The Luma West Cardiac Detector - A First of Class Device to Diagnose/Exclude Cardiac Arrest with 95% Accuracy & within 5 Seconds, Saving up to 14,700 UK Lives Annually and 1.75m Worldwide.

%20Luma%20West%20Cardiac%20Detector%20-%20A%20First%20of%20Class%20Device%20to%20Diagnose/Exclusion%20Cardiac%20Arrest%20with%2095%%20Accuracy%20

• 批准号: 10056124
• 金额: $ 63.7万
• 依托单位: LUMA WEST LTD
• 依托单位国家: 英国
• 项目类别: Collaborative R&D
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=10056124
• 关键词: Luma; West; Cardiac; Detector; First

Luma West (Luma) is an innovative UK medtech company started by two brothers with medical and engineering expertise. Luma is solving an unaddressed global public health need that could save 1.75m million lives annually (Brouwer, 2015; see appendix 4): a method of rapidly and reliably diagnosing/excluding cardiac arrest.Cardiac arrest is a medical event in which a person's heart stops beating. There are 30,000 out-of-hospital cardiac arrests annually in the UK; only 8% are survived.Chest compressions -- where someone pushes up and down on the chest to pump blood around the body -- are the most important component of advanced life support.Although chest compressions can be life-saving, if the heart suddenly restarts, they break ribs and can cause outflow obstruction. Additionally, inaccurate diagnoses cause delays in appropriate treatment. Accurate, real-time and rapid diagnosis of cardiac arrest is critical according to the 2022 UK Resus Council guidelines.Unfortunately, the only recommended method of diagnosing cardiac arrest is by feeling for a central pulse during short assessments every two minutes (Resus Council, 2022). This is true even in the most state-of-the-art intensive care unit. Peripheral pulses and probes cannot be used as circulation to these areas shut down immediately before/after an arrest. Defibrillators/ECGs also cannot be used as they only measure heart rhythm, not output/function, and heart traces are normal in PEA - the most common out-of-hospital-arrestManual pulse check is incredibly unreliable (Eberle, 1996; Tibballs, 2019). When a pulse is present, 45% of the time it is missed: rib-breaking compressions are continued unnecessarily.When a pulse is absent, 10% of the time one is felt: compressions could be stopped despite being the only thing keeping the patient alive. Pulse check, even by doctors, takes 20--30 seconds (Brouwer, 2015), and survival decreases by 17% for every five-second interruption to compressions.Luma proposes a step-change in the diagnosis of cardiac arrest. This investment will be used to complete proof-of-concept work and prototyping, conduct a clinical trial and commence regulatory approval of a non-invasive diagnostic device suitable for use by non-medics that can, with 95% accuracy, diagnose/exclude cardiac arrest within five seconds. Luma's proposed package of device and training, if widely and publicly disseminated, could save 14,700 lives annually in the UK and 1.75m lives globally, increasing out-of-hospital cardiac arrest survival from 8% to 28% - physiologically possible as Norway has 25% survival of out-of-hospital-arrest.

Luma West（Luma）是一家创新的英国医疗技术公司，由两兄弟创办，拥有医疗和工程专业知识。Luma正在解决一个尚未解决的全球公共卫生需求，每年可以挽救175万人的生命（Brouwer，2015;见附录4）：一种快速可靠地诊断/排除心脏骤停的方法。心脏骤停是一种医疗事件，其中一个人的心脏停止跳动。在英国，每年有3万例院外心脏骤停，只有8%的人存活下来。胸外按压--一个人上下按压胸部将血液泵到全身--是高级生命支持的最重要组成部分。尽管胸外按压可以挽救生命，但如果心脏突然重新跳动，它们会折断肋骨，并可能导致流出道阻塞。此外，不准确的诊断会导致适当治疗的延误。根据2022年英国Resus理事会指南，准确、实时和快速诊断心脏骤停至关重要。不幸的是，唯一推荐的诊断心脏骤停的方法是每两分钟进行一次短暂评估时感觉中心脉搏（Resus理事会，2022）。即使在最先进的重症监护室也是如此。外周脉冲和探头不能用作这些区域的循环，在停搏之前/之后立即关闭。也不能使用除颤器/ECG，因为它们仅测量心律，而不是输出/功能，并且PEA中的心脏描记正常-最常见的院外骤停手动脉搏检查非常不可靠（Eberle，1996; Tibballs，2019）。当有脉搏时，45%的时间会被忽略：肋骨断裂的按压是不必要的;当没有脉搏时，10%的时间会被感觉到：按压可能会停止，尽管这是唯一能让病人活着的方法。脉搏检查，即使是医生，也需要20- 30秒（Brouwer，2015），每5秒的按压中断，存活率就会下降17%。Luma提出了心脏骤停诊断的一个步骤。这笔投资将用于完成概念验证工作和原型设计，进行临床试验，并开始监管批准一种适合非医务人员使用的非侵入性诊断设备，该设备可以在5秒内以95%的准确率诊断/排除心脏骤停。Luma提出的设备和培训方案，如果广泛和公开传播，每年可以在英国挽救14，700人的生命，在全球挽救175万人的生命，将院外心脏骤停存活率从8%提高到28% -生理上可能，因为挪威的院外心脏骤停存活率为25%。