Physiology and Technology Core

生理与技术核心

• 批准号: 10364615
• 负责人: Zhi-Zhou He
• 金额: $ 25.73万
• 依托单位: CREIGHTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-03-05 至 2026-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10364615
• 关键词: Animal Model; Auditory; Auditory Brainstem Responses; Auditory Evoked Potentials; Auditory area; Biochemistry; Biological Models; Biomedical Research; Centers of Research Excellence; Clinical Investigator; Communication; Communities; Complex; Consultations; Core Facility; Development; Doctor of Medicine; Doctor of Philosophy; Electrophysiology (science); Elements; Environment; Equipment; Experimental Models; Faculty; Family; Fee-for-Service Plans; Foundations; Funding; Gene Mutation; Goals; Hearing; Human; Image; Individual; Infrastructure; Interdisciplinary Study; Laboratory Research; Larva; Mass Spectrum Analysis; Measures; Mentors; Methodology; Midwestern United States; Molecular Biology; Neurosciences; Phenotype; Physics; Physiology; Play; Principal Investigator; Productivity; Protocols documentation; Research; Research Personnel; Research Project Grants; Research Support; Resources; Role; Science; Scientist; Services; Structure; Techniques; Technology; Universities; Whole Organism; Zebrafish; design; educational atmosphere; hearing impairment; instrument; instrumentation; mass spectrometric imaging; medical schools; mid-career faculty; mouse model; multidisciplinary; otoacoustic emission; outreach program; professor; response; scientific atmosphere; single molecule; software development

PROJECT SUMMARY/ABSTRACT Auditory Vestibular Technology Core Core facilities are centralized shared research resources that provide access to instruments, technologies, as well as expert consultation and other services to scientific and clinical investigators. Core facilities are crucial for competitive multidisciplinary science and have become an integral part of biomedical research. The Auditory- Vestibular Technology (AVT) Core will be established to provide infrastructure to support Research Project Leaders and principal investigators associated with the Translational Hearing Center at Creighton University to conduct multidisciplinary auditory and vestibular research. We will achieve this goal by: 1) Providing state-of- the-art methodologies and instrumentation to faculty conducting auditory and vestibular studies in animal models. The AVT Core will provide state-of-the-art technical and scientific support for COBRE-supported translational auditory and vestibular researchers in the area of auditory and vestibular electrophysiology, molecular biology, imaging and mass spectrometry. The AVT Core will also provide the infrastructure necessary to capitalize on emerging technological developments. 2) Mentoring Core users in multidisciplinary research to successfully compete for research funding. To promote an interdisciplinary scientific environment within the Core itself, and among investigators in the region generally, the Core is dedicated to an intensive outreach program designed to encourage inter-investigator communication and introduce junior investigators to interdisciplinary methodologies available in the AVT Core. 3) Developing a sustainability plan to provide Core services for new and established investigators beyond COBRE funding. To meet this goal, an active outreach program will be implemented and a fee-for-service structure will be developed. The AVT Core will play an essential role to the establishment of multidisciplinary Translational Hearing Center by providing services to research projects that validate ototherapeutics. The core will also augment the intellectual and scientific atmosphere of the local and Midwest auditory research community, now and beyond COBRE support.

项目摘要/摘要 听觉前庭技术核心 核心设施是集中共享的研究资源，提供访问仪器、技术、 以及为科学和临床研究人员提供专家咨询和其他服务。核心设施至关重要 为竞争激烈的多学科科学提供支持，并已成为生物医学研究的组成部分。听觉上的- 将建立前庭技术(AVT)核心，为支持研究项目提供基础设施 与克雷顿大学翻译听证中心有关的领导和主要调查人员 进行多学科的听觉和前庭研究。我们将通过以下方式实现这一目标：1)提供 在动物模型中进行听觉和前庭研究的最先进的方法和仪器。 AVT Core将为Cobre支持的翻译提供最先进的技术和科学支持 听觉和前庭研究人员在听觉和前庭电生理、分子生物学、 成像和质谱学。AVT核心还将提供必要的基础设施，以利用 新兴的技术发展。2)指导多学科研究的核心用户，以成功 争夺研究经费。促进核心内部的跨学科科学环境，以及 在该区域的一般调查人员中，核心致力于一项密集的外联方案，旨在 鼓励调查员之间的交流，向初级调查员介绍跨学科的方法 在AVT核心中可用。3)制定可持续发展计划，为新老企业提供核心服务 科布雷基金之外的调查人员。为实现这一目标，将实施一项积极的外展方案， 发展按服务收费结构。AVT核心将对建立 多学科翻译听证中心为研究项目提供服务，验证 耳治疗学。核心还将增强当地和中西部的知识和科学氛围 听觉研究社区，现在和超越科布雷的支持。