My Healthy Brain: a mindfulness-based lifestyle intervention to modify early risk of dementia in older adults
我的健康大脑:基于正念的生活方式干预,可降低老年人患痴呆症的早期风险
基本信息
- 批准号:10350813
- 负责人:
- 金额:$ 19.28万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-09-15 至 2027-06-30
- 项目状态:未结题
- 来源:
- 关键词:AddressAdherenceAgeAgingAlcoholsAlzheimer disease preventionAlzheimer&aposs disease related dementiaAlzheimer&aposs disease riskAttentionAwardAwarenessBehaviorBehavior TherapyBenchmarkingBrainCardiovascular DiseasesCellular PhoneChronic stressClinicClinicalClinical TrialsCognitionCognitiveComplementDementiaDetectionEducationElderlyElementsEnhancement TechnologyEnvironmentExerciseFeedbackFocus GroupsFundingGeneral HospitalsGoalsGrantHabitsHealthHealth TechnologyHealth behaviorHyperphagiaImpaired cognitionIncidenceIndividualInternationalInterventionInterviewLife ExpectancyLife StyleLinkMassachusettsMedicalMedical StaffMental HealthMentorsMentorshipMethodological StudiesMethodologyMind-Body InterventionModelingMonitorMyristica fragransNeurobehavioral ManifestationsOutcomePalliative CarePatient CarePatient Self-ReportPatientsPeer ReviewPeripheralPersonsPhysiciansPopulationPopulation InterventionPrevalencePreventionProceduresProctor frameworkProviderPsyche structurePsychiatristPsychologistPublicationsPublishingQualitative MethodsResearchResearch PersonnelRiskRisk FactorsScientistServicesSleep DeprivationSmokingTelephone InterviewsTestingTimeTrainingUnhealthy DietWorkacceptability and feasibilityactigraphybasebehavior changebehavioral adherencebiological adaptation to stresscardiovascular risk factorcognitive controlcognitive functioncognitive interviewdementia riskefficacy testingefficacy trialexperienceglobal healthhealth datahealthy aginghealthy lifestylehuman old age (65+)implementation barriersimplementation frameworkimplementation scienceimprovedinterestlifestyle factorslifestyle interventionmHealthmedical schoolsmind controlmindfulnessmindfulness interventionmodifiable lifestyle factorsmultidisciplinarynew technologynovelpatient engagementpersonalized strategiespilot testpreventprimary outcomeprogramsrecruitreinforced behaviorskillssmartphone Applicationsocialstatisticstherapy developmentvirtual
项目摘要
PROJECT SUMMARY
In this K23, I (Dr. Ryan Mace) will acquire training in mindfulness-based lifestyle intervention development for the
prevention of Alzheimer’s Disease and Related Dementias (ADRD). I am a clinical health psychologist at Massachusetts
General Hospital (MGH) and Harvard Medical School, with a strong research background in the cognitive underpinnings
of mental health and aging. My long-term goal is to become an independent investigator and leading developer of
technology-enhanced behavioral interventions, from pilot testing to implementation, for the large-scale promotion of
healthier lifestyles with aging. Through this K23 project, and the rich multidisciplinary training environment at MGH, I
will achieve the following Training Goals: 1) identify implementation barriers using qualitative methods with medical
stakeholders; 2) optimize lifestyle and mindfulness-based interventions for specific aging populations; 3) conduct rigorous
technology-enhanced clinical trials; and 4) collect and analyze mobile health data on lifestyle behavior change. To achieve
these goals, I have assembled an exemplary mentorship team led by my primary mentor, Dr. Ana-Maria Vranceanu, a
clinical health psychologist and a leader in live video mind-body intervention development; co-mentor, Dr. Christine
Ritchie, a geriatrician and palliative care physician with decades of research on improving the detection and treatment of
ADRD; advisor, Dr. Stephen Bartels, a geriatric psychiatrist and national expert in implementation science; advisor, Dr.
