The role of executive functions in reading and reading remediation

执行功能在阅读和阅读补救中的作用

• 批准号: 10573506
• 负责人: Tzipi Horowitz-Kraus
• 金额: $ 5.13万
• 依托单位: HUGO W. MOSER RES INST KENNEDY KRIEGER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-11-01 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10573506
• 关键词: role; executive; functions; reading; remediation

 DESCRIPTION (provided by applicant): Reading difficulty is characterized by slow, inaccurate reading, poor comprehension and fluency. The goal of this proposal is to demonstrate that executive functions also have a crucial role in proficient reading. Specifically we will examine two novel hypotheses about the role of executive functions in reading using brain imaging and behavioral assessments of reading and executive functions skills in children. First, we postulate that poor reading skills will be associated with disruption in connectivity between executive functions and reading networks as reflected in neuroimaging measures of structural and functional connectivity. Secondly, we expect that computer-based training using the Reading Acceleration Program (RAP) will improve reading by strengthening connections between reading and executive functions circuitry. We anticipate an improvement in reading skills in both typical readers and children with reading difficulties, with more specific and dramatic impact on reading abilities in children with reading difficulties. Our pilot data has demonstrated that RAP training improved reading as well executive functions in children with reading difficulties in as little as four weeks. The proposed studies will use structural and functional brain imaging and connectivity analysis plus reading and cognitive assessments to fill the gap in our knowledge about the interaction between executive functions and reading ability. Further, a control group with a non-reading intervention will allow us to examine the specificity o the RAP intervention to reading difficulties. We will apply this knowledge to determine whether executive functions-based reading intervention, targeting the connection between executive functions and reading, can remediate reading difficulties in school age children. We will apply innovative analysis methods to understand the role of executive functions in reading aimed at developing more suitable diagnoses and interventions for children with reading difficulties.

 描述（申请人提供）：阅读困难的特点是阅读缓慢、不准确、理解力和流畅性较差。该提案的目标是证明执行功能在熟练阅读中也发挥着至关重要的作用。具体来说，我们将使用大脑成像和对儿童阅读和执行功能技能的行为评估来研究关于执行功能在阅读中的作用的两个新假设。首先，我们假设阅读技能差将与执行功能和阅读网络之间的连接中断有关，这反映在结构和功能连接的神经影像测量中。其次，我们期望使用阅读加速计划（RAP）的基于计算机的培训将通过加强阅读和执行功能电路之间的联系来提高阅读能力。我们预计普通读者和有阅读困难的儿童的阅读技能都会得到改善，并对有阅读困难的儿童的阅读能力产生更具体和显着的影响。我们的试点数据表明，RAP 训练在短短四个星期内就改善了有阅读困难的儿童的阅读能力和执行功能。拟议的研究将使用结构和功能脑成像和连通性分析以及阅读和认知评估来填补我们关于执行功能和阅读能力之间相互作用的知识空白。此外，采用非阅读干预的对照组将使我们能够检查 RAP 干预对阅读困难的特异性。我们将应用这些知识来确定基于执行功能的阅读干预（针对执行功能与阅读之间的联系）是否可以纠正学龄儿童的阅读困难。我们将应用创新的分析方法来了解执行功能在阅读中的作用，旨在为阅读困难的儿童制定更合适的诊断和干预措施。

项目成果

The role of visual attention in dyslexia: Behavioral and neurobiological evidence.

• DOI: 10.1002/hbm.25753
• 发表时间: 2022-04-01
• 期刊: Human brain mapping
• 影响因子: 4.8
• 作者: Taran N;Farah R;DiFrancesco M;Altaye M;Vannest J;Holland S;Rosch K;Schlaggar BL;Horowitz-Kraus T
• 通讯作者: Horowitz-Kraus T

Cognitive and emotional challenges in children with reading difficulties.

有阅读困难的儿童的认知和情感挑战。

• DOI: 10.1111/apa.14672
• 发表时间: 2019
• 期刊: Acta paediatrica (Oslo, Norway : 1992)
• 作者: Nachshon,Ohad;Horowitz-Kraus,Tzipi
• 通讯作者: Horowitz-Kraus,Tzipi

Decreased functional connectivity of the salience network during narrative comprehension in children with reading difficulties: An fMRI study.

• DOI: 10.1016/j.nicl.2018.10.006
• 发表时间: 2018
• 期刊: NeuroImage. Clinical
• 作者: Twait E;Farah R;Horowitz-Kraus T
• 通讯作者: Horowitz-Kraus T

Functional Connectivity of Cognitive Control and Visual Regions During Verb Generation Is Related to Improved Reading in Children.

动词生成过程中认知控制和视觉区域的功能连接与儿童阅读能力的提高有关。

• DOI: 10.1089/brain.2018.0655
• 发表时间: 2019
• 期刊: Brain connectivity
• 影响因子: 3.4
• 作者: Twait,Emma;Horowitz-Kraus,Tzipi
• 通讯作者: Horowitz-Kraus,Tzipi

Maternal education as an environmental factor related to reading in children with reading difficulties: A functional magnetic resonance imaging study.

母亲教育作为与阅读困难儿童阅读相关的环境因素：一项功能性磁共振成像研究。

• DOI: 10.1002/dys.1744
• 发表时间: 2023
• 期刊: Dyslexia (Chichester, England)
• 作者: Greenwood,Paige;Hutton,John;Dudley,Jonathan;DiFrancesco,Mark;Farah,Rola;Altaye,Mekibib;Horowitz-Kraus,Tzipi
• 通讯作者: Horowitz-Kraus,Tzipi