Hosted Commercial In-Life Data Collection and Management System for the National Toxicology Program (Subproject 2 Support for Prevention Research by NTP)

主持国家毒理学计划的商业生命数据收集和管理系统（国家毒理学计划预防研究子项目2支持）

• 批准号: 10361168
• 负责人: DAVID WHEELER
• 金额: $ 25.2万
• 依托单位: INSTEM LSS (NORTH AMERICA) LIMITED
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-03-01 至 2022-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10361168
• 关键词: Amendment; Back; Contracts; Data; Data Collection; Data Management Resources; Data Reporting; Databases; Development; Environment; Human; Institutes; Internet; Laboratories; Laboratory Personnel; Laboratory Study; Life; Management Information Systems; Markov Chains; Mission; Modernization; Molecular Biology; Monitor; National Institute of Environmental Health Sciences; National Toxicology Program; Pathologist; Pathology; Pathology Report; Prevention Research; Public Health; Reporting; Research; Research Design; Role; Running; Science; Scientist; Secure; System; Testing; Toxicology; United States Dept. of Health and Human Services; United States National Institutes of Health; base; carcinogenicity; central database; design; developmental toxicity; disability; environmental agent; environmental chemical; human disease; new technology; programs; reproductive toxicity; tool

The National Institute of Environmental Health Sciences (NIEHS) is one of 27 Institutes and Centers of the National Institutes of Health (NIH), Department of Health and Human Services (DHHS). The mission of the NIEHS is to reduce the burden of human illness and disability by understanding how the environment influences the development and progression of human disease. The Division of the National Toxicology Program (NTP) is an interagency program whose mission is to evaluate agents of public health concern by developing and applying tools of modern toxicology and molecular biology. The NTP maintains an objective, science-based approach in dealing with critical issues in toxicology and is committed to using the best science available to prioritize, design, conduct, and interpret its studies. To that end, the NTP is continually evolving to remain at the cutting edge of scientific research and to develop and apply new technologies. In carrying out its mission, the NTP studies the effects of environmental agents in laboratory studies, which are performed predominantly at contract laboratories and then reviewed by the NTP. The NTP requires a hosted data management system to collect data from multiple laboratories and host the data in a secure central database which the NTP scientists can access in order to review and analyze the data. The system shall use the internet to transmit the collected data securely back to the hosted database. This system shall meet requirements for use in a GLP-regulated environment. DNTP selected Provantis LIMS hosted by Instem as the system to use for this purpose.

国家环境健康科学研究所（NIEHS）是美国国立卫生研究院（NIH），卫生与人类服务部（DHHS）的27个研究所和中心之一。 NIEHS的使命是通过了解环境如何影响人类疾病的发展和进展来减轻人类疾病和残疾的负担。 国家毒理学规划司（NTP）是一个机构间规划，其使命是通过开发和应用现代毒理学和分子生物学工具来评估公共卫生关注的物质。NTP在处理毒理学中的关键问题时保持客观，基于科学的方法，并致力于使用现有的最佳科学来优先考虑，设计，实施和解释其研究。为此，NTP不断发展，以保持在科学研究的前沿，并开发和应用新技术。 在执行其使命时，国家毒物管理局在实验室研究中研究环境物剂的影响，这些研究主要在合同实验室进行，然后由国家毒物管理局进行审查。 NTP需要一个托管的数据管理系统来收集来自多个实验室的数据，并将数据托管在一个安全的中央数据库中，NTP科学家可以访问该数据库，以便审查和分析数据。 系统应使用互联网将收集的数据安全地传输回托管数据库。 该系统应满足GLP监管环境中的使用要求。 DNTP选择由Instem托管的Provantis LIMS作为用于此目的的系统。