Sirona - Redefining obesity treatments. A novel hydrogel with long stomach retention times.

**牛津医疗产品公司(OMP)**旨在解决医学界普遍存在的超重问题。超过19亿成年人超重，这是全球第五大生命风险，占全球死亡人数的5%。OMP的愿景是实现安全，有效和负担得起的减肥。OMP由科学家、医疗专业人员和企业家组成的团队领导，他们聚集在一起解决世界上最棘手和最紧迫的挑战之一。OMP的创新产品Sirona**是一种可自我膨胀的水凝胶，它在胃中占据空间，减少饥饿感，从而显著减轻体重。一旦吞下，专利水凝胶的配方为：？在胃里迅速膨胀，导致饱腹感？在胃里停留很长时间，所以它是24小时有效的？分解自然通过，确保安全。OMP的水凝胶被设计成可以在胃部的恶劣环境中保持数周，抑制食欲。然后西罗纳就会崩溃，自然地离开。这些特性创造了一种新颖的、突破性的解决方案，帮助人们实现有意义的减肥。它具有与减肥手术相同的作用模式，减肥手术是目前最有效的治疗方式，但它的设计是负担得起的，并且与没有风险的手术一样有效。在这个项目中，OMP与南安普敦大学医院NHS信托合作，优化和开发用于减肥的Sirona。Sirona提供了显著的社会经济影响，包括显著的医疗保健节省，改善患者的生活质量，减少临床路径对环境的影响，以及改善医疗保健治疗的可及性。这些好处将有助于实现国内和国际政府的议程。英国卫生和社会保障部公布了英国政府的“解决肥胖”战略，制定了解决肥胖问题的议程，帮助成人和儿童过上更健康的生活。

**Oxford Medical Products (OMP)** aims to address the medical pandemic of excessive weight. Over 1.9 billion adults are overweight, it is the fifth biggest risk to life globally, accounting for 5% of global deaths. OMP's vision is to enable safe, effective and affordable weight loss. OMP is led by a team of scientists, medical professionals and entrepreneurs who have come together to solve one of the world's toughest and most urgent challenges.OMP's innovation, **Sirona**, is a self-expanding hydrogel which occupies space in the stomach, reducing hunger, leading to significant weight loss. Once swallowed, the proprietary hydrogel is formulated to:? expand rapidly in the stomach, resulting in a feeling of fullness? stay in the stomach for a prolonged period, so it is effective 24/7? break down and pass naturally, ensuring safety.OMP's hydrogel has been designed to remain in the stomach's harsh environment that suppresses appetite for weeks. Sirona then breaks down and passes naturally.These properties create a novel, breakthrough solution to help people achieve meaningful weight-loss. It has the same mode of action as bariatric surgery, currently the most effective form of treatment, but is designed to be affordable, and as effective as surgery without the risks. In this project, OMP is collaborating with University Hospital Southampton NHS Trust, to optimise and develop Sirona for use in weight-loss.Sirona offers significant socioeconomic impacts including, significant healthcare savings, improving patients' quality of life, reducing the environmental impact of clinical pathways, and improving accessibility to healthcare treatments.These benefits will contribute towards achieving domestic and international governments' agendas. The Department of Health and Social Care published the UK government's 'Tackling Obesity' strategy, setting out the agenda to tackle obesity and help adults and children to live healthier lives.