The Luma West Cardiac Detector - A First of Class Device to Diagnose/Exclude Cardiac Arrest with 95% Accuracy & within 5 Seconds, Saving up to 14,700 UK Lives Annually and 1.75m Worldwide.

%20Luma%20West%20Cardiac%20Detector%20-%20A%20First%20of%20Class%20Device%20to%20Diagnose/Exclusion%20Cardiac%20Arrest%20with%2095%%20Accuracy%20

• 批准号: 10056124
• 金额: $ 63.7万
• 依托单位: LUMA WEST LTD
• 依托单位国家: 英国
• 项目类别: Collaborative R&D
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=10056124
• 关键词: Luma; West; Cardiac; Detector; First

Luma West (Luma) is an innovative UK medtech company started by two brothers with medical and engineering expertise. Luma is solving an unaddressed global public health need that could save 1.75m million lives annually (Brouwer, 2015; see appendix 4): a method of rapidly and reliably diagnosing/excluding cardiac arrest.Cardiac arrest is a medical event in which a person's heart stops beating. There are 30,000 out-of-hospital cardiac arrests annually in the UK; only 8% are survived.Chest compressions -- where someone pushes up and down on the chest to pump blood around the body -- are the most important component of advanced life support.Although chest compressions can be life-saving, if the heart suddenly restarts, they break ribs and can cause outflow obstruction. Additionally, inaccurate diagnoses cause delays in appropriate treatment. Accurate, real-time and rapid diagnosis of cardiac arrest is critical according to the 2022 UK Resus Council guidelines.Unfortunately, the only recommended method of diagnosing cardiac arrest is by feeling for a central pulse during short assessments every two minutes (Resus Council, 2022). This is true even in the most state-of-the-art intensive care unit. Peripheral pulses and probes cannot be used as circulation to these areas shut down immediately before/after an arrest. Defibrillators/ECGs also cannot be used as they only measure heart rhythm, not output/function, and heart traces are normal in PEA - the most common out-of-hospital-arrestManual pulse check is incredibly unreliable (Eberle, 1996; Tibballs, 2019). When a pulse is present, 45% of the time it is missed: rib-breaking compressions are continued unnecessarily.When a pulse is absent, 10% of the time one is felt: compressions could be stopped despite being the only thing keeping the patient alive. Pulse check, even by doctors, takes 20--30 seconds (Brouwer, 2015), and survival decreases by 17% for every five-second interruption to compressions.Luma proposes a step-change in the diagnosis of cardiac arrest. This investment will be used to complete proof-of-concept work and prototyping, conduct a clinical trial and commence regulatory approval of a non-invasive diagnostic device suitable for use by non-medics that can, with 95% accuracy, diagnose/exclude cardiac arrest within five seconds. Luma's proposed package of device and training, if widely and publicly disseminated, could save 14,700 lives annually in the UK and 1.75m lives globally, increasing out-of-hospital cardiac arrest survival from 8% to 28% - physiologically possible as Norway has 25% survival of out-of-hospital-arrest.

Luma West (Luma) 是一家创新型英国医疗技术公司，由拥有医疗和工程专业知识的两兄弟创办。 Luma 正在解决一项尚未解决的全球公共卫生需求，每年可以挽救 175 万人的生命（Brouwer，2015 年；参见附录 4）：一种快速可靠地诊断/排除心脏骤停的方法。心脏骤停是一种人的心脏停止跳动的医疗事件。英国每年有 30,000 例院外心脏骤停；只有 8% 的人存活下来。胸外按压（即上下推动胸部以将血液泵送到全身）是高级生命支持最重要的组成部分。虽然胸外按压可以挽救生命，但如果心脏突然重新启动，则会折断肋骨并可能导致流出道阻塞。此外，不准确的诊断会导致适当治疗的延误。根据 2022 年英国复苏委员会指南，准确、实时和快速的心脏骤停诊断至关重要。不幸的是，诊断心脏骤停的唯一推荐方法是在每两分钟的短暂评估中感觉中央脉搏（复苏委员会，2022 年）。即使在最先进的重症监护室也是如此。外围脉冲和探头不能用作这些区域的循环在逮捕之前/之后立即关闭的情况。除颤器/心电图也不能使用，因为它们仅测量心律，而不测量输出/功能，并且 PEA 中的心脏痕迹是正常的 - 最常见的院外逮捕手动脉搏检查非常不可靠（Eberle，1996 年；Tibballs，2019 年）。当存在脉搏时，45% 的时间会被错过：不必要地继续进行导致肋骨断裂的按压。当脉搏不存在时，10% 的时间会感觉到按压：按压可以停止，尽管这是维持患者生命的唯一方法。即使由医生进行脉搏检查也需要 20--30 秒（Brouwer，2015），每中断按压 5 秒，存活率就会降低 17%。Luma 提出了心脏骤停诊断的重大变革。这项投资将用于完成概念验证工作和原型设计、进行临床试验并开始监管批准适合非医务人员使用的非侵入性诊断设备，该设备可以在 5 秒内诊断/排除心脏骤停，准确率高达 95%。 Luma 提出的设备和培训方案如果得到广泛和公开传播，每年可以挽救英国 14,700 条生命，全球挽救 175 万人的生命，将院外心脏骤停的存活率从 8% 提高到 28%——这在生理上是可能的，因为挪威的院外心脏骤停存活率为 25%。