Neuroprogression across the Psychosis Spectrum in the Early Course of Illness

疾病早期过程中精神病谱系的神经进展

基本信息

  • 批准号:
    10335172
  • 负责人:
  • 金额:
    $ 48.23万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2019
  • 资助国家:
    美国
  • 起止时间:
    2019-05-01 至 2024-01-31
  • 项目状态:
    已结题

项目摘要

PROJECT SUMMARY/ABSTRACT This is an NIMH R01 proposal entitled, “Neuroprogression across the Psychosis Spectrum in the Early Course of Illness.” Neuroprogressive changes that occur through the early years of illness have been described using neurocognitive testing, PET, CT, fMRI, and post-mortem brain studies; however, these studies rely mainly on cross-sectional data, and longitudinal studies involving frequent measurements are rare, limiting our understanding of the actual timing and trajectories of these measures within this critical time period. The development and implementation of targeted and effective treatments is critically dependent on clear understanding of the timing and nature of disease progression in order to target processes amenable to intervention. Thus, there is an urgent need to carefully characterize neuroprogression in the early course of psychosis if we are to develop effective interventions to target areas of preserved functioning, potentially preventing further decline and chronic loss of functioning. This knowledge gap severely limits our ability to develop targeted treatments when they may be most effective, and to tailor treatment to patients' needs. The aim of the present proposal is the systematic, multimodal characterization of neuroprogression throughout the early course of illness in a cross-diagnostic sample of patients with psychosis using an accelerated longitudinal design. First, we will measure neurocognitive and neurobiological change over the first eight years of illness in order to characterize variability of timing and magnitude of neuroprogression across key measures. Second, we will assess the predictive utility of neuroprogressive trajectories on clinical and functional outcomes. We will also leverage the heterogeneity in baseline cognitive and brain measures to characterize patients by neuroprogressive profile and test whether baseline profiles offer improved prediction of clinical and functional course. The richness of these data will also position us to explore heterogeneity of neuroprogressive trajectories and their associations with clinical and functional outcomes. It has been argued that combining data from clinical, structural and functional imaging, and cognitive measures is superior to monomodal data in the prediction of course and outcome (6). Findings from this project will hasten identification of actionable treatment targets that are closely associated with clinical outcomes, and provide guidance for individualized treatment implementation during a critical period where early intervention strategies may be most effective. Notably, this proposal aims to build on the Human Connectome Project for Early Psychosis (U01MH109977, PI: Shenton) by utilizing the same high-quality methodology and adding longitudinal assessments to baseline data collection already underway, maximizing both the power of the present study and the utility of the HCP-EP data. The PI is an early stage investigator and K23 Awardee with a career focus on characterization of the nature and course of multidimensional symptom domains (e.g. cognition, reward processing), and targeted treatment approaches in psychosis.
项目总结/文摘

项目成果

期刊论文数量(0)
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会议论文数量(0)
专利数量(0)

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KATHRYN Eve LEWANDOWSKI其他文献

KATHRYN Eve LEWANDOWSKI的其他文献

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{{ truncateString('KATHRYN Eve LEWANDOWSKI', 18)}}的其他基金

Systematic Evaluation of the Effects of Cognitive Remediation across Affective and Non-Affective Psychosis
认知矫正对情感性和非情感性精神病效果的系统评估
  • 批准号:
    9977312
  • 财政年份:
    2020
  • 资助金额:
    $ 48.23万
  • 项目类别:
Neuroprogression across the Psychosis Spectrum in the Early Course of Illness
疾病早期过程中精神病谱系的神经进展
  • 批准号:
    9918996
  • 财政年份:
    2019
  • 资助金额:
    $ 48.23万
  • 项目类别:
Neuroprogression across the Psychosis Spectrum in the Early Course of Illness
疾病早期过程中精神病谱系的神经进展
  • 批准号:
    10083768
  • 财政年份:
    2019
  • 资助金额:
    $ 48.23万
  • 项目类别:
Neuroprogression across the Psychosis Spectrum in the Early Course of Illness
疾病早期过程中精神病谱系的神经进展
  • 批准号:
    10560521
  • 财政年份:
    2019
  • 资助金额:
    $ 48.23万
  • 项目类别:
Characterization of Variability in Motivation and Reward in Psychosis
精神病动机和奖励变异性的表征
  • 批准号:
    9314825
  • 财政年份:
    2017
  • 资助金额:
    $ 48.23万
  • 项目类别:
Efficacy of a Cognitive Remediation Treatment Program for Bipolar Disorder
双相情感障碍认知矫正治疗方案的疗效
  • 批准号:
    8231309
  • 财政年份:
    2011
  • 资助金额:
    $ 48.23万
  • 项目类别:
Efficacy of a Cognitive Remediation Treatment Program for Bipolar Disorder
双相情感障碍认知矫正治疗方案的疗效
  • 批准号:
    8110347
  • 财政年份:
    2011
  • 资助金额:
    $ 48.23万
  • 项目类别:
Efficacy of a Cognitive Remediation Treatment Program for Bipolar Disorder
双相情感障碍认知矫正治疗方案的疗效
  • 批准号:
    8415544
  • 财政年份:
    2011
  • 资助金额:
    $ 48.23万
  • 项目类别:
Efficacy of a Cognitive Remediation Treatment Program for Bipolar Disorder
双相情感障碍认知矫正治疗方案的疗效
  • 批准号:
    8604753
  • 财政年份:
    2011
  • 资助金额:
    $ 48.23万
  • 项目类别:
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