HEALing LB3P: Profiling Biomechanical, Biological and Behavioral phenotypes
HEALing LB3P:分析生物力学、生物和行为表型
基本信息
- 批准号:10765804
- 负责人:
- 金额:$ 39.62万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-09-26 至 2024-08-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
ABSTRACT
The purpose of the University of Pittsburgh Low Back Pain: Biological, Biomechanical, Behavioral Phenotypes
(LB3P) Mechanistic Research Center is to perform in-depth phenotyping of patients with chronic low back pain
(CLBP), using a multi-modal approach, to characterize patients and provide insight into the phenotypes
associated with experience of CLBP to direct targeted and improved treatments. This new center will uniquely
address the critical challenge facing care for patients with CLBP, which is the rising costs of care related to
failed treatments, and resultant loss of quality of life and function with increasing reliance on opioid use resulting
from our inability to properly select patients for properly targeted treatments with a high likelihood of
success. The LB3P MRC will be formed of three Research Cores, which will be primarily responsible for data
collection and analysis of the three key contributors to CLBP (Biological, Biomechanical, and Behavioral);
three support cores primarily responsible for data organization, processing, storage and dissemination, including
interactions with the BACPAC (Administrative, Clinical, and Informatics); and one Research Project (deep
phenotyping of CLBP patient characteristics and response to treatments), serving to leverage all of the services
and products of the individual cores into the development of a unique clinical set of phenotypes associated with
response to treatment to guide properly targeted, individualized future care models for CLBP. This approach
will leverage and integrate distinctive resources at the University of Pittsburgh laboratories to deliver quantified
biomechanical, biological, and behavioral characteristics, functional assessments and patient-reported
outcomes, coupled with advanced data analytics using a novel Network Phenotyping Strategy (NPS). A
comprehensive and integrated biopsychosocial approach will be employed, which is necessary to improve
treatment for this complex and multi-dimensional condition. It is critical that the interaction of individual
variables is maintained in any phenotyping strategy, since in the syndrome of CLBP there is significant
interaction of each contributor, and this is an important strength of the proposed approach. The formation of this
center will build upon existing strengths within the University of Pittsburgh research community and focus efforts
around the critical challenge of CLBP, and the collaborative approach will serve as an important resource for the
BACPAC community. The LB3P MRC will coordinate the interdisciplinary expertise of clinicians and researchers
to study the contributors and predictors of CLBP, and to propose a culminating research project that promises
to translate the findings to clinical utilization and change the paradigm of care for CLBP. The proposed approach,
by eliminating isolated and disconnected approaches to treatment, and instead focusing on personalized patient-
centric approaches, will yield improved outcomes and patient satisfaction. In addition, the robust environment,
including an academic medical center with an integrated care delivery and finance system, will ensure rapid and
efficient translation of the results into novel care models for CLBP patients.
摘要
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
NAM V VO其他文献
NAM V VO的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('NAM V VO', 18)}}的其他基金
Mechanisms of Cellular Senescence Driving Intervertebral Disc Aging through Local Cell Autonomous and Systemic Non-Cell Autonomous Processes
细胞衰老通过局部细胞自主和全身非细胞自主过程驱动椎间盘老化的机制
- 批准号:
10635092 - 财政年份:2023
- 资助金额:
$ 39.62万 - 项目类别:
HEALing LB3P: Profiling Biomechanical, Biological and Behavioral phenotypes
HEALing LB3P:分析生物力学、生物和行为表型
- 批准号:
9897965 - 财政年份:2019
- 资助金额:
$ 39.62万 - 项目类别:
The role of cellular senescence in intervertebral disc aging
细胞衰老在椎间盘老化中的作用
- 批准号:
8478298 - 财政年份:2013
- 资助金额:
$ 39.62万 - 项目类别:
The role of cellular senescence in intervertebral disc aging
细胞衰老在椎间盘老化中的作用
- 批准号:
9267403 - 财政年份:2013
- 资助金额:
$ 39.62万 - 项目类别:
MECHANISM OF DISC PROTEOGLYCAN LOSS IN A MOUSE MODEL OF ACCELERATED AGING
加速衰老小鼠模型中椎间盘蛋白聚糖丢失的机制
- 批准号:
7988883 - 财政年份:2010
- 资助金额:
$ 39.62万 - 项目类别:
MECHANISM OF DISC PROTEOGLYCAN LOSS IN A MOUSE MODEL OF ACCELERATED AGING
加速衰老小鼠模型中椎间盘蛋白聚糖丢失的机制
- 批准号:
8128658 - 财政年份:2010
- 资助金额:
$ 39.62万 - 项目类别:
相似海外基金
HEALing LB3P: Profiling Biomechanical, Biological and Behavioral phenotypes
HEALing LB3P:分析生物力学、生物和行为表型
- 批准号:
10415626 - 财政年份:2021
- 资助金额:
$ 39.62万 - 项目类别:
HEALing LB3P: Profiling Biomechanical, Biological and Behavioral phenotypes
HEALing LB3P:分析生物力学、生物和行为表型
- 批准号:
10406064 - 财政年份:2021
- 资助金额:
$ 39.62万 - 项目类别:
HEALing LB3P: Profiling Biomechanical, Biological and Behavioral phenotypes
HEALing LB3P:分析生物力学、生物和行为表型
- 批准号:
9897967 - 财政年份:2019
- 资助金额:
$ 39.62万 - 项目类别:
HEALing LB3P: Profiling Biomechanical, Biological and Behavioral phenotypes
HEALing LB3P:分析生物力学、生物和行为表型
- 批准号:
10765802 - 财政年份:2019
- 资助金额:
$ 39.62万 - 项目类别:
HEALing LB3P: Profiling Biomechanical, Biological and Behavioral phenotypes
HEALing LB3P:分析生物力学、生物和行为表型
- 批准号:
10765805 - 财政年份:2019
- 资助金额:
$ 39.62万 - 项目类别:
HEALing LB3P: Profiling Biomechanical, Biological and Behavioral phenotypes
HEALing LB3P:分析生物力学、生物和行为表型
- 批准号:
9897966 - 财政年份:2019
- 资助金额:
$ 39.62万 - 项目类别:
HEALing LB3P: Profiling Biomechanical, Biological and Behavioral phenotypes
HEALing LB3P:分析生物力学、生物和行为表型
- 批准号:
10765809 - 财政年份:2019
- 资助金额:
$ 39.62万 - 项目类别:
HEALing LB3P: Profiling Biomechanical, Biological and Behavioral phenotypes
HEALing LB3P:分析生物力学、生物和行为表型
- 批准号:
9897962 - 财政年份:2019
- 资助金额:
$ 39.62万 - 项目类别:
HEALing LB3P: Profiling Biomechanical, Biological and Behavioral phenotypes
HEALing LB3P:分析生物力学、生物和行为表型
- 批准号:
9897968 - 财政年份:2019
- 资助金额:
$ 39.62万 - 项目类别:
HEALing LB3P: Profiling Biomechanical, Biological and Behavioral phenotypes
HEALing LB3P:分析生物力学、生物和行为表型
- 批准号:
10765806 - 财政年份:2019
- 资助金额:
$ 39.62万 - 项目类别: