Effectiveness of Low-dose Theophylline for the Management of biomass-associated COPD
低剂量茶碱治疗生物质相关慢性阻塞性肺病的有效性
基本信息
- 批准号:10360262
- 负责人:
- 金额:$ 19.66万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-07-15 至 2024-06-30
- 项目状态:已结题
- 来源:
- 关键词:Adrenal Cortex HormonesAdultAgeAgricultural CropsAlbuterolAltitudeAnti-Inflammatory AgentsAttenuatedAwardBenchmarkingBiological MarkersBiomassBiometryBody mass indexBronchodilator AgentsCardiovascular DiseasesCause of DeathCessation of lifeChronicChronic DiseaseChronic Obstructive Airway DiseaseClinical TrialsClinical effectivenessCoalCommunitiesComparative Effectiveness ResearchDataDiabetes MellitusDiseaseDoctor of MedicineDoseDown-RegulationEffectivenessEpidemiologyEvaluationFibrinogenForced expiratory volume functionFrequenciesFundingGenesGenetic TranscriptionGoalsHealthHealth StatusHeatingHistopathologyHourHousehold Air PollutionIncomeIndividualInflammationInflammatoryInhalationInterventionK-Series Research Career ProgramsLung diseasesMeasurementMeasuresMediatingMedicalMentorsMentorshipModelingOutcomeOutcome StudyPathogenesisPeruPeruvianPharmacotherapyPhenotypePlacebosPopulation StudyPrognosisQuality-Adjusted Life YearsQuestionnairesRandomizedRandomized Controlled TrialsRegimenResearchResearch PersonnelRespiratory Signs and SymptomsRisk FactorsScientistSerumTheophyllineTobaccoTrainingUnited States National Institutes of HealthUrbanizationWood materialarmbasebiomass fuelcareercohortcookingcostcost effectivecost effective interventioncost effectivenesscost estimatecost-effectiveness ratioeconomic evaluationeffective therapyeffectiveness evaluationeffectiveness implementation studyeffectiveness testingexperiencefollow-upfunctional disabilitygroup interventionhealth care service utilizationhealth related quality of lifeimprovedincremental cost-effectivenessinstrumentlongitudinal analysislow and middle-income countriesmarkov modelmid-career facultymultidisciplinarypatient oriented researchpilot trialprimary outcomeprofessorpulmonary functionpulmonary function declinerespiratorysexside effectskillssocioeconomicssolid fuelstandard caretreatment responsewastingwillingness to pay
项目摘要
PROJECT SUMMARY/ABSTRACT
This is an application for the K23 Mentored Patient-Oriented Research Career Scientist Award for Trishul
Siddharthan M.D. Dr. Siddharthan has shown great promise as a young investigator, and has experience
conducting research in epidemiology and chronic disease in low- and middle-income countries (LMICs).
However, he is now proposing to gain advanced training in conducting longitudinal analysis and randomized
controlled trials requires additional training and mentorship to do so. His overall career goal is to become an
independent investigator and expert in evaluating the effectiveness medical therapies for chronic respiratory
diseases, and this award will provide Dr. Siddharthan with the support and training to accomplish this goal. He
has assembled an experienced mentorship team including: Dr. William Checkley (Primary Mentor, Chronic
Respiratory Diseases), Associate Professor (JHU); Dr. Robert Wise (Clinical Trials), Professor (JHU); Dr.
James Tonascia (Biostatistics), Professor (JHU); and Dr. David Dowdy (Cost-evaluation), Associate Professor
(JHU). Through a combination of close mentorship, formal coursework, and practical experience, Dr.
Siddharthan proposes to accomplish the following training goals: 1) Advanced training in longitudinal analysis;
2) Advanced training in randomized controlled trials; and 3) Advanced training in cost-evaluation.
Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death worldwide, and over 90%
of COPD-related deaths occurring in low- and middle-income countries (LMICs). Household air pollution (HAP)
– from burning solid fuels such as wood, dung, agricultural crop waste, and coal for energy – is the primary risk
factor for COPD in these settings. Biomass-related COPD has a distinct histopathology, phenotype and
inflammatory profile when compared to tobacco mediated COPD. Despite the high global burden of biomass-
related disease, little is known about the effectiveness of pharmacotherapies for biomass-related COPD; to
date, no clinical trials have focused specifically on treatment of biomass-related COPD. Dr. Siddharthan
proposes to assess the health impact of biomass-related COPD and test the effectiveness of low dose
theophylline compared to standard therapy among adults with biomass-related COPD in Peru. He proposes to
assess whether low-dose theophylline improves respiratory symptoms, decreases the inflammatory profile of
serum biomarkers and whether administration attenuates the effect of HAP on lung function. He additionally
aims to assess whether low-dose theophylline is a cost-effective intervention based on the incremental cost-
effectiveness ratio and a range of willingness to pay thresholds. Results from this study will generate
preliminary data to compete for an R01-level award to conduct an implementation-effectiveness hybrid trial in
multiple communities to assess the impact of chronic pharmacotherapy for biomass-related COPD.
项目总结/摘要
这是Trishul的K23指导以患者为导向的研究职业科学家奖的申请
Siddharthan医学博士Siddharthan博士作为一名年轻的调查员表现出了很大的潜力,
在低收入和中等收入国家开展流行病学和慢性病研究。
然而,他现在建议在进行纵向分析和随机化方面获得高级培训。
对照试验需要额外的培训和指导。他的职业目标是成为一名
独立研究者和专家,评估慢性呼吸道疾病药物治疗的有效性
该奖项将为Siddharthan博士提供支持和培训,以实现这一目标。他
已经组建了一支经验丰富的导师团队,包括:William Checkley博士(初级导师,慢性
呼吸系统疾病),副教授(JHU);博士罗伯特·怀斯(临床试验),教授(JHU);博士。
James Tonascia(生物统计学),教授(JHU);和大卫道迪博士(成本评估),副教授
(JHU)。通过密切的指导,正式的课程和实践经验相结合,博士。
Siddharthan建议完成以下培训目标:1)纵向分析的高级培训;
2)随机对照试验高级培训; 3)成本评估高级培训。
慢性阻塞性肺疾病(COPD)是全球第四大死亡原因,
低收入和中等收入国家(LMIC)中发生的COPD相关死亡。家庭空气污染(HAP)
- 从燃烧固体燃料,如木材,粪便,农作物废料,煤炭能源-是主要的风险
在这些环境中的COPD因素。生物量相关的COPD具有不同的组织病理学、表型和
与烟草介导的COPD相比,尽管全球生物质负担很高-
与生物质相关的疾病,对生物质相关的COPD药物治疗的有效性知之甚少;
迄今为止,没有临床试验专门关注生物质相关COPD的治疗。Siddharthan博士
建议评估生物量相关的COPD对健康的影响,并测试低剂量
在秘鲁,茶碱与标准治疗在患有生物质相关COPD的成人中的比较。他拟
评估低剂量茶碱是否能改善呼吸道症状,降低
血清生物标志物和给药是否减弱HAP对肺功能的影响。他还
旨在评估低剂量茶碱是否是一种基于增量成本的成本效益干预措施-
有效性比率和一系列支付意愿阈值。这项研究的结果将产生
初步数据,以竞争R 01级奖项,在
多个社区评估慢性药物治疗对生物质相关COPD的影响。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Trishul Siddharthan其他文献
Trishul Siddharthan的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Trishul Siddharthan', 18)}}的其他基金
