal investigator studying muscle wasting due to a variety of conditions, including cancer. Cancer-induced muscle wasting, a component of the cancer cachexia syndrome, is a significant healthcare problem with few treatment options. Cancer cachexia leads to poor patient quality of life and decreased patient survival. Pancreatic cancer patients are particularly affected by cachexia, with perhaps 85% of all pancreatic cancer patients experiencing some weight loss. Additionally, muscle wasting, not tumor burden, is the cause of death for at least 25% of pancreatic cancer patients. Prevention and treatment of cancer-induced muscle wasting will improve survival and quality of life for patients with many different types of cancers. Dr. Talbert's K99/R00 Transition to Independence application “The Extracellular Matrix in Muscle Atrophy” seeks to understand the mechanisms behind cancer-induced muscle wasting. Specifically, Dr. Talbert hypothesizes that extracellular matrix remodeling is a cause of muscle atrophy in cancer. During the K99 portion of this application, Dr. Talbert will gain new skills in microscopy and the generation of transgenic mice to test her hypotheses involving a causative role of the extracellular matrix in muscle atrophy. These skills will be of use in her future independent laboratory, which Dr. Talbert envisions will focus on the role of the extracellular matrix in muscle atrophy. The mentored K99 portion of this proposal will be conducted at The Ohio State University in the laboratory of Dr. Denis Guttridge, a world-leader in muscle wasting research.

项目摘要 博士艾琳·E Talbert博士，寻求成为一个独立的首席研究员研究肌肉萎缩， 包括癌症在内的各种疾病。癌症引起的肌肉萎缩，癌症的一个组成部分， 恶病质综合征是一个重要的健康问题，几乎没有治疗选择。癌症恶病质导致 患者生活质量差，患者生存率降低。胰腺癌患者尤其受到影响 可能有85%的胰腺癌患者体重减轻。此外，本发明还 至少25%的胰腺癌患者的死亡原因是肌肉萎缩，而不是肿瘤负荷。 预防和治疗癌症引起的肌肉萎缩将提高患者的生存率和生活质量 有很多种癌症。 博士Talbert的K99/R00过渡到独立应用程序"肌肉萎缩中的细胞外基质" 旨在了解癌症引起的肌肉萎缩背后的机制。特别是塔尔伯特博士 假设细胞外基质重塑是癌症中肌肉萎缩的原因。在K99 作为该应用程序的一部分，Talbert博士将获得显微镜和转基因小鼠生成方面的新技能 以验证她的假设，包括细胞外基质在肌肉萎缩中的致病作用。这些技能将 在她未来的独立实验室中使用，Talbert博士设想将专注于 细胞外基质在肌肉萎缩中的作用本建议书的辅导K99部分将在 俄亥俄州州立大学的丹尼斯·古特维尔博士的实验室，他是肌肉萎缩研究的世界领导者。

项目成果

Modeling Human Cancer-induced Cachexia.

模拟人类癌症引起的恶病质。

• DOI: 10.1016/j.celrep.2019.07.016
• 发表时间: 2019
• 期刊: Cell reports
• 影响因子: 8.8
• 作者: Talbert,ErinE;Cuitiño,MariaC;Ladner,KatherineJ;Rajasekerea,PriyaniV;Siebert,Melissa;Shakya,Reena;Leone,GustavoW;Ostrowski,MichaelC;Paleo,Brian;Weisleder,Noah;Reiser,PeterJ;Webb,Amy;Timmers,CynthiaD;Eiferman,DanielS;Eva
• 通讯作者: Eva