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Multimodal Imaging in Frontotemporal Degeneration

额颞叶变性的多模态成像

基本信息

批准号：
10343692
负责人：
HOWARD J ROSEN
金额：
$ 19.16万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-09-01 至 2024-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10343692
关键词：
Address Adverse effects Age Age of Onset Aging Behavioral Biological Biological Markers Blood C9ORF72 California Caring Categories Cerebrum Clinical Clinical Trials Clinical dementia rating scale Cognitive Collaborations Data Dementia Development Diagnosis Discipline Disease Disease Marker Early Diagnosis Education Educational Curriculum Enrollment Family Frontotemporal Dementia Funding Future Genes Genetic Goals Grant Image Individual Institutes Language Leadership Light Liquid substance Literature Maps Measurement Measures Memory Mentors Methods Mid-Career Clinical Scientist Award (K24)Mission Modeling Multimodal Imaging Mutation Nerve Degeneration Neurodegenerative Disorders Neurologist Neurology Neuronal Injury Neuropsychology Patient Selection Patients Persons Pharmaceutical Preparations Psychiatry Research Research Personnel Research Training Risk San Francisco Sum Symptoms Time Training Training Programs Universities Work accurate diagnosis autosomal dominant mutation base brain health brain volume cohort frontotemporal degeneration improved individual patient member motor symptom multidisciplinary multimodality mutation carrier neurofilament patient oriented research prevent rate of change recruit research clinical testing symptom treatment teacher

项目摘要

PROJECT SUMMARY This is the first renewal application for a K24 award for Dr. Howard Rosen, a behavioral neurologist at the University of California, San Francisco. Dr. Rosen’s research focuses on early recognition and longitudinal tracking of atypical neurodegenerative diseases, in particular frontotemporal dementia (FTD). The work takes place at the UCSF Memory and Aging Center, a large multidisciplinary group dedicated to research, care and education in neurodegenerative diseases. In the first cycle of this project, Dr. Rosen served as a mentor for 21 individuals at various stages of training and accomplished his goals of expanding his research on familial forms of FTD. He helped to implement new strategies for diagnosis of FTD through collaboration with the UCSF Department of Psychiatry. Dr. Rosen also expanded the reach of his educational expertise by leading development of the educational curriculum for a new training program called the Global Brain Health Institute, the mission of which is to address worldwide threats to brain health through training of professionals from a variety of disciplines. With continued K24 funding, Dr. Rosen will continue his leadership of research and training at the MAC, focusing on improving methods for measuring change in FTD for use in clinical trials and expanding collaboration with UCSF Psychiatry. He will improve his expertise as an investigator through selective coursework and collaboration with expert colleagues at UCSF.

项目摘要这是该医院的行为神经学家霍华德·罗森博士首次申请K24奖项的延续加州大学旧金山分校弗朗西斯科。罗森博士的研究重点是早期识别和纵向跟踪非典型神经退行性疾病，特别是额颞叶痴呆（FTD）。这项工作需要地点在加州大学旧金山分校记忆和衰老中心，一个大型的多学科小组，致力于研究，护理和神经退行性疾病的教育。在该项目的第一个周期，罗森博士担任21名在不同的训练阶段的个人，并完成了他的目标，扩大他的研究家庭形式的FTD。通过与UCSF的合作，他帮助实施了FTD诊断的新策略精神病学系。罗森博士还通过领导为一个名为全球大脑健康研究所的新培训项目开发教育课程，其使命是通过培训来自世界各地的专业人员，各种学科。随着K24的持续资助，罗森博士将继续领导研究，在MAC进行培训，重点是改进临床试验中使用的FTD变化测量方法，扩大与UCSF精神病学的合作。他将通过以下方式提高自己作为调查员的专业知识：选择性课程以及与加州大学旧金山分校的专家同事合作。