Judson Brewer, a psychiatrist and neuroscientist internationally renowned for app-based mindfulness programs for
behavior change; advisor, Dr. Olivia Okereke, a geriatric psychiatrist specializing in modifiable lifestyle risk factors of
ADRD; and advisor, Dr. Bettina Hoeppner, an experimental psychologist with expertise in statistics and longitudinal
modeling of mobile health data. This proposal logically builds on my prior work co-developing My Healthy Brain (MHB)
– the first mindfulness-based lifestyle program to modify ADRD risk factors in older adults with subjective cognitive
decline (SCD). SCD is a critical window for ADRD prevention, while cognitive symptoms are at the earliest stage, yet
prior trials targeting multiple lifestyle factors have shown limited adherence, are time-intensive, and failed to produce
behavior change. In contrast, MHB 1) teaches mindfulness skills to improve lifestyles; 2) uses mobile health technologies
(ActiGraph watches, smartphone app) to assess and reinforce behaviors; and 3) is delivered via live video. For Aim 1, I
will conduct live video focus groups with medical stakeholders (N = 20) using elements from Proctor’s implementation
framework to
address barriers to efficient referrals, develop participant engagement strategies, and optimize study
procedures. For Aim 2, I will establish — via a live video pilot RCT in older adults (age ≥ 60) with SCD and ADRD risk
factors — the feasibility, acceptability, appropriateness, and fidelity of the MHB versus an education control (N=50)
following predetermined benchmarks. The findings will inform an efficacy trial (R01) that will also test mechanisms of
improvements in lifestyle and cognition. This K23 aligns with the NIA funding priority of developing feasible and
personalized strategies for promoting adherence to lifestyles that are protective of ADRD. The experiences gained during
the award will facilitate my independence as a leading clinician scientist focused on healthy aging and ADRD prevention.
项目概要
在这个 K23 中,我(Ryan Mace 博士)将接受基于正念的生活方式干预开发的培训,以帮助
预防阿尔茨海默病和相关痴呆症(ADRD)。我是马萨诸塞州的临床健康心理学家
综合医院 (MGH) 和哈佛医学院,在认知基础方面拥有强大的研究背景
心理健康和老龄化。我的长期目标是成为一名独立调查员和领先的开发人员
技术增强的行为干预措施,从试点测试到实施,以大规模推广
随着年龄的增长,生活方式更加健康。通过这个 K23 项目以及麻省总医院丰富的多学科培训环境,我
将实现以下培训目标:1)使用医学定性方法确定实施障碍
利益相关者; 2)针对特定老龄化人群优化生活方式和基于正念的干预措施; 3)行为严谨
技术增强的临床试验; 4) 收集和分析有关生活方式行为变化的移动健康数据。达到
为了实现这些目标,我组建了一支模范导师团队,由我的主要导师 Ana-Maria Vranceanu 博士领导。
临床健康心理学家和实时视频身心干预开发领域的领导者;共同导师克里斯汀博士
Ritchie 是一位老年病学家和姑息治疗医生,在改善老年痴呆症的检测和治疗方面进行了数十年的研究
ADRD;顾问斯蒂芬·巴特尔斯 (Stephen Bartels) 博士,一位老年精神病学家和国家实施科学专家;顾问,博士
Judson Brewer,一位精神病学家和神经科学家,因基于应用程序的正念项目而享誉国际
行为改变;顾问,Olivia Okereke 博士,一位老年精神病学家,专门研究可改变生活方式的危险因素
ADRD;兼顾问贝蒂娜·霍普纳 (Bettina Hoeppner) 博士是一位实验心理学家,拥有统计学和纵向研究方面的专业知识
移动健康数据建模。该提案在逻辑上建立在我之前共同开发“我的健康大脑”(MHB) 的工作基础上
– 第一个基于正念的生活方式计划,旨在改变具有主观认知的老年人 ADRD 风险因素
下降(SCD)。 SCD是预防ADRD的关键窗口期,而认知症状则处于最早阶段,但
先前针对多种生活方式因素的试验显示,依从性有限、耗时且未能产生效果
行为改变。相比之下,MHB 1) 教授正念技能以改善生活方式; 2)使用移动医疗技术
(ActiGraph 手表、智能手机应用程序)评估和强化行为; 3) 通过实时视频传送。对于目标 1,我
将使用 Proctor 实施中的元素与医疗利益相关者 (N = 20) 进行实时视频焦点小组讨论
框架
解决高效转诊的障碍,制定参与者参与策略并优化研究
程序。对于目标 2,我将通过实时视频试点 RCT,针对患有 SCD 和 ADRD 风险的老年人(年龄 ≥ 60 岁)建立
因素 — MHB 与教育控制的可行性、可接受性、适当性和保真度 (N=50)
遵循预定的基准。研究结果将为功效试验 (R01) 提供信息,该试验也将测试
生活方式和认知的改善。该 K23 与 NIA 的资助优先事项相一致,即开发可行且
促进遵守预防 ADRD 的生活方式的个性化策略。期间获得的经验
该奖项将促进我作为一名专注于健康老龄化和 ADRD 预防的领先临床科学家的独立性。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Ryan Andrew Mace其他文献
Ryan Andrew Mace的其他文献
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{{ truncateString('Ryan Andrew Mace', 18)}}的其他基金
My Healthy Brain: a mindfulness-based lifestyle intervention to modify early risk of dementia in older adults
我的健康大脑:基于正念的生活方式干预,可降低老年人患痴呆症的早期风险
- 批准号:
10700812 - 财政年份:2022
- 资助金额:
$ 19.28万 - 项目类别:
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