Physical Function/Biomechanics Core

物理功能和生物力学(PFB)核心将提供一套工具来帮助描述 腰痛的功能和生物力学表型。我们团队提供的跨区感知工具 模式包括全身运动跟踪、高保真脊椎跟踪和不显眼的活动监控。 这些方法可供患者使用，对照黄金标准方法进行验证，并已 被认为在脊柱健康领域有影响力的。这些工具已经显示出预测背痛的潜力。 风险，评估整个康复过程中的功能，并提供与身体功能和 生物力学。此外，PFB核心整合了一项技术发展计划，将优化我们的工具 对加州大学旧金山分校初步结果确定的关键功能和生物力学表型的反应 Reach Research Project。我们还建议开发一种评估功能和生物力学的方法。 使用传感器和真实世界数据从患者在诊所外的活动中获得表型。 PFB核心的服务将提供必要的研究设计输入、硬件/设备、后处理 分析和数据解释，以向加州大学洛杉矶分校REACH和更大的BACPAC提供结果数据 财团。PFB核心将支持跨越从工作台到床边的连续统的研究，提供独特的 生物力学运动和功能评估的工具，并鼓励基础、 翻译和临床研究人员。通过这种方法，我们将解决基本问题和 培养更完整的背痛模型的翻译项目，加深我们对疾病的理解 对治疗作出反应的途径和基础以及提高有效治疗和干预措施的针对性 对个别病人来说。

The Physical Function and Biomechanics (PFB) Core will provide a suite of tools to aid in characterizing functional and biomechanical phenotypes of low back pain. The tools provided by our team span sensing modalities ranging from full body motion tracking, high fidelity spine tracking, and unobtrusive activity monitoring. These methods are scalable for patient use, are validated against gold-standard methods, and have been deemed influential within the field of spinal health. These tools have demonstrated potential to predict back pain risk, assess function throughout recovery, and provide objective outcomes in relation to physical function and biomechanics. In addition, the PFB Core incorporates a technology evolution plan that will optimize our tools in response to key functional and biomechanical phenotypes identified from preliminary results from the UCSF REACH Research Project. We also propose developing a method to assess functional and biomechanical phenotypes from patient activity outside of the clinic using sensors and real-world data. Services from the PFB Core will provide the necessary study design input, hardware/devices, post-processing analyses, and data interpretation to deliver outcomes data to both UCSF REACH and the greater BACPAC Consortium. The PFB Core will support research spanning the bench-to-bedside continuum, providing unique tools in biomechanical motion and functional evaluation, and encouraging collaborations between basic, translational, and clinical researchers. Through this approach, we will address both fundamental questions and translational projects that cultivate a more integrated model of back pain, further our understanding of disease pathways and the basis for response to treatments and improve targeting of effective therapies and interventions to individual patients.