BLRD Research Career Scientist Award Application

BLRD 研究职业科学家奖申请

基本信息

  • 批准号:
    10337030
  • 负责人:
  • 金额:
    --
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-10-01 至 2027-09-30
  • 项目状态:
    未结题

项目摘要

The overall research program of the applicant seeks to develop new insights and understanding of the key molecular mechanisms regulating the functions of, and interactions between immune cells, with a particular emphasis on B and T lymphocytes, and B cell-derived tumors. The ultimate goal is to apply this knowledge to development of improved measures to both prevent and treat diseases involving lymphocytes, as well as to inform the clinical selection of the optimal available treatments for a specific Veteran's tumor. The basic science investigations that began in the applicant's laboratory 30 years ago are now leading to important collaborations with physician-scientists to translate the findings of these studies into treatments and clinical trials. The projects to be pursued during the proposed funding period of this SRCS award, and their relevance to Veteran health, include the following. 1) Define the role of the signaling protein TNF Receptor Associated Protein 3 (TRAF3) as a tumor suppressor in B cell cancers. B cell lymphoma (BCL) and multiple myeloma (MM), the most common cancers of lymphocytes in humans, are over-represented in the Veteran population. In both BCL and MM, loss-of-function TRAF3 mutations are common, and the applicant discovered that post-translational loss of TRAF3 protein can also occur. The proposed project will continue to define how TRAF3 restrains survival pathways which, when dysregulated, contribute to BCL/MM pathogenesis, define how TRAF3 regulates BCL metabolism, determine the mechanisms and biological consequences of post-translational loss of TRAF3 protein in the B cells of aging humans, and develop new biomarkers for MM-initiating cells. Importantly, all these projects will involve ongoing collaborations with clinician colleagues. 2) Determine clinically-relevant roles of TRAF3 in other immune cell types. The applicant's lab will continue studies revealing how TRAF3 enhances and regulates the function of T lymphocytes, critical to human immune responses to infectious disease and tumors. A new project, in collaboration with two physician-scientists, investigates the consequences of monoallelic TRAF3 disruption in humans, leading to chronic susceptibility to infections, and autoimmunity. We strongly suspect that this genetic defect is in fact much more widespread than previously appreciated. 3) Translate the applicant's knowledge of CD40 function into clinical application. This involves projects that seek to optimize an antagonistic anti-human CD40 antibody for use in blocking transplant rejection, a clinical problem of relevance to Veterans, and to understand the protective role played by CD40 in resistance to Ebola virus infection. 4) Provide key expertise in B lymphocyte biology to funded collaborative projects in MM and pancreatic cancer. Both these malignancies occur at higher-than-normal rates in the Veteran population. In addition to these 4 major project areas, which form the major research Aims, the applicant will continue her strong commitment and activities in mentoring and teaching the next generation of biomedical researchers, both PhD and MD, and serve the scientific community in committee participation, review of grants and manuscripts, and leadership roles in scientific societies.
申请人的整体研究计划寻求发展新的见解和理解的关键

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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GAIL A. BISHOP其他文献

GAIL A. BISHOP的其他文献

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{{ truncateString('GAIL A. BISHOP', 18)}}的其他基金

Regulation of B cell signaling in autoimmunity by TRAF3
TRAF3 对自身免疫中 B 细胞信号传导的调节
  • 批准号:
    10272524
  • 财政年份:
    2021
  • 资助金额:
    --
  • 项目类别:
Regulation of B cell signaling in autoimmunity by TRAF3
TRAF3 对自身免疫中 B 细胞信号传导的调节
  • 批准号:
    10669670
  • 财政年份:
    2021
  • 资助金额:
    --
  • 项目类别:
Regulation of B cell signaling in autoimmunity by TRAF3
TRAF3 对自身免疫中 B 细胞信号传导的调节
  • 批准号:
    10457447
  • 财政年份:
    2021
  • 资助金额:
    --
  • 项目类别:
Regulation of B cell signaling in autoimmunity by TRAF3
TRAF3 对自身免疫中 B 细胞信号传导的调节
  • 批准号:
    10533971
  • 财政年份:
    2021
  • 资助金额:
    --
  • 项目类别:
Regulation of B cell signaling in autoimmunity by TRAF3
TRAF3 对自身免疫中 B 细胞信号传导的调节
  • 批准号:
    10728904
  • 财政年份:
    2021
  • 资助金额:
    --
  • 项目类别:
Loss of TRAF3 in aging B lymphocytes
衰老 B 淋巴细胞中 TRAF3 缺失
  • 批准号:
    10116246
  • 财政年份:
    2020
  • 资助金额:
    --
  • 项目类别:
BLRD Research Career Scientist Award Application
BLRD 研究职业科学家奖申请
  • 批准号:
    10514631
  • 财政年份:
    2020
  • 资助金额:
    --
  • 项目类别:
Molecular regulation of T cell activation signals by TRAF3
TRAF3 对 T 细胞激活信号的分子调节
  • 批准号:
    9211288
  • 财政年份:
    2016
  • 资助金额:
    --
  • 项目类别:
Molecular regulation of T cell activation signals by TRAF3
TRAF3 对 T 细胞激活信号的分子调节
  • 批准号:
    9075045
  • 财政年份:
    2016
  • 资助金额:
    --
  • 项目类别:
Understanding and applying innate and adaptive immune signal interactions
了解和应用先天性和适应性免疫信号相互作用
  • 批准号:
    8621977
  • 财政年份:
    2012
  • 资助金额:
    --
  • 项目类别:
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