CWRU- Cardiovascular Research Training Program

CWRU-心血管研究培训计划

• 批准号: 10225361
• 负责人: MUKESH Kumar JAIN
• 金额: $ 28.66万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10225361
• 关键词: Cardiovascular system; Research Training; Training Programs

Project Summary/Abstract The goal of this Cardiovascular Research Training Program (CRTP) is to provide outstanding training in basic cardiovascular research to promising predoctoral students and highly qualified MD or PhD postdoctoral fellows. The program includes 29 senior trainers and 8 junior trainers from 6 PhD programs and 4 clinical divisions at Case Western Reserve University. The recruited faculty are known for excellence in research, ample NIH funding, and robust research space. The Cardiovascular Research Institute (CVRI) serves as the integrating platform for all trainers on this grant. Training focuses on relating the basic approaches of molecular and cellular biology, physiology, biophysics, biomedical engineering, and imaging to mechanistic questions and problems pertinent to the cardiovascular system in health and disease, with particular emphasis on (a) Cardiovascular metabolism and inflammation, (b) Cardiac function, failure, and arrhythmia, (c) Vascular pathophysiology, and (d) Cardiovascular tissue engineering and imaging. The majority of student recruitment is through the Medical Scientist and Biomedical Sciences Training Programs, and includes a strong commitment to the recruitment of women and under-represented minorities. Predoctoral training is accomplished in PhD programs in Biomedical Engineering, Epidemiology & Biostatistics, Molecular Medicine, Pharmacology, Pathology, and Physiology & Biophysics. The basic coursework and guided training in research skills provided by these departmental programs is supplemented and enhanced by CRTP-specific components. These include completion of a required graduate course in Cardiovascular Physiology, an exciting Immersion Experience in Cardiovascular Healthcare, participation in a weekly seminar series, a monthly journal club, and an annual CVRI research retreat. A CRTP faculty committee that includes senior trainers and junior trainers, who are developing independent programs in cutting-edge areas of cardiovascular research, mentor each trainee. Postdoctoral trainees, including physicians from the Harrington Physician Scientist Pathway, are appointed via their recruitment to CRTP trainer labs and will also participate in the Cardiovascular Healthcare Immersion, CVRI seminars/retreats/journal club, and the mentoring process. In total, this application seeks 8 positions (4 predoctoral and 4 postdoctoral) per year.

项目摘要/摘要 该心血管研究培训计划(CRTP)的目标是提供出色的基础培训 为有前途的博士后学生和高素质的医学博士或博士后研究员提供心血管研究。 该项目包括来自6个博士项目和4个临床科室的29名高级培训师和8名初级培训师 凯斯西储大学。招聘的教员以研究方面的卓越而闻名，NIH就是其中之一 资金和强大的研究空间。心血管研究所(CVRI)是 为这笔赠款上的所有培训人员提供平台。培训的重点是将分子和细胞的基本方法联系起来 生物学、生理学、生物物理学、生物医学工程和成像到机械问题和问题 与健康和疾病中的心血管系统有关，特别强调(A)心血管 代谢和炎症，(B)心功能、衰竭和心律失常，(C)血管病理生理学，和 (D)心血管组织工程和成像。大部分的招生工作是通过医疗队进行的 科学家和生物医学培训计划，并包括对招聘 妇女和代表性不足的少数群体。在生物医学博士项目中完成博士前培训 工程学、流行病学和生物统计学、分子医学、药理学、病理学和生理学 生物物理学。这些部门提供的研究技能的基本课程和指导培训 程序得到CRTP特定组件的补充和增强。这些包括完成所需的 心血管生理学研究生课程：一次激动人心的心血管沉浸式体验 医疗保健，参加每周一次的系列研讨会，每月一次的杂志俱乐部，以及一年一度的CVRI研究 撤退。CRTP教职员工委员会，包括高级培训师和初级培训师，他们正在制定 心血管研究前沿领域的独立项目，指导每一位学员。博士后 实习生，包括来自哈灵顿医生科学家路径的医生，通过他们的 招募到CRTP培训师实验室，并将参与心血管保健沉浸，CVRI 研讨会/务虚会/杂志俱乐部，以及指导过程。这份申请总共招聘了8个职位(4个 博士后和4名博士后)每年。

项目成果

Standardized microfluidic assessment of red blood cell-mediated microcapillary occlusion: Association with clinical phenotype and hydroxyurea responsiveness in sickle cell disease.

• DOI: 10.1111/micc.12662
• 发表时间: 2021-03
• 期刊: Microcirculation (New York, N.Y. : 1994)
• 作者: Man Y;Kucukal E;An R;Bode A;Little JA;Gurkan UA
• 通讯作者: Gurkan UA

Emerging functional microfluidic assays for the study of thromboinflammation in sickle cell disease.

• DOI: 10.1097/moh.0000000000000731
• 发表时间: 2022-11-01
• 期刊: CURRENT OPINION IN HEMATOLOGY
• 影响因子: 3.2
• 作者: An, Ran;Gurkan, Umut A.
• 通讯作者: Gurkan, Umut A.

Fecal Microbiome Composition Does Not Predict Diet-Induced TMAO Production in Healthy Adults.

• DOI: 10.1161/jaha.121.021934
• 发表时间: 2021-11-02
• 期刊: Journal of the American Heart Association
• 影响因子: 5.4
• 作者: Ferrell M;Bazeley P;Wang Z;Levison BS;Li XS;Jia X;Krauss RM;Knight R;Lusis AJ;Garcia-Garcia JC;Hazen SL;Tang WHW
• 通讯作者: Tang WHW

Microfluidic electrical impedance assessment of red blood cell-mediated microvascular occlusion.

• DOI: 10.1039/d0lc01133a
• 发表时间: 2021-03-21
• 期刊: Lab on a chip
• 影响因子: 6.1
• 作者: Man Y;Maji D;An R;Ahuja SP;Little JA;Suster MA;Mohseni P;Gurkan UA
• 通讯作者: Gurkan UA

Inhibition of Band 3 tyrosine phosphorylation: a new mechanism for treatment of sickle cell disease.

• DOI: 10.1111/bjh.16671
• 发表时间: 2020-08
• 期刊: British journal of haematology
• 影响因子: 6.5
• 作者: Noomuna P;Risinger M;Zhou S;Seu K;Man Y;An R;Sheik DA;Wan J;Little JA;Gurkan UA;Turrini FM;Kalfa T;Low PS
• 通讯作者: Low PS