Role of type 2 Innate Lymphoid Cells (ILC2s) in optic neuritis

2 型先天淋巴细胞 (ILC2) 在视神经炎中的作用

• 批准号: 10359644
• 负责人: HOMAYON GHIASI
• 金额: $ 3.8万
• 依托单位: CEDARS-SINAI MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-03-01 至 2023-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10359644
• 关键词: Administrative Supplement; Animal Model; Autoimmune Diseases; Cells; Cellular biology; Data; Demyelinations; Environmental Risk Factor; Equipment; Funding; Gases; Grant; Immune; Immune Targeting; Immunotherapy; Inflammatory; Infrastructure; Interleukin-2; Lymphoid Cell; Molecular Biology; Multiple Sclerosis; Optic Nerve; Optic Neuritis; Parents; Request for Proposals; Research; Research Personnel; Research Project Grants; Role; Virus; cost; cryostat; instrument; receptor; repaired

PROJECT SUMMARY This proposal request is an Administrative Supplement to provide Infrastructure Support for an ongoing NEI funded RO1 Research Project. Funding is requested to replace a Leica cryostat that was originally purchased by NEI funds that was supplied to us as an Administrative Supplement. This is a standard use piece of equipment in most molecular and cell biology research labs. Due to leaking of gas the cost of repair will be more than buying a new cryostat. The replacement of this cryostat by the stat-of the-art equipment would greatly enhance our efficiency to successfully carry out all of the aims in the parent RO1 grant. In addition, three other NEI investigators (Drs. Alexander Ljubimov, Mehrnoosh Saghizadeh, and Yaron Rabinowitz) will use this cryostat for their research. Thus, a total of 9 RO1 will be using this instrument for their research.

项目摘要 本提案请求是一份行政补充文件，旨在为正在进行的NEI提供基础设施支持 RO1研究项目。要求提供资金，以更换最初购买的Leica低温恒温器 由NEI资金作为行政补充提供给我们。这是一个标准使用的设备 在大多数分子和细胞生物学研究实验室中。由于煤气泄漏，修理费用将超过 买一个新的低温恒温器用最先进的设备取代这种低温恒温器将大大提高 我们的效率，以成功地实现所有的目标，在母RO1赠款。此外，还有三家 研究人员（亚历山大Ljubimov，Mehrnoosh Saghizadeh和Yaron Rabinowitz博士）将使用该低温恒温器 他们的研究。因此，共有9个区域办事处1将使用该仪器进行研究。