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OspC and its role in defining host range and dissemination properties

OspC and its role in defining host range and dissemination properties
OspC 及其在定义主机范围和传播属性中的作用
批准号：
10345736
负责人：
RICHARD T MARCONI
金额：
$57.78万
依托单位：
VIRGINIA COMMONWEALTH UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
项目状态：
未结题
起止时间：
2022-08-01 至 2026-07-31
来源：
https://reporter.nih.gov/project-details/10345736
关键词：
AffinityAllelesAmino Acid SubstitutionBindingBiologicalBirdsBorreliaBorrelia afzeliiBorrelia burgdorferiBorrelia burgdorferi GroupBorrelia gariniiChargeComplementComplement 4bCoupledDataDistalElectrostaticsExtracellular MatrixGenomeHumanIncidenceIndividualInfectionIxodesKineticsLigand BindingLigand Binding DomainLigandsLinkLyme DiseaseMaintenanceMammalsMediatingMembraneMembrane ProteinsMolecularMusMutateOrganOryctolagus cuniculusOspC proteinOutcomePathogenesisPathogenicityPlasminogenPlayPositioning AttributePreventivePropertyProtein CProteinsPublic HealthRecombinant ProteinsResearchRoleSite-Directed MutagenesisSolventsStructureTestingTherapeuticTick-Borne DiseasesTicksTransgenic OrganismsVariantVirulence FactorsWorkantigen diagnosticbasecitrate carriercompanion animaldimerenzooticgenetic approachimprovedin vivoinnovationmutantpathogentick populationtick transmissiontissue tropismvaccine development

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中文摘要
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英文摘要
Project summary: Lyme disease is the most common tick-borne disease in the northern hemisphere. The incidence of Lyme disease is steadily increasing as the Ixodes tick population expands. This proposal will identify the critical functional determinants of outer surface protein C (OspC), an essential virulence factor. In addition, we will determine how sequence variation in OspC influences infectivity and dissemination properties. Cutting edge genetic approaches will be employed to dissect the role that OspC plays in the pathobiology of the Lyme disease spirochetes. The outcome of these analyses will also advance ongoing efforts to develop vaccines and diagnostic antigens for use in humans.
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OspC and its role in defining host range and dissemination properties
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    10674690
  • 项目类别：
  • 资助金额：
    $55.28万
  • 财政年份：
    2022
  • 负责人：
    RICHARD T MARCONI
  • 依托单位：
    VIRGINIA COMMONWEALTH UNIVERSITY
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  • 项目类别：
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    2019
  • 负责人：
    RICHARD T MARCONI
  • 依托单位：
    VIRGINIA COMMONWEALTH UNIVERSITY
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    10219068
  • 项目类别：
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  • 财政年份：
    2019
  • 负责人：
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  • 依托单位：
    VIRGINIA COMMONWEALTH UNIVERSITY
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  • 批准号：
    10438610
  • 项目类别：
  • 资助金额：
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  • 财政年份：
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  • 负责人：
    RICHARD T MARCONI
  • 依托单位：
    VIRGINIA COMMONWEALTH UNIVERSITY
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