Linking temporal patterns of modifiable behaviors to weight loss outcomes

项目概要和摘要 这个K 01职业发展奖解决了三个关键的可改变的行为的重要性（身体 活动、能量摄入和睡眠）用于减肥和减肥维持。先前的研究 确定了体力活动（200-300分钟/周）和能量摄入（约1800千卡/天）的绝对量 与体重减轻和维持体重有关。除了身体活动和能量摄入， 流行病学和对照实验室研究表明，睡眠对体重调节很重要; 然而，睡眠在行为减肥干预中的重要性尚未得到评估。这 这项研究将是第一批评估睡眠指数是否与增强对睡眠的依从性有关的研究之一。 在减肥干预和更大的减肥过程中的身体活动和能量摄入处方。 这项研究的发现可能会导致更全面的行为减肥疗法，重点是睡眠 行为以及身体活动和饮食行为。除了身体活动的绝对量之外， 能量摄入和睡眠，新出现的证据表明，时间模式（24小时内的时间， 这些行为的日常一致性）影响减肥结果。总体假设是这样的 应用是这些行为的较早时间（例如，早晨体力活动， 每天、早睡/早起时间）和一致性（每天和工作日到周末）将相关联 更大的体重减轻，更好地坚持饮食和身体活动处方， 减肥干预和减肥维持。识别这些行为的时间模式， 与增强的粘附性和更大的体重减轻相关的，将有助于开发新的，可翻译的， 以及长期减肥的有效行为策略。拟议中的研究计划将促进职业发展 申请人Seth A. Creasy博士在五年内促进了他向独立研究者身份的过渡 K 01的支持一个由多学科、高效率的科学家组成的团队（爱德华·梅兰森博士、维多利亚 Catenacci，Nichole Carlson，Celine Vetter，Valerie Myers）将共同担任Creasy博士的导师。 这项研究在科罗拉多大学安舒茨医学院进行。这个导师团队 专业知识，以培训博士Creasy在身体活动评估方法，双标记水理论和 方法，评估能量摄入，量化时间序列数据的新指标， 开发/实施大型临床减肥干预措施。总之，拟议的培训和专家 指导团队将为Creasy博士提供竞争R 01所需的技能和初步数据 该奖项将作为催化剂，使Creasy博士成为生活方式干预领域的领导者 用于治疗和预防肥胖。

PROJECT SUMMARY & ABSTRACT This K01 Career Development Award addresses the significance of three key modifiable behaviors (physical activity, energy intake, and sleep) for weight loss and weight loss maintenance. Previous investigations have identified that the absolute amounts of physical activity (200-300 min/wk) and energy intake (~1800 kcal/day) are associated with weight loss and weight loss maintenance. In addition to physical activity and energy intake, epidemiological and controlled laboratory studies suggest that sleep is important for bodyweight regulation; however, the importance of sleep during a behavioral weight loss intervention has not yet been evaluated. This study will be one of the first studies to evaluate if indices of sleep are associated with enhanced adherence to physical activity and energy intake prescriptions during a weight loss intervention and greater weight loss. Findings from this study may lead to more comprehensive behavioral weight loss therapies focusing on sleep behavior as well as physical activity and eating behaviors. In addition to the absolute amounts of physical activity, energy intake, and sleep, emerging evidence suggests that temporal patterns (timing across the 24h day and consistency day-to-day) of these behaviors influence weight loss outcomes. The global hypothesis is of this application is that earlier timing of these behaviors (e.g. morning physical activity, eating more calories earlier in the day, earlier bed/ early rise times) and consistency (day-to-day and weekday-to-weekend) will be associated with greater weight loss, better adherence to the diet and physical activity prescriptions during a behavioral weight loss intervention, and weight loss maintenance. Identifying temporal patterns of these behaviors that are associated with enhanced adherence and greater weight loss will aid in the development of novel, translatable, and effective behavioral strategies for long-term weight loss. The proposed research plan will advance the career of the applicant, Seth A. Creasy, PhD facilitating his transition to independent investigator status over the five years of K01 support. A team of highly productive, multidisciplinary scientists (Drs. Edward Melanson, Victoria Catenacci, Nichole Carlson, Celine Vetter, Valerie Myers) will collectively serve as mentors to Dr. Creasy during the proposed research at the University of Colorado – Anschutz Medical Campus. This team of mentors has the expertise to train Dr. Creasy in physical activity assessment methods, doubly labeled water theory and methodology, assessing energy intake, novel metrics for quantifying times-series data, and developing/conducting large, clinical weight loss interventions. In sum, the proposed training and expert mentoring team will provide Dr. Creasy with the skillset and preliminary data necessary to compete for R01 funding, and this award will serve as a catalyst making Dr. Creasy a leader in the field of lifestyle interventions for treating and preventing obesity.