Multimodal imaging in frontotemporal degeneration

描述（由申请人提供）：该基金将用于支持行为神经学家霍华德罗森博士，他的研究重点是早期识别，更好地表征和纵向跟踪非典型神经退行性疾病，特别是额颞叶变性（FTLD），使用临床和实验行为评估和成像。罗森博士长期以来一直对指导感兴趣。本提案的目标是：1）为罗森博士提供时间，以便为越来越多的临床研究者提供指导; 2）为他提供时间，以便他增强作为研究者的技能; 3） 提高他进行患者导向研究（POR）的能力，并将这些技能传授给他的学员。为了实现这些目标，他将提高自己在统计分析方面的技能，作为一名导师，加强自我发展的努力，并制定一个更正式的指导计划。此外，这笔赠款将特别有助于支持罗森博士的新目标，其中包括提高他对老年精神病评估的理解，将这些方法引入他的研究，并接触更多对精神病症状感兴趣的学员。对罗森博士和他的学员的培训将通过选定的课程和研究活动来完成，包括数据分析和手稿准备，使用来自罗森博士正在进行的项目的数据，包括额颞叶变性神经成像倡议，以及正在进行的研究痴呆症自我意识受损的认知和情感基础的项目。由于他在多模态脑成像和情绪研究的心理生理学和行为方法学方面的经验，罗森博士拥有独特的专业知识，可以使具有神经病学、精神病学和心理学背景的学员受益。此外，罗森博士正在提出一个新项目，该项目将在对受导致FTLD（f-FTLD）突变影响的家族成员的临床评估中增加DSM（SCID）结构化临床访谈。该项目的目的是量化早期f-FTLD中传统精神病综合征的频率，并评估精神病诊断在预测一年内皮质变薄率方面的价值。该研究将更好地表征f-FTLD的早期临床表现，并提供有关可能发生散发性FTLD之前的精神症状的指导，然后可以在未来的研究中进行研究。

DESCRIPTION (provided by applicant): This grant is being requested to support Dr. Howard Rosen, a behavioral neurologist whose research has focused on early recognition, better characterization and longitudinal tracking of atypical neurodegenerative diseases, in particular frontotemporal lobar degeneration (FTLD), using clinical and experimental behavioral assessment and imaging. Dr. Rosen has a longstanding interest in mentoring. The goals of this proposal are 1) to support time for Dr. Rosen to provide mentoring to a growing number of clinical researchers, 2) to support time for him to augment his skills as an investigator and 3) to increase his ability to conduct patient oriented research (POR) and to impart these skills to his mentees. To accomplish these goals he will augment his skills in statistical analysis, increase his efforts in self-development as a mentor and develop a more formal mentoring program. In addition, this grant will be particularly instrumental in supporting Dr. Rosen's new goals, which include improving his understanding of geriatric psychiatric assessment, introducing these approaches into his research and reaching out to more trainees interested in psychiatric symptoms. Training for both Dr. Rosen and his mentees will be accomplished through selected coursework and research activities including data analysis and manuscript preparation, using the data from Dr. Rosen's ongoing projects, including the Frontotemporal Lobar Degeneration Neuroimaging Initiative, and an ongoing project to study the cognitive and emotional basis of impaired self-awareness in dementia. Because of his experience in both multimodal brain imaging and psychophysiological and behavioral methodology from emotions research, Dr. Rosen has unique expertise that can benefit trainees with neurology, psychiatry and psychology backgrounds. In addition, Dr. Rosen is proposing a new project, which will add the Structured Clinical Interview for DSM (SCID) to the clinical assessment of members of families affected by mutations that cause FTLD (f-FTLD). The aims of the project are to quantify the frequency of traditional psychiatric syndromes in early f-FTLD, and to assess value of psychiatric diagnosis in predicting the rate of cortical thinning over one year. The study will provide better characterization of the early clinical presentation of f-FTLD and give guidance about the psychiatric symptoms that may precede the development of sporadic FTLD, which can then be investigated in future studies.