Physical Function/Biomechanics Core

身体功能和生物力学（PFB）核心将提供一套工具，以帮助表征 下背痛的功能和生物力学表型。我们的团队提供的工具跨越了传感 模态的范围从全身运动跟踪、高保真脊柱跟踪和不显眼的活动监视。 这些方法是可扩展的患者使用，验证金标准的方法，并已 在脊柱健康领域有影响力。这些工具已经证明了预测背痛的潜力 风险，评估整个恢复过程中的功能，并提供与身体功能有关的客观结果， 生物力学此外，PFB Core还整合了一项技术演进计划，将优化我们的工具， 对UCSF初步结果中确定的关键功能和生物力学表型的反应 REACH研究项目。我们还建议开发一种方法来评估功能和生物力学 使用传感器和真实世界的数据从患者在诊所外的活动中获得表型。 PFB核心的服务将提供必要的研究设计输入、硬件/器械、后处理 分析和数据解释，以向UCSF REACH和更大的BACPAC提供结果数据 财团PFB核心将支持从实验室到床边的连续研究， 生物力学运动和功能评估工具，并鼓励基础， 翻译和临床研究人员。通过这种方法，我们将解决两个基本问题， 翻译项目，培养一个更完整的背部疼痛模型，进一步我们对疾病的理解， 治疗反应的途径和基础，并改进有效治疗和干预措施的靶向 对个别患者。

The Physical Function and Biomechanics (PFB) Core will provide a suite of tools to aid in characterizing functional and biomechanical phenotypes of low back pain. The tools provided by our team span sensing modalities ranging from full body motion tracking, high fidelity spine tracking, and unobtrusive activity monitoring. These methods are scalable for patient use, are validated against gold-standard methods, and have been deemed influential within the field of spinal health. These tools have demonstrated potential to predict back pain risk, assess function throughout recovery, and provide objective outcomes in relation to physical function and biomechanics. In addition, the PFB Core incorporates a technology evolution plan that will optimize our tools in response to key functional and biomechanical phenotypes identified from preliminary results from the UCSF REACH Research Project. We also propose developing a method to assess functional and biomechanical phenotypes from patient activity outside of the clinic using sensors and real-world data. Services from the PFB Core will provide the necessary study design input, hardware/devices, post-processing analyses, and data interpretation to deliver outcomes data to both UCSF REACH and the greater BACPAC Consortium. The PFB Core will support research spanning the bench-to-bedside continuum, providing unique tools in biomechanical motion and functional evaluation, and encouraging collaborations between basic, translational, and clinical researchers. Through this approach, we will address both fundamental questions and translational projects that cultivate a more integrated model of back pain, further our understanding of disease pathways and the basis for response to treatments and improve targeting of effective therapies and interventions to individual patients.