HEALing LB3P: Profiling Biomechanical, Biological and Behavioral phenotypes

HEALing LB3P:分析生物力学、生物和行为表型

基本信息

  • 批准号:
    9897965
  • 负责人:
  • 金额:
    $ 455.1万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2019
  • 资助国家:
    美国
  • 起止时间:
    2019-09-26 至 2023-08-31
  • 项目状态:
    已结题

项目摘要

ABSTRACT The purpose of the University of Pittsburgh Low Back Pain: Biological, Biomechanical, Behavioral Phenotypes (LB3P) Mechanistic Research Center is to perform in-depth phenotyping of patients with chronic low back pain (CLBP), using a multi-modal approach, to characterize patients and provide insight into the phenotypes associated with experience of CLBP to direct targeted and improved treatments. This new center will uniquely address the critical challenge facing care for patients with CLBP, which is the rising costs of care related to failed treatments, and resultant loss of quality of life and function with increasing reliance on opioid use resulting from our inability to properly select patients for properly targeted treatments with a high likelihood of success. The LB3P MRC will be formed of three Research Cores, which will be primarily responsible for data collection and analysis of the three key contributors to CLBP (Biological, Biomechanical, and Behavioral); three support cores primarily responsible for data organization, processing, storage and dissemination, including interactions with the BACPAC (Administrative, Clinical, and Informatics); and one Research Project (deep phenotyping of CLBP patient characteristics and response to treatments), serving to leverage all of the services and products of the individual cores into the development of a unique clinical set of phenotypes associated with response to treatment to guide properly targeted, individualized future care models for CLBP. This approach will leverage and integrate distinctive resources at the University of Pittsburgh laboratories to deliver quantified biomechanical, biological, and behavioral characteristics, functional assessments and patient-reported outcomes, coupled with advanced data analytics using a novel Network Phenotyping Strategy (NPS). A comprehensive and integrated biopsychosocial approach will be employed, which is necessary to improve treatment for this complex and multi-dimensional condition. It is critical that the interaction of individual variables is maintained in any phenotyping strategy, since in the syndrome of CLBP there is significant interaction of each contributor, and this is an important strength of the proposed approach. The formation of this center will build upon existing strengths within the University of Pittsburgh research community and focus efforts around the critical challenge of CLBP, and the collaborative approach will serve as an important resource for the BACPAC community. The LB3P MRC will coordinate the interdisciplinary expertise of clinicians and researchers to study the contributors and predictors of CLBP, and to propose a culminating research project that promises to translate the findings to clinical utilization and change the paradigm of care for CLBP. The proposed approach, by eliminating isolated and disconnected approaches to treatment, and instead focusing on personalized patient- centric approaches, will yield improved outcomes and patient satisfaction. In addition, the robust environment, including an academic medical center with an integrated care delivery and finance system, will ensure rapid and efficient translation of the results into novel care models for CLBP patients.
摘要 匹兹堡大学腰痛的目的:生物学、生物力学和行为表型 (LB3P)机制研究中心将对慢性下腰痛患者进行深入的表型鉴定 (CLBP),使用多模式方法来描述患者的特征并提供对表型的洞察 结合CLBP治疗经验,指导针对性和改进治疗。这个新中心将是独一无二的 应对CLBP患者护理面临的重大挑战,即与以下相关的不断上升的护理成本 治疗失败,导致生活质量和功能丧失,并日益依赖阿片类药物的使用 因为我们无法正确地选择患者进行适当的靶向治疗,这种治疗很有可能 成功。LB3P MRC将由三个研究核心组成,这些核心将主要负责数据 收集和分析导致CLBP的三个关键因素(生物、生物力学和行为); 主要负责数据组织、处理、存储和传播的三个支助核心,包括 与BACPAC的互动(管理、临床和信息学);和一个研究项目(深度 CLBP患者特征和治疗反应的表型),服务于利用所有服务 和产品的个别核心发展成一套独特的临床表型与 对治疗作出反应,指导CLBP有针对性的、个性化的未来护理模式。这种方法 将利用和整合匹兹堡大学实验室的独特资源来提供量化的 生物力学、生物学和行为特征、功能评估和患者报告 结果,结合使用新的网络表型策略(NPS)的高级数据分析。一个 将采用全面和综合的生物-心理-社会方法,这是改善 治疗这种复杂和多维的疾病。至关重要的是,个人之间的互动 变量被保留在任何表型策略中,因为在CLBP综合征中有显著的 每个贡献者的互动,这是提议的方法的一个重要优势。这一现象的形成 中心将在匹兹堡大学研究社区内现有优势的基础上,专注于努力 围绕CLBP的关键挑战,协作方法将成为 巴克帕克社区。LB3P MRC将协调临床医生和研究人员的跨学科专业知识 研究CLBP的贡献者和预测者,并提出一个最终的研究项目,承诺 将这一发现转化为临床应用,并改变CLBP的护理模式。建议的方法是, 通过消除孤立和脱节的治疗方法,转而关注个性化的患者- 以人为本的方法,将产生更好的结果和患者满意度。此外,稳健的环境, 包括一个具有综合护理提供和财务系统的学术医疗中心,将确保快速和 有效地将结果转化为CLBP患者的新护理模式。

项目成果

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{{ truncateString('NAM V VO', 18)}}的其他基金

Mechanisms of Cellular Senescence Driving Intervertebral Disc Aging through Local Cell Autonomous and Systemic Non-Cell Autonomous Processes
细胞衰老通过局部细胞自主和全身非细胞自主过程驱动椎间盘老化的机制
  • 批准号:
    10635092
  • 财政年份:
    2023
  • 资助金额:
    $ 455.1万
  • 项目类别:
HEALing LB3P: Profiling Biomechanical, Biological and Behavioral phenotypes
HEALing LB3P:分析生物力学、生物和行为表型
  • 批准号:
    10765804
  • 财政年份:
    2019
  • 资助金额:
    $ 455.1万
  • 项目类别:
The role of cellular senescence in intervertebral disc aging
细胞衰老在椎间盘老化中的作用
  • 批准号:
    8478298
  • 财政年份:
    2013
  • 资助金额:
    $ 455.1万
  • 项目类别:
The role of cellular senescence in intervertebral disc aging
细胞衰老在椎间盘老化中的作用
  • 批准号:
    9267403
  • 财政年份:
    2013
  • 资助金额:
    $ 455.1万
  • 项目类别:
MECHANISM OF DISC PROTEOGLYCAN LOSS IN A MOUSE MODEL OF ACCELERATED AGING
加速衰老小鼠模型中椎间盘蛋白聚糖丢失的机制
  • 批准号:
    7988883
  • 财政年份:
    2010
  • 资助金额:
    $ 455.1万
  • 项目类别:
MECHANISM OF DISC PROTEOGLYCAN LOSS IN A MOUSE MODEL OF ACCELERATED AGING
加速衰老小鼠模型中椎间盘蛋白聚糖丢失的机制
  • 批准号:
    8128658
  • 财政年份:
    2010
  • 资助金额:
    $ 455.1万
  • 项目类别:

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