Role of type 2 Innate Lymphoid Cells (ILC2s) in optic neuritis

项目摘要 本提案请求是一份行政补充文件，旨在为正在进行的NEI提供基础设施支持 RO1研究项目。要求提供资金，以更换最初购买的Leica低温恒温器 由NEI基金提供给我们作为行政补充。这是一个标准使用的设备 在大多数分子和细胞生物学研究实验室中。由于煤气泄漏，修理费用将超过 买一个新的低温恒温器用最先进的设备取代低温恒温器将大大提高 我们的效率，以成功地实现所有的目标，在母RO1赠款。此外，还有三家 研究人员（亚历山大Ljubimov，Mehrnoosh Saghizadeh和Yaron Rabinowitz博士）将使用该低温恒温器 他们的研究。因此，共有9个区域办事处1将使用该仪器进行研究。

PROJECT SUMMARY This proposal request is an Administrative Supplement to provide Infrastructure Support for an ongoing NEI funded RO1 Research Project. Funding is requested to replace a Leica cryostat that was originally purchased by NEI funds that was supplied to us as an Administrative Supplement. This is a standard use piece of equipment in most molecular and cell biology research labs. Due to leaking of gas the cost of repair will be more than buying a new cryostat. The replacement of this cryostat by the stat-of the-art equipment would greatly enhance our efficiency to successfully carry out all of the aims in the parent RO1 grant. In addition, three other NEI investigators (Drs. Alexander Ljubimov, Mehrnoosh Saghizadeh, and Yaron Rabinowitz) will use this cryostat for their research. Thus, a total of 9 RO1 will be using this instrument for their research.