Effectiveness of Low-dose Theophylline for the Management of biomass-associated COPD
低剂量茶碱治疗生物质相关慢性阻塞性肺病的有效性
- 批准号:
10415226 - 财政年份:2019
- 资助金额:
$ 19.66万 - 项目类别:
Effectiveness of Low-dose Theophylline for the Management of Biomass-associated COPD in Peru
秘鲁低剂量茶碱治疗生物质相关慢性阻塞性肺病的有效性
- 批准号:
9978110 - 财政年份:2019
- 资助金额:
$ 19.66万 - 项目类别:
Effectiveness of Low-dose Theophylline for the Management of biomass-associated COPD
低剂量茶碱治疗生物质相关慢性阻塞性肺病的有效性
- 批准号:
10657669 - 财政年份:2019
- 资助金额:
$ 19.66万 - 项目类别:
相似海外基金
Developing a Young Adult-Mediated Intervention to Increase Colorectal Cancer Screening among Rural Screening Age-Eligible Adults
制定年轻人介导的干预措施,以增加农村符合筛查年龄的成年人的结直肠癌筛查
- 批准号:
10653464 - 财政年份:2023
- 资助金额:
$ 19.66万 - 项目类别:
Doctoral Dissertation Research: Estimating adult age-at-death from the pelvis
博士论文研究:从骨盆估算成人死亡年龄
- 批准号:
2316108 - 财政年份:2023
- 资助金额:
$ 19.66万 - 项目类别:
Standard Grant
Determining age dependent factors driving COVID-19 disease severity using experimental human paediatric and adult models of SARS-CoV-2 infection
使用 SARS-CoV-2 感染的实验性人类儿童和成人模型确定导致 COVID-19 疾病严重程度的年龄依赖因素
- 批准号:
BB/V006738/1 - 财政年份:2020
- 资助金额:
$ 19.66万 - 项目类别:
Research Grant
Transplantation of Adult, Tissue-Specific RPE Stem Cells for Non-exudative Age-related macular degeneration (AMD)
成人组织特异性 RPE 干细胞移植治疗非渗出性年龄相关性黄斑变性 (AMD)
- 批准号:
10294664 - 财政年份:2020
- 资助金额:
$ 19.66万 - 项目类别:
Sex differences in the effect of age on episodic memory-related brain function across the adult lifespan
年龄对成人一生中情景记忆相关脑功能影响的性别差异
- 批准号:
422882 - 财政年份:2019
- 资助金额:
$ 19.66万 - 项目类别:
Operating Grants
Modelling Age- and Sex-related Changes in Gait Coordination Strategies in a Healthy Adult Population Using Principal Component Analysis
使用主成分分析对健康成年人群步态协调策略中与年龄和性别相关的变化进行建模
- 批准号:
430871 - 财政年份:2019
- 资助金额:
$ 19.66万 - 项目类别:
Studentship Programs
Transplantation of Adult, Tissue-Specific RPE Stem Cells as Therapy for Non-exudative Age-Related Macular Degeneration AMD
成人组织特异性 RPE 干细胞移植治疗非渗出性年龄相关性黄斑变性 AMD
- 批准号:
9811094 - 财政年份:2019
- 资助金额:
$ 19.66万 - 项目类别:
Study of pathogenic mechanism of age-dependent chromosome translocation in adult acute lymphoblastic leukemia
成人急性淋巴细胞白血病年龄依赖性染色体易位发病机制研究
- 批准号:
18K16103 - 财政年份:2018
- 资助金额:
$ 19.66万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Doctoral Dissertation Research: Literacy Effects on Language Acquisition and Sentence Processing in Adult L1 and School-Age Heritage Speakers of Spanish
博士论文研究:识字对西班牙语成人母语和学龄传统使用者语言习得和句子处理的影响
- 批准号:
1823881 - 财政年份:2018
- 资助金额:
$ 19.66万 - 项目类别:
Standard Grant
Adult Age-differences in Auditory Selective Attention: The Interplay of Norepinephrine and Rhythmic Neural Activity
成人听觉选择性注意的年龄差异:去甲肾上腺素与节律神经活动的相互作用
- 批准号:
369385245 - 财政年份:2017
- 资助金额:
$ 19.66万 - 项目类别:
Research Grants