Linking temporal patterns of modifiable behaviors to weight loss outcomes

项目总结与摘要 这个K01职业发展奖阐述了三个关键的可修改行为(物理行为)的重要性 运动、能量摄入和睡眠)来减肥和保持减肥。此前的调查显示 确定体力活动(200-300分钟/周)和能量摄入量(约1800千卡/天)的绝对量 与减肥和减肥维系有关。除了体力活动和能量摄入外， 流行病学和对照实验室研究表明，睡眠对体重调节很重要； 然而，在行为减肥干预过程中睡眠的重要性还没有得到评估。这 这项研究将是评估睡眠指数是否与增强对睡眠的依从性相关的首批研究之一 在减肥干预期间进行体力活动和能量摄入处方，从而达到更好的减肥效果。 这项研究的发现可能会导致更全面的以睡眠为重点的行为减肥疗法 行为以及体力活动和饮食行为。除了体力活动的绝对量， 能量摄入和睡眠，新出现的证据表明，时间模式(24小时一天和 这些行为的日常一致性)会影响减肥结果。全球假说就是这样的 应用是这些行为的更早的时间安排(例如，早上的体力活动，更早地摄入更多的卡路里 一天，早睡/早起时间)和一致性(每天和工作日到周末)将被关联 更好地减肥，更好地遵守饮食和体力活动处方在行为 减肥干预，减肥维系。识别这些行为的时间模式 与更高的粘附性和更大的减肥相关将有助于开发新的、可翻译的、 以及长期减肥的有效行为策略。拟议的研究计划将促进这一事业的发展 申请人，赛斯·A·克雷塞，博士，帮助他在五年内过渡到独立调查员身份 多年的K01支持。一组高效的、多学科的科学家(爱德华·梅兰森博士，维多利亚 Catenacci、Nichole Carlson、Celine Vetter、Valerie Myers)将共同担任克雷西博士的导师 这项研究计划在科罗拉多大学安舒茨医学院进行。这支导师团队拥有 对克雷西博士进行体力活动评估方法、双标记水理论和 方法，评估能量摄入，量化时间序列数据的新指标，以及 开发/实施大规模的临床减肥干预措施。总而言之，拟议的培训和专家 指导团队将为克雷塞博士提供参加R01比赛所需的技能和初步数据 资金，这一奖项将成为催化剂，使克雷塞博士成为生活方式干预领域的领导者 用于治疗和预防肥胖症。

PROJECT SUMMARY & ABSTRACT This K01 Career Development Award addresses the significance of three key modifiable behaviors (physical activity, energy intake, and sleep) for weight loss and weight loss maintenance. Previous investigations have identified that the absolute amounts of physical activity (200-300 min/wk) and energy intake (~1800 kcal/day) are associated with weight loss and weight loss maintenance. In addition to physical activity and energy intake, epidemiological and controlled laboratory studies suggest that sleep is important for bodyweight regulation; however, the importance of sleep during a behavioral weight loss intervention has not yet been evaluated. This study will be one of the first studies to evaluate if indices of sleep are associated with enhanced adherence to physical activity and energy intake prescriptions during a weight loss intervention and greater weight loss. Findings from this study may lead to more comprehensive behavioral weight loss therapies focusing on sleep behavior as well as physical activity and eating behaviors. In addition to the absolute amounts of physical activity, energy intake, and sleep, emerging evidence suggests that temporal patterns (timing across the 24h day and consistency day-to-day) of these behaviors influence weight loss outcomes. The global hypothesis is of this application is that earlier timing of these behaviors (e.g. morning physical activity, eating more calories earlier in the day, earlier bed/ early rise times) and consistency (day-to-day and weekday-to-weekend) will be associated with greater weight loss, better adherence to the diet and physical activity prescriptions during a behavioral weight loss intervention, and weight loss maintenance. Identifying temporal patterns of these behaviors that are associated with enhanced adherence and greater weight loss will aid in the development of novel, translatable, and effective behavioral strategies for long-term weight loss. The proposed research plan will advance the career of the applicant, Seth A. Creasy, PhD facilitating his transition to independent investigator status over the five years of K01 support. A team of highly productive, multidisciplinary scientists (Drs. Edward Melanson, Victoria Catenacci, Nichole Carlson, Celine Vetter, Valerie Myers) will collectively serve as mentors to Dr. Creasy during the proposed research at the University of Colorado – Anschutz Medical Campus. This team of mentors has the expertise to train Dr. Creasy in physical activity assessment methods, doubly labeled water theory and methodology, assessing energy intake, novel metrics for quantifying times-series data, and developing/conducting large, clinical weight loss interventions. In sum, the proposed training and expert mentoring team will provide Dr. Creasy with the skillset and preliminary data necessary to compete for R01 funding, and this award will serve as a catalyst making Dr. Creasy a leader in the field of lifestyle interventions for treating and preventing obesity.