BlueTools - INNOVATIVE TOOLS FOR SUSTAINABLE EXPLORATION OF MARINE MICROBIOMINNOVATIVE TOOLS FOR SUSTAINABLE EXPLORATION OF MARINE MICROBIOMES: TOWARDS A CIRCULAR BLUE BIOECONOMY AND HEALTHIER MARINE ENVIRONMENTS

BlueTools - 海洋微生物可持续探索的创新工具 海洋微生物可持续探索的创新工具：迈向循环蓝色生物经济和更健康的海洋环境

• 批准号: 10055544
• 金额: $ 57.1万
• 依托单位: PROZOMIX LIMITED
• 依托单位国家: 英国
• 项目类别: EU-Funded
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=10055544
• 关键词: BlueTools; INNOVATIVE; TOOLS; SUSTAINABLE; EXPLORATION

Marine microbiomes represent 90% of the total living marine biomass but only a small fraction of them can be cultivated. For this reason,they are an underexplored source of bioactive compounds, carbohydrate polymers and proteins, among others. Sampling the marinebiodiversity, screening, identifying and isolating the relevant microbes is cumbersome, expensive and results in a heavy environmentalburden, low yields, high costs and long times to market. Therefore, new approaches are necessary to overcome the limitations for thestudy of marine microbial communities and their “econological use”. BLUETOOLS will unravel the potential of marine microbiomesfor healthier oceans and the Blue Bioeconomy through integration of different fields to develop cutting-edge tools that support fast,efficient AND sustainable exploration and exploitation of microbiomes, avoiding the drawbacks of conventional biodiscovery practices.The expected results of BLUETOOLS include discovering several hundreds of enzymes, rhodopsins, resistance genes, antimicrobialsand anti-microfouling agents, thanks to a hybrid workflow of in silico and microfluidics-based functional discovery, resulting in thecommercialization =400 enzymes for biocatalysis and =2 new solutions for plastic/polymer degradation, increasing the revenue of ourindustrial partners by 10-15%. BLUETOOLS assembles 5 leading European companies, 8 academic teams and 1 private RTO that havepioneered approaches in functional metagenomics, microfluidics, microbial ecology and synthetic biology. The presence of diverse,complementary industrial stakeholders in the consortium (from pharma to materials science to sustainability) at different stages in theresearch-to-market process (from RTOs to SMEs to large end-users) provides a unique opportunity for broad value creation. The plannedactivities will span 48 months and the project is estimated at ca. 9 M€, with 60% of the total dedicated to creating highly-qualified jobs

海洋微生物组占活着的海洋生物量的90％，但只能培养其中一小部分。因此，它们是生物活性化合物，碳水化合物聚合物和蛋白质等无流动的来源。对海洋生物多样性进行采样，筛查，识别和隔离相关的微生物很麻烦，昂贵，并且会带来沉重的环境负担，低收益，高成本和长时间的市场。因此，必须采用新的方法来克服研究海洋微生物组及其“生态学使用”的局限性。通过整合不同领域的蓝色生物学因素，蓝eTools将阐明海洋微生物因子对更健康的海洋和蓝色的生物经济的潜力抗菌剂和抗微燃料剂，感谢您在硅和基于微流体的功能发现的混合工作流程，从而导致商业化= 400个生物催化的酶，并= 2种塑料/聚合物降解的新解决方案，从而增加了Our Inderublial partners a Our Inderublial partners乘10-15％。 Bluetools组装了5家领先的欧洲公司，8个学术团队和1个私人RTO，这些公司在功能性宏基因组学，微流体，微生物生态学和合成生物学方面采用了方法。在搜索到市场流程的不同阶段（从RTOS到SME到SME再到大型最终用户）的不同阶段，潜水员，互补的工业利益相关者在财团（从制药到材料科学到可持续性）中的存在为广泛的价值创造提供了独特的机会。计划的活动将跨越48个月，该项目估计为CA。 9 m€，总数的60％致力于创造高素质的工作