CARDIOVASCULAR OUTCOMES RESEARCH TRAINING PROGRAM

项目概要/摘要 作为美国死亡和残疾的主要原因，心血管疾病受益匪浅 来自用于改善患者护理的巨额研究投资。然而，该技术的应用 常规临床实践中的知识是可变的，并且对更多以患者为中心的结果的评估， 包括患者的症状、功能和生活质量，都是迫切需要的。这些知识不仅 差距限制了美国医疗保健改善的潜力，但报销规模不断变化 基于价值的支付模式为心血管结果研究人员创造了无与伦比的需求。 此次续签申请旨在继续一项非常成功的博士后学者培训计划 独立进行以临床为导向的结果研究。它扩展并改进了密苏里大学—— 堪萨斯城 (UMKC) 的成果研究培训计划在中西部地区独一无二，可作为 我们地区的中央统一研究计划。为期 2 年的培训计划有 3 个协同组成部分：1) 临床研究的基础（包括具有临床研究的生物信息学硕士学位 重点），2）结果研究的专业技能加上学术“生存技能”（我们的结果- 基于核心课程），3）实践研究。研究经验的特点包括多 学科小组辅导，个性化辅导，满足每位学员的需求；访问众多 现有数据以及用于主要数据收集和实施的临床人群；培训于 创业精神；以及经验丰富的统计支持。现有计划的增强计划 包括 1) 与密苏里大学系统进行更强有力的合作，该系统正在投资 NextGen 精准医学研究所，我们的项目是精准医疗保健的核心支柱 交货； 2) 增加对临床试验设计和执行的参与； 3）进入新社区 19 家地区医院合作创新医疗保健服务以提高其价值 (www.kcqvic.org) 更深入地接触实施研究。管理该计划将是一个经验丰富的计划 董事，由具有经济学专业知识的合格副董事和助理董事以及导师提供支持 和决策分析；大型数据库分析；生物信息学；定性和实施研究；学习 设计、方法和统计；患者和临床医生的行为改变；以社区为基础的参与 研究；创业精神；共享医疗决策和以患者为中心的研究；多学科 心血管研究；差异研究；和风险模型和临床工具的创建，以及 国家领导人咨询委员会。总的来说，我们忠诚的团队将提供正式的培训， 指导和评估计划，以继续并加强我们之前在支持能力方面的成功 受训者对科学文献做出重大贡献并开始成功的学术生涯 研究职业。

Project Summary/Abstract As the leading cause of death and disability in the United States, cardiovascular disease has benefitted from immense research investments to improve the care of afflicted patients. However, the application of this knowledge in routine clinical practice has been variable and the evaluation of more patient-centered outcomes, including patients’ symptoms, function and quality of life, are desperately needed. Not only do these knowledge gaps limit the potential for US healthcare to improve, but evolving changes in reimbursement from a volume- to value-based payment models have created an unparalleled demand for cardiovascular outcomes researchers. This renewal application seeks to continue a highly successful program for training post-doctoral scholars to independently perform clinically-oriented outcomes research. It extends and improves the University of Missouri- Kansas City (UMKC)’s outcomes research training program, which is unique in the Midwest and serves as a central unifying research program for our region. The 2-year training program has 3 synergistic components: 1) a basic foundation of in clinical research (including a Masters degree in bioinformatics with a clinical research emphasis), 2) specialized skills for outcomes research coupled with academic ‘survival skills’ (our outcomes- based core curriculum), and 3) hands-on research. Hallmarks of the research experiences include multi- disciplinary group mentorship, individualized mentorship to meet each trainee’s needs; access to numerous existing data, as well as clinical populations for primary data collection and implementation; training in entrepreneurship; and highly experienced statistical support. Enhancements planned for the existing program include 1) a more robust collaboration with the University of Missouri system, which is investing in the NextGen Precision Medicine institute and for which our program serves as the central pillar for precision healthcare delivery; 2) increased engagement in clinical trial design and execution; and 3) access to a new community collaboration of 19 regional hospitals innovating healthcare delivery to improve its value (www.kcqvic.org) for deeper exposure to implementation research. Administering the program will be an experienced program director, supported by well-qualified associate and assistant directors and mentors with expertise in economics and decision analysis; large database analysis; bioinformatics; qualitative and implementation research; study design, methodology and statistics; patient and clinician behavior change; community-based participatory research; entrepreneurship; shared medical decision-making and patient-centered research; multi-disciplinary cardiovascular research; disparities research; and risk models and creation of clinical tools, as well as an advisory committee of national leaders. Collectively, our committed team will provide a formal training, mentorship and evaluation program to continue and enhance our prior success in supporting the ability of trainees to make significant contributions to the scientific literature and to embark on successful academic research careers.