The Luma West Cardiac Detector - A First of Class Device to Diagnose/Exclude Cardiac Arrest with 95% Accuracy & within 5 Seconds, Saving up to 14,700 UK Lives Annually and 1.75m Worldwide.
%20Luma%20West%20Cardiac%20Detector%20-%20A%20First%20of%20Class%20Device%20to%20Diagnose/Exclusion%20Cardiac%20Arrest%20with%2095%%20Accuracy%20
基本信息
- 批准号:10056124
- 负责人:
- 金额:$ 63.7万
- 依托单位:
- 依托单位国家:英国
- 项目类别:Collaborative R&D
- 财政年份:2023
- 资助国家:英国
- 起止时间:2023 至 无数据
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
Luma West (Luma) is an innovative UK medtech company started by two brothers with medical and engineering expertise. Luma is solving an unaddressed global public health need that could save 1.75m million lives annually (Brouwer, 2015; see appendix 4): a method of rapidly and reliably diagnosing/excluding cardiac arrest.Cardiac arrest is a medical event in which a person's heart stops beating. There are 30,000 out-of-hospital cardiac arrests annually in the UK; only 8% are survived.Chest compressions -- where someone pushes up and down on the chest to pump blood around the body -- are the most important component of advanced life support.Although chest compressions can be life-saving, if the heart suddenly restarts, they break ribs and can cause outflow obstruction. Additionally, inaccurate diagnoses cause delays in appropriate treatment. Accurate, real-time and rapid diagnosis of cardiac arrest is critical according to the 2022 UK Resus Council guidelines.Unfortunately, the only recommended method of diagnosing cardiac arrest is by feeling for a central pulse during short assessments every two minutes (Resus Council, 2022). This is true even in the most state-of-the-art intensive care unit. Peripheral pulses and probes cannot be used as circulation to these areas shut down immediately before/after an arrest. Defibrillators/ECGs also cannot be used as they only measure heart rhythm, not output/function, and heart traces are normal in PEA - the most common out-of-hospital-arrestManual pulse check is incredibly unreliable (Eberle, 1996; Tibballs, 2019). When a pulse is present, 45% of the time it is missed: rib-breaking compressions are continued unnecessarily.When a pulse is absent, 10% of the time one is felt: compressions could be stopped despite being the only thing keeping the patient alive. Pulse check, even by doctors, takes 20--30 seconds (Brouwer, 2015), and survival decreases by 17% for every five-second interruption to compressions.Luma proposes a step-change in the diagnosis of cardiac arrest. This investment will be used to complete proof-of-concept work and prototyping, conduct a clinical trial and commence regulatory approval of a non-invasive diagnostic device suitable for use by non-medics that can, with 95% accuracy, diagnose/exclude cardiac arrest within five seconds. Luma's proposed package of device and training, if widely and publicly disseminated, could save 14,700 lives annually in the UK and 1.75m lives globally, increasing out-of-hospital cardiac arrest survival from 8% to 28% - physiologically possible as Norway has 25% survival of out-of-hospital-arrest.
Luma West(Luma)是一家创新的英国医疗科技公司,由两兄弟创办,拥有医疗和工程专业知识。Luma正在解决一个未得到解决的全球公共卫生需求,每年可以拯救175万人的生命(布劳沃,2015;见附录4):一种快速可靠地诊断/排除心脏骤停的方法。心脏骤停是一种医疗事件,在这种情况下,人的心脏停止跳动。在英国,每年有3万例院外心脏骤停;只有8%幸存下来。胸部按压--即人在胸部上下推动,在身体周围输送血液--是高级生命支持最重要的组成部分。尽管胸部按压可以挽救生命,但如果心脏突然重新启动,它们会折断肋骨,导致流出障碍。此外,不准确的诊断会导致适当治疗的延误。根据2022年英国心脏骤停理事会指南,准确、实时和快速地诊断心脏骤停是至关重要的。不幸的是,唯一推荐的诊断心脏骤停的方法是在每两分钟的短评估中触摸中心脉搏(Resus Council,2022)。即使在最先进的重症监护病房中也是如此。外周脉冲和探头不能用作对这些区域的循环,这些区域在逮捕之前/之后立即关闭。除颤器/心电图也不能使用,因为它们只测量心率,而不是输出/功能,而且心迹在PEA中是正常的-最常见的院外-逮捕-手动脉搏检查是令人难以置信的不可靠(Eberle,1996;Tibball,2019)。当脉搏存在时,45%的时间被错过:肋骨断裂按压不必要地继续。当脉搏消失时,有10%的时间可以感觉到:尽管按压是唯一能让患者存活的东西,但仍然可以停止按压。脉搏检查,即使是医生检查,也需要20-30秒(布劳沃,2015),按压每中断5秒,存活率就会下降17%。Luma提出了心脏骤停诊断的阶梯变化。这笔投资将用于完成概念验证工作和原型制作,进行临床试验,并开始监管部门批准一种适合非医务人员使用的非侵入性诊断设备,该设备可以在5秒内诊断/排除心脏骤停,准确率为95%。卢马提出的设备和训练方案,如果广泛和公开传播,可以拯救英国每年14,700人的生命和全球175万人的生命,将院外心脏骤停存活率从8%提高到28%--从生理上讲,挪威的院外心脏骤停存活率为25%。
项目成果
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其他文献
吉治仁志 他: "トランスジェニックマウスによるTIMP-1の線維化促進機序"最新医学. 55. 1781-1787 (2000)
Hitoshi Yoshiji 等:“转基因小鼠中 TIMP-1 的促纤维化机制”现代医学 55. 1781-1787 (2000)。
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LiDAR Implementations for Autonomous Vehicle Applications
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2021 - 期刊:
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吉治仁志 他: "イラスト医学&サイエンスシリーズ血管の分子医学"羊土社(渋谷正史編). 125 (2000)
Hitoshi Yoshiji 等人:“血管医学与科学系列分子医学图解”Yodosha(涉谷正志编辑)125(2000)。
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Effect of manidipine hydrochloride,a calcium antagonist,on isoproterenol-induced left ventricular hypertrophy: "Yoshiyama,M.,Takeuchi,K.,Kim,S.,Hanatani,A.,Omura,T.,Toda,I.,Akioka,K.,Teragaki,M.,Iwao,H.and Yoshikawa,J." Jpn Circ J. 62(1). 47-52 (1998)
钙拮抗剂盐酸马尼地平对异丙肾上腺素引起的左心室肥厚的影响:“Yoshiyama,M.,Takeuchi,K.,Kim,S.,Hanatani,A.,Omura,T.,Toda,I.,Akioka,
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