CARDIOVASCULAR OUTCOMES RESEARCH TRAINING PROGRAM

项目概要/摘要 作为美国死亡和残疾的主要原因，心血管疾病已经受益于 从巨大的研究投资，以改善病人的护理。然而，这一应用 常规临床实践中的知识是可变的， 包括患者的症状、功能和生活质量。这些知识不仅 差距限制了美国医疗保健改善的潜力，但报销从数量到成本的不断变化， 基于价值的支付模式对心血管结局研究人员产生了前所未有的需求。 这一更新申请旨在继续一个非常成功的培养博士后学者的计划， 独立进行临床导向的成果研究。它扩展和改善了密苏里州大学- 堪萨斯城（UMKC）的成果研究培训计划，这是独特的中西部，并作为一个 我们地区的中央统一研究计划。为期2年的培训计划有3个协同组成部分：1） 临床研究的基本基础（包括生物信息学硕士学位和临床研究） 强调），2）专业技能的成果研究加上学术'生存技能'（我们的成果- 基础课程），和3）动手研究。研究经验的特点包括多方面- 学科小组指导，个性化的指导，以满足每个学员的需求;获得众多 现有数据，以及用于主要数据收集和实施的临床人群; 企业家精神;以及经验丰富的统计支持。计划对现有程序进行的增强 包括1）与密苏里州大学系统进行更有力的合作，该系统正在投资NextGen 精准医学研究所，我们的计划作为精准医疗的中心支柱 交付; 2）增加参与临床试验设计和执行; 3）进入新社区 19家地区医院合作创新医疗服务，以提高其价值（www.kcqvic.org）， 更深入地接触实施研究。管理该计划将是一个经验丰富的计划 主任，由具有经济学专门知识的合格协理主任和助理主任以及导师提供支持 与决策分析;大型数据库分析;生物信息学;定性与实施研究;研究 设计、方法学和统计学;患者和临床医生行为改变;社区参与 研究;创业;共享医疗决策和以患者为中心的研究;多学科 心血管研究;差异研究;风险模型和临床工具的创建，以及 国家领导人咨询委员会。总的来说，我们承诺的团队将提供正式的培训， 指导和评估计划，以继续和加强我们先前的成功，支持能力， 学员作出重大贡献的科学文献和走上成功的学术 研究生涯。

Project Summary/Abstract As the leading cause of death and disability in the United States, cardiovascular disease has benefitted from immense research investments to improve the care of afflicted patients. However, the application of this knowledge in routine clinical practice has been variable and the evaluation of more patient-centered outcomes, including patients’ symptoms, function and quality of life, are desperately needed. Not only do these knowledge gaps limit the potential for US healthcare to improve, but evolving changes in reimbursement from a volume- to value-based payment models have created an unparalleled demand for cardiovascular outcomes researchers. This renewal application seeks to continue a highly successful program for training post-doctoral scholars to independently perform clinically-oriented outcomes research. It extends and improves the University of Missouri- Kansas City (UMKC)’s outcomes research training program, which is unique in the Midwest and serves as a central unifying research program for our region. The 2-year training program has 3 synergistic components: 1) a basic foundation of in clinical research (including a Masters degree in bioinformatics with a clinical research emphasis), 2) specialized skills for outcomes research coupled with academic ‘survival skills’ (our outcomes- based core curriculum), and 3) hands-on research. Hallmarks of the research experiences include multi- disciplinary group mentorship, individualized mentorship to meet each trainee’s needs; access to numerous existing data, as well as clinical populations for primary data collection and implementation; training in entrepreneurship; and highly experienced statistical support. Enhancements planned for the existing program include 1) a more robust collaboration with the University of Missouri system, which is investing in the NextGen Precision Medicine institute and for which our program serves as the central pillar for precision healthcare delivery; 2) increased engagement in clinical trial design and execution; and 3) access to a new community collaboration of 19 regional hospitals innovating healthcare delivery to improve its value (www.kcqvic.org) for deeper exposure to implementation research. Administering the program will be an experienced program director, supported by well-qualified associate and assistant directors and mentors with expertise in economics and decision analysis; large database analysis; bioinformatics; qualitative and implementation research; study design, methodology and statistics; patient and clinician behavior change; community-based participatory research; entrepreneurship; shared medical decision-making and patient-centered research; multi-disciplinary cardiovascular research; disparities research; and risk models and creation of clinical tools, as well as an advisory committee of national leaders. Collectively, our committed team will provide a formal training, mentorship and evaluation program to continue and enhance our prior success in supporting the ability of trainees to make significant contributions to the scientific literature and to embark on successful academic research careers.