Historical trauma and resilience as a biological state and its association with the effects of the traditional Indigenous food chokeberry

项目摘要 在美国印第安人中，实现健康公平和消除差距的速度尤其缓慢 尽管减少健康差距仍然是公共卫生机构的一个主要目标，但人口的健康状况仍然不容乐观。 美洲印第安人继续不成比例地遭受健康问题，包括 与营养有关的慢性疾病，如糖尿病和心脏病。因此，该研究项目将 调查一种名为chokeberry（黑果腺肋花楸）的传统土着食物如何影响表观遗传， 代谢健康与50名大平原印第安人参与者的弹性标志物有关。Chokeberry是 土著传统食物和药物，单独使用或与pemmican（布法罗、脂肪和 和chokeberry）在西方接触之前在美国和加拿大的某些地区很常见。由于 除了炎症标志物外，Chokeberry对人体脂质和葡萄糖指标的积极影响 在非土著环境中的先前研究中证明，值得在这一人群中进一步探索 基因和代谢谱都很不一样此外，与美国印第安人的研究过程 社区的重要性在于，它可以为社区参与方向的最佳做法提供信息， 方法和模型在未来的研究设置。 我们的具体目标是探索基因表达的变化，是由消费传统的 大平原印第安人的土著chokeberry，并检查代谢终点之间的关联， 表观遗传学，不良的童年经历，以及有和没有消费的心理健康 在大平原印第安人中发现的一种浆果。我们的长期目标是增加关系的知识基础 美国印第安人的传统食物消费，基因表达变化和代谢标志物之间的关系， 与创伤和恢复力的关系。 我们的研究是横向和纵向研究设计的混合。基线表观遗传、代谢和 将从研究参与者中收集心理健康数据进行横断面分析， 在餐后食用chokeberry汁后专门重复进行筛选，以评估其对 基线。表观遗传、代谢和心理健康数据收集过程将在6天后重复进行。 将收集变量与前一时间进行比较 收藏.

Project Abstract Achieving health equity and eliminating disparities has been especially slow in American Indian populations even though reducing health disparities continues to be a major goal of public health institutions. American Indian populations continue to suffer disproportionately from health problems including such nutrition-related chronic diseases as diabetes and heart disease. This research project will therefore investigate how a traditional Indigenous food called chokeberry (Aronia melanocarpa) impacts epigenetic and metabolic health in relation to resiliency markers in fifty Great Plains Indian participants. Chokeberry is an Indigenous traditional food and medicine used on its own or in mixtures of pemmican (a mixture of buffalo, fat and chokeberry) common before Western contact in certain areas of the United States and Canada. Due to chokeberry’s positive effects on human lipid and glucose measures, in addition to inflammation markers demonstrated in prior studies in non-Indigenous settings, it is worthy of further exploration in this population with very different gene and metabolic profiles. Also, the process of research with American Indian communities is significant in that it can inform best practices in community engagement orientations, approaches, and models in future research settings. Our specific aims are to explore gene expression changes that are mediated by the consumption of traditional Indigenous chokeberry in Great Plains Indians and to examine the associations between metabolic end points, epigenetics, adverse childhood experiences, and mental health with and without the consumption of chokeberry in Great Plains Indians. Our long-term aim is to increase the knowledge base on the relationships between American Indian traditional food consumption, gene expression changes and metabolic markers in relation to trauma and resilience. Our study is a mix of a cross-sectional and longitudinal study design. Baseline epigenetic, metabolic and mental health data will be collected from study participants for cross sectional analysis, with the epigenetic screen specifically repeated after the post prandial consumption of chokeberry juice to assess its effects from baseline. The epigenetic, metabolic and mental health data collection process will then be repeated after 6 weeks of the daily consumption of chokeberry juice to compare the collection variables to the previous time collections.