Physiology and Technology Core

生理与技术核心

• 批准号: 10579964
• 负责人: Zhi-Zhou He
• 金额: $ 11.03万
• 依托单位: CREIGHTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-03-05 至 2026-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10579964
• 关键词: Animal Model; Auditory; Auditory Brainstem Responses; Auditory Evoked Potentials; Auditory area; Biochemistry; Biological Models; Biomedical Research; Centers of Research Excellence; Clinical Investigator; Communication; Communities; Complex; Consultations; Core Facility; Dedications; Development; Doctor of Medicine; Doctor of Philosophy; Electrophysiology (science); Elements; Emerging Technologies; Environment; Equipment; Experimental Models; Faculty; Family; Fee-for-Service Plans; Foundations; Funding; Gene Mutation; Goals; Hearing; Human; Image; Individual; Infrastructure; Interdisciplinary Study; Laboratory Research; Larva; Mass Spectrum Analysis; Measures; Mentors; Methodology; Midwestern United States; Molecular Biology; Neurosciences; Phenotype; Physics; Physiology; Play; Principal Investigator; Productivity; Protocols documentation; Research; Research Personnel; Research Project Grants; Research Support; Resources; Role; Science; Scientist; Services; Structure; Techniques; Technology; Universities; Whole Organism; Zebrafish; brain stem auditory evoked potentials; design; educational atmosphere; hearing impairment; instrument; instrumentation; medical schools; mid-career faculty; model organism; mouse model; multidisciplinary; otoacoustic emission; outreach program; professor; response; scientific atmosphere; single molecule; software development; technology development

PROJECT SUMMARY/ABSTRACT Auditory Vestibular Technology Core Core facilities are centralized shared research resources that provide access to instruments, technologies, as well as expert consultation and other services to scientific and clinical investigators. Core facilities are crucial for competitive multidisciplinary science and have become an integral part of biomedical research. The Auditory- Vestibular Technology (AVT) Core will be established to provide infrastructure to support Research Project Leaders and principal investigators associated with the Translational Hearing Center at Creighton University to conduct multidisciplinary auditory and vestibular research. We will achieve this goal by: 1) Providing state-of- the-art methodologies and instrumentation to faculty conducting auditory and vestibular studies in animal models. The AVT Core will provide state-of-the-art technical and scientific support for COBRE-supported translational auditory and vestibular researchers in the area of auditory and vestibular electrophysiology, molecular biology, imaging and mass spectrometry. The AVT Core will also provide the infrastructure necessary to capitalize on emerging technological developments. 2) Mentoring Core users in multidisciplinary research to successfully compete for research funding. To promote an interdisciplinary scientific environment within the Core itself, and among investigators in the region generally, the Core is dedicated to an intensive outreach program designed to encourage inter-investigator communication and introduce junior investigators to interdisciplinary methodologies available in the AVT Core. 3) Developing a sustainability plan to provide Core services for new and established investigators beyond COBRE funding. To meet this goal, an active outreach program will be implemented and a fee-for-service structure will be developed. The AVT Core will play an essential role to the establishment of multidisciplinary Translational Hearing Center by providing services to research projects that validate ototherapeutics. The core will also augment the intellectual and scientific atmosphere of the local and Midwest auditory research community, now and beyond COBRE support.

项目总结/摘要 听觉前庭技术核心 核心设施是集中共享的研究资源，提供使用仪器，技术， 以及为科学和临床研究人员提供专家咨询和其他服务。核心设施至关重要 竞争性的多学科科学，并已成为生物医学研究的一个组成部分。听觉- 将建立前庭技术（AVT）核心，为支持研究项目提供基础设施 领导人和主要研究人员与克雷顿大学翻译听力中心， 进行多学科的听觉和前庭研究。我们将通过以下方式实现这一目标：1）提供国家- 最先进的方法和仪器，以教师进行听觉和前庭研究的动物模型。 AVT核心将为COBRE-Support翻译提供最先进的技术和科学支持。 听觉和前庭电生理学，分子生物学， 成像和质谱分析。AVT核心还将提供必要的基础设施， 新兴技术发展。2)指导多学科研究中的核心用户， 争取研究经费。在核心内部促进跨学科的科学环境， 在该地区的调查人员中，核心小组致力于一项密集的外联计划， 鼓励研究者之间的交流，并向初级研究者介绍跨学科方法 在AVT Core中可用。3)制定可持续发展计划，为新老客户提供核心服务 除了COBRE的资金之外为了实现这一目标，将实施一项积极的外联方案， 将建立收费服务结构。AVT核心将在建立 多学科翻译听力中心通过提供服务的研究项目，验证 耳治疗学该中心还将增强当地和中西部的知识和科学氛围 听觉研究社区，现在和超越COBRE的支持。