KLF control of aging and age-associated cardiovascular disease

KLF 控制衰老和与年龄相关的心血管疾病

• 批准号: 10335213
• 负责人: MUKESH Kumar JAIN
• 金额: $ 95.1万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-02-01 至 2022-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10335213
• 关键词: Age; Aging; Atherosclerosis; Blood Vessels; Caenorhabditis elegans; Cardiac; Cardiovascular Diseases; Cardiovascular system; Control Locus; Elderly; Failure; Family; Guidelines; Heart Hypertrophy; Immunity; Inflammation; Inflammatory; Laboratories; Life; Link; Longevity; Mammals; Metabolism; Molecular; Myelogenous; Prevalence; Publishing; Role; Therapeutic; Work; cardiovascular risk factor; healthspan; insight

(7) Project Summary / Abstract Advancing age is a major independent risk factor for cardiovascular disease. The prevalence of specific cardiovascular conditions such as cardiac hypertrophy/failure, atherosclerosis, and inflammation increase with age. Previous studies by the applicant's laboratory illuminated essential roles for KLFs in control of immunity, metabolism, and impact on the cardiovascular system. Nascent observations by the applicant build on the published corpus of work and identify KLFs as a heretofore unappreciated molecular control locus governing both lifespan and healthspan across metazoan life. The current application seeks to (a) determine which mammalian KLFs are linked to aging, (b) determine the effect of manipulating KLF4 on cardiac and vascular healthspan in aging mammals, and (c) determine the effect of manipulating myeloid KLF2 on aging/age-associated inflammatory states. Completion of the outlined work will provide fundamental insights with therapeutic implications regarding aging and age-associated cardiovascular disease.

(7)项目摘要/摘要