A Role for the Astrocytic Network in Spatial Navigation

星形胶质细胞网络在空间导航中的作用

• 批准号: 10360100
• 负责人: Mona Buhusi
• 金额: $ 43.8万
• 依托单位: UTAH STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-02-15 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10360100
• 关键词: Address; Affect; Aging; Anatomy; Animal Model; Animals; Astrocytes; Behavior; Behavioral; Biochemistry; Biological Assay; Biological Process; Blood - brain barrier anatomy; Brain; Cells; Chemical Synapse; Clinical Treatment; Cognitive; Communication; Complex; Connexin 43; Connexins; Coupling; Cues; Degenerative Disorder; Dyes; Elderly; Electron Microscopy; Environment; Episodic memory; Female; Food; Future; GJB6 gene; Gap Junctions; Goals; Hippocampus (Brain); Immunohistochemistry; Impairment; Individual; Infusion procedures; Lead; Learning; Location; Maintenance; Maps; Motion; Mus; Nerve Degeneration; Neuroglia; Neurons; Pattern; Pharmacology; Play; Process; Regulation; Reproduction; Role; Self Perception; Structure; Synapses; Time; Update; Viral Vector; age related; aged; aging hippocampus; base; cognitive function; cognitive process; dentate gyrus; experience; flexibility; improved; intercellular communication; male; neurobiological mechanism; neuronal circuitry; overexpression; prevent; spatial memory; stem; theories; way finding

Spatial navigation affords an adaptive advantage for all animal species, optimizing chances of survival and reproduction. This behavior involves a multitude of brain structures and cognitive functions, starting from perception of self-motion and environmental cues, to building spatial representations and goal integration. The hippocampus formation is particularly important for the building, maintaining, and updating spatial maps for navigation and planning. This project will explore the role of hippocampal astrocytic networks in spatial navigation and aging-related spatial navigation deficits. We will develop pharmacological manipulations to rescue behavioral deficits in aged mice. The project will enhance our understanding of the role of the hippocampal anatomy and connectivity in spatial navigation, the biological processes underlying behavioral deficits in aged individuals, and will help develop new remedial strategies in animal models, with possible subsequent impact on clinical treatments.

空间导航为所有动物物种提供了适应性优势，优化了 生存和繁殖。这种行为涉及大量的大脑结构和认知 功能，从自我运动和环境线索的感知开始， 表达和目标整合。海马体的形成对于 建立、维护和更新用于导航和规划的空间地图。这个项目 将探讨海马星形胶质细胞网络在空间导航和衰老相关的作用 空间导航缺陷我们将开发药物操作来拯救行为 老年小鼠的缺陷。该项目将增强我们对海马体作用的理解 空间导航中的解剖学和连通性，行为背后的生物过程， 缺陷，并将有助于在动物模型中开发新的补救策略， 可能对临床治疗产生后续影